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Inhibition of mammalian topoisomerase I by 1-nitro-9-aminoacridines. Dependence on thiol activation

100%

Ciesielska E., Pastwa E., Szmigiero L.

Acta Biochimica Polonica

1997

tom 44

nr 4

The cytotoxic activity, susceptibility to thiol activation and ability of eight 1-nitroacridine derivatives to stabilize the topoisomerase I-DNA cleavable complex, were compared. Among the acridines tested three compounds exhibited high ability to stabilize the cleavable complex. This ability was correlated with susceptibility to thiol activation as well as with cytotoxic activity. Our results suggest that 1-nitroacridine-DNA adducts interfering with topoisomerase I action may contribute to the lethal effects of some 1-nitroacridine derivatives.

Thiol dependent inhibition of mouse leukemia L1210 DNA topoisomerase I by nitracrine

84%

Ciesielska E., Szmigiero L.

Acta Biochimica Polonica

1994

tom 41

nr 2

DNA-protection cross-linking induced by nitracrine in two strains of mouse lymphoma L5178Y cells

84%

Ciesielska E., Walicka M., Pastwa E., Szmigiero L.

Acta Biochimica Polonica

1992

tom 39

nr 1

DNA-protein crosslinks induced in HeLa cells by bis-1-nitroacridines

84%

Pastwa E., Ciesielska E., Studzian K., Szmigiero L.

Acta Biochimica Polonica

1993

tom 40

nr 1

Ograniczanie wyników

4 Acta Biochimica Polonica

4 Ciesielska E.

4 Szmigiero L.

3 Pastwa E.

1 Studzian K.

1 Walicka M.

1 1997

1 1994

1 1993

1 1992

Wyniki wyszukiwania

Inhibition of mammalian topoisomerase I by 1-nitro-9-aminoacridines. Dependence on thiol activation

Thiol dependent inhibition of mouse leukemia L1210 DNA topoisomerase I by nitracrine

DNA-protection cross-linking induced by nitracrine in two strains of mouse lymphoma L5178Y cells

DNA-protein crosslinks induced in HeLa cells by bis-1-nitroacridines