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The HLA class II region genes DQB1*0602 and DQA1*0102 are currently the best genetic predictors for narcolepsy in humans [1], The aim of this study was to identify the HLA DQ alleles (DQB1*0602 and DQA1*0102) in Slovene sporadic narcoleptic patients. 11 patients who fulfilled ICSD criteria for narcolepsy entered the study. DRB1*1501 DQB1*0602 was present in all the patients while DQA1*0102 was absent in 2 patients. We propose that DQB1*0602 typing is important in diagnosing narcolepsy in Slovene patients.
Background. The objective of the study was to explore the dynamics of the functional state of the central nervous system (CNS) and neurophysiological processes of girls 16-18 years old in the context of their transition to a new level of social organization. Material and methods. The functional state of the CNS was studied in girls 16-18 years old in a state of relative muscular rest through observation of visible motive reactions, Loskutova’s method, and in the fifth minute of renewal after the physical loading with variable power. Results. We found that 17 year-old girls had the best functional CNS capabilities. The reduced adaptive capacity of the CNS in 16 year-old girls is due to their necessity for adaptive reorganization of regulatory mechanisms to new social conditions: examinations and university entry. After physical activity, 16 and 18 year-old girls registered stress reactions, indicating decreased CNS adaptation. Conclusions. 17 year-old girls were observed at rest to have better CNS functionality compared to the other age groups. Analysis of the dynamics of the functional CNS states of 16–18 year-old girls after exercise resulted in the identification of two main reaction types: 1) reduction of the basic criteria at high initial values; 2) increase of criteria of a general functional state of a brain at low raw data.
Gromysz H., Karczewski W. A., Kukwa A., Jernajczyk U.: Breuer-Hering reflexes in ketamine-induced apneustic breathing in the rabbit. Acta Physiol. Pol. The effects of ketamine on the activities of the mylohyoid nerve (a branch of the Vth nerve) and of both phrenic nerves were investigated in rabbits anaesthetized with halothane, paralyzed and artificially ventilated. Intravenous administration of ketamine elicited a marked prolongation of the phrenic inspiratory discharge [without] not significantly affecting its amplitude) and a depression of the mylohyoid expiratory activity. An elimination of the volume-related input from the lungs (“no inflation manoeuvre” or deflation) elicited under these conditions typical apneustic pattern of breathing. The response to tracheal occlusion at peak-inspiration was “classical”. We conclude that ketamine inhibits the Vth nerve motor nucleus which is not only an important component of the central inspiratory-inhibitory neurones but also a “relay station” between the vagal and the central inspiratory “off-switch” mechanisms.
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History traces of gastrointestinal motility in Poland

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The objectives of this chapter was to show how motility studies were developed and performed in Poland at the end of century to better understand pathophysiology and improve the clinicians ability to evaluate and treat patients with motility - related disorders. Some of the important historical points along the path to current understanding of the form and function of gastrointestinal motility are presented. Scarce information exists about other than Cracow and Wroc³aw motility centers in Poland in previous century. Lately sophisticated technology became available in Poland and more centers have begun to yield more effective strategies of treatment and enhanced understanding of the pathophysiologic mechanisms underlying GI motility disorders.
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Adolf Beck 1863-1942

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Janina Hurynowicz 1894-1967

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