Ograniczanie wyników

Czasopisma help
Autorzy help
Lata help
Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 121

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 7 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  neurony
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 7 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
Apelin (APLN) is a new peptide which was initially gained from extracts of the bovine stomach mucous membrane. It has a few isoforms differing in length of polypeptide chain and biological activity. Apelin exerts a biological effect using a specific apelin receptor (APJ). At present, there is an increase of interest in this peptide and its receptor because they are specifically localized in the central nervous system (OUN). By means of immunohistochemical techniques it has been demonstrated that the majority of neurons contain APLN and some neurons along with oligodendrocytes and astrocytes accompanying them reveal a clear localization of the APJ receptor both in the white and grey matter of the spinal cord and brain. APLN can participate in the OUN’s development. It performs a function of neurotransmitter and neuromodulator as well as a regulator of synaptic conductivity. This peptide controls neuroendocrine mechanisms in the hypothalamus-pituitary axis. APLN regulates circadian rhythms as well as drinking and eating mechanisms in the pineal gland. In astrocytes APLN can exert neuroprotective activity and regulate astrocyte-neuron interactions. APLN’s influence on the functioning of glia and neurons through the APJ receptor has not been fully explained. Further examination can provide information about APLN’s role and its APJ receptor in normal and pathologically changed OUN.
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Engram

86%
The aim of the study was to determine the existence and co-existence patterns of VIP and NPY in neurons and nerve fibers of porcine lumbar-sacral sympathetic chain ganglia. The studied ganglia were fixed with 4% buffered paraformaldehyde (perfusion) and then labeled by means of double-immunofluorescence using a mixture of antibodies cultivated in different species. The highest number of NPY-positive cells was observed in the lumbar ganglia and diminished in the direction of the caudal, where only single neurons were observed. In contrast, a different pattern of distribution was observed for VIP-positive neurons, whose number was higher in the more caudally located ganglia. Two populations of VIP-positive neurons could be distinguished: single, showing strong immunofluorescence and often with visible processes, located in the central part of the ganglia and a second population, composed of clusters of 4-8 cells and often co-localizing NPY. VIP-positive nerve fibers surrounded both NPY+ neurons and neurons lacking either NPY and/or VIP. The presence of a small number of NPY-positive neurons exhibiting very weak immunofluorescence in more caudally located SChG could suggest a "switch" of neuromediators produced there. An increase in the percentage of non-noradrenergic sympathetic neurons in more caudally located SChG may thus be implicative for a specific innervation pattern of target tissues of these ganglia.
The main aim of the study was to investigate the intracellular localization of the following calcium-binding proteins: parvalbumin, calbindin and calretinin. 15 sexually mature chinchilla males (about 1.5 years old) were used in the examination. The hippocampus was collected from each immediately after the slaughter, fixed and properly prepared for immunohistochemical examinations. Peroxidase-anti-peroxidase (PAP) reaction was carried out using specific antibodies against parvalbumin and calbindin D28k, as well as calretinin. Our own examination results have shown cytoplasmic as well as nuclear reactions in the examined regions of the hippocampal areas (CA1-CA4) and dentate gyrus. Only in the CA2 area was no nuclear reaction observed for the examined proteins, as well as in the CA1 area for calretinin. Intracellular localization of calcium-binding proteins proves that regulatory functions of parvalbumin, calbindin and calretinin lead to neuronal plasticity, i.e. to a change of their activity. Therefore, calcium-binding proteins may be indirectly involved in the regulation of metabolic processes affecting basic vital functions of neurons.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 7 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.