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Melanophores inside frogs

100%

Pshennikova E. S., Voronina A. S.

International Letters of Natural Sciences

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2018

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tom 71

Melanocytes/melanophores were known for some decades as pigment cells in skin. The origin of these cells in embryogenesis from neural crest cells is actively investigated now. Some melanocytes/melanophores were described inside adult vertebrates. Historically, these internal melanocytes have been largely ignored, until recently. In frogs, the melanophores populate not only the skin, but all the inner connective tissues: epineurium, peritoneum, mesentery, outer vascular layer and skin underside. In adult avian, melanocytes were also found in visceral connective tissues, periostea, muscles, ovaries and the peritoneum. In mammals and humans, melanocytes are also revealed in eyes, ears, heart and brain. A black-brownish pigment, which can be found in brains of humans and some mammals, was called neuromelanin. Currently, attempts are being made to treat neurodegenerative diseases and various nerve injuries with medications containing melanin. In this micro-review, we wanted to remind again about the inner melanophores on visceral organs and lining blood vessels and nerves, their importance in organisms resistance to adverse environmental factors.

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Antioxidative activity of catecholamines and model neuromelanins as assayed by electrochemiluminescence

100%

Chmura J., Slawinski J.

Acta Biologica Cracoviensia. Series Zoologia

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2000

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tom 42

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The influence of microwave power on the two-component ESR spectra of noradrenaline-melanin

84%

Pilawa B., Stepien K., Wilczok T.

Current Topics in Biophysics

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1994

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tom 18

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nr 2

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Antioxidant activity of model neuromelanins in the process of lipid peroxidation

67%

Stepien K., Wilczok T.

Current Topics in Biophysics

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1994

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tom 18

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nr 2

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Controversies about iron in parkinsonian and control substantia nigra

67%

Galazka-Friedman J., Friedman A.

Acta Neurobiologiae Experimentalis

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1997

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tom 57

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nr 3

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Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins

67%

Stepien K., Wilczok A., Zajdel A., Dzierzega-Lecznar A., Wilczok T.

Acta Biochimica Polonica

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2000

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tom 47

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nr 4

Peroxynitrite-mediated linoleic acid oxidation and tyrosine nitration were analysed in the presence of synthetic model neuromelanins: dopamine (DA) -melanin, cysteinyldopamine (CysDA) -melanin and various DA/CysDA copolymers. The presence of melanin significantly decreased the amount of 3-nitrotyrosine formed. This inhibitory effect depended on the type and concentration of melanin polymer. It was found that incorporation of CysDA-derived units into melanin attenuated its protective effect on tyrosine nitration induced by peroxynitrite. In the presence of bicarbonate, the melanins also inhibited 3-nitrotyrosine formation in a concentration dependent manner, although the extent of inhibition was lower than in the absence of bicarbonate. The tested melanins inhibited peroxynitrite-induced formation of linoleic acid hydroperoxides, both in the absence and in the presence of bicarbonate. In the presence of bicarbonate, among the oxidation products appeared 4-hydroxynonenal (HNE). CysDA-melanin inhibited the formation of HNE, while DA-melanin did not affect the aldehyde level. The results of the presented study suggest that neuromelanin can act as a natural scavenger of peroxynitrite.

Ograniczanie wyników

2 Current Topics in Biophysics

1 Acta Biochimica Polonica

1 Acta Biologica Cracoviensia. Series Zoologia

1 Acta Neurobiologiae Experimentalis

1 International Letters of Natural Sciences

3 Stepien K.

3 Wilczok T.

1 Chmura J.

1 Dzierzega-Lecznar A.

1 Friedman A.

1 Galazka-Friedman J.

1 Pilawa B.

1 Pshennikova E. S.

1 Slawinski J.

1 Voronina A. S.

1 Wilczok A.

1 Zajdel A.

1 2018

2 2000