Wyniki wyszukiwania

1

Growth factor gene delivery for Alzheimer's disease: from animal models to clinical trials

100%

Tuszynski M., Nagahara A., Schroeder B., Coppola G., Wang L., Blesch A., Rockenstein E., Geschwind D., Masliah E., Koo E., Chiba A.

Acta Neurobiologiae Experimentalis

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2009

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tom 69

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nr 3

Nervous system growth factors have extensive effects on neuronal function and survival. Nerve growth factor (NGF) prevents the death and stimulates the function of basal forebrain cholinergic neurons in correlational models of Alzheimer’s disease (AD), leading to its translation to Phase 1 and 2 human clinical trials. Separately, Brain-Derived Neurotrophic Factor (BDNF) infl uences the survival and function of entorhinal cortical and hippocampal neurons in several animal models of AD, including transgenic mutant APP-expressing mice; aged rats and lesioned rats; and aged and lesioned primates. These benefi cial effects appear to occur independent of alteration in beta amyloid load. We are currently examining the extended safety and tolerability of BDNF gene delivery to the entorhinal cortex in additional animal studies, potentially leading to specifi c targeting of short term memory loss in future human AD trials. This talk will review the history and current status of growth factor gene delivery in AD and other neurodegenerative disorders.

2

Expression of nerve growth factor in rat stomach. Implications for interactions between endothelial, neural and epithelial cells

100%

Tarnawski A. S., Ahluwalia A., Jones M. K., Brzozowski T.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 6

3

Expression of leptin, NGF and adiponectin in metabolic syndrome

100%

Atanassova P., Hrischev P., Orbetzova M., Nikolov P., Nikolova J., Georgieva E.

Folia Biologica

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2014

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tom 62

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nr 4

4

Stem cell-based approaches to improve nerve regeneration: potential implications for reconstructive transplantation?

100%

Khalifian S., Sarhane K. A., Tammia M., Ibrahim Z., Mao H.-Q., Cooney D. S., Shores J. T., Lee W. P. A., Brandacher G.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

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nr 1

5

Nerve growth factor injected into the gastric ulcer base incorporates into endothelial, neuronal, glial and epithelial cells: implications for angiogenesis, mucosal regeneration and ulcer healing

100%

Tanigawa T., Ahluwalia A., Watanabe T., Arakawa T., Tarnawski A. S.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 4

6

Expression of nerve growth factor, its TRKA receptor, and several neuropeptides in porcine esophagus. Implications for interactions between neural, vascular and epithelial components of the esophagus

100%

Samarasena J. B., Ahluwalia A., Tarnawski A. S., Shinoura S., Choi K. D., Lee J. G., Chang K. J.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 3

7

Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo-hippocampal pathways

100%

Skup M., Bacia A., Koczyk D., Jeglinski W., Zaremba M., Oderfeld-Nowak B.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 2

8

Morphochemical investigations on postnatal development of the adrenal medulla in guinea pigs

100%

Kaczmarczyk D., Kmiec B. L.

Folia Histochemica et Cytobiologica. Supplement

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1996

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tom 34

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nr 1

9

TNF receptors - how they function and interact

100%

Bigda J., Holtmann H.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 4

10

Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men

80%

Zoladz J. A., Pilc A., Majerczak J., Grandys M., Zapart-Bukowska J., Duda K.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 7

11

Expression and localization of nerve growth factor (NGF) in the testis of alpaca (llama pacos)

80%

Wang H., Dong Y., Chen W., Hei J., Dong C.

Folia Histochemica et Cytobiologica

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2011

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tom 49

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nr 1

12

Local regulators of seasonal reproduction processes in uterus masculinus of an adult male European bison (Bison bonasus, Linnaeus 1758)

80%

Tabecka-Lonczynska A., Mytych J., Solek P., Abrachamowicz A., Welz M., Koziorowski M.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 5

13

Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein

80%

Bator J., Varga J., Berta G., Barbakadze T., Mikeladze D., Ramsden J., Szeberenyi J.

Cellular and Molecular Biology Letters

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2012

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tom 17

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nr 3

Nitric oxide (NO) is a mediator of a diverse array of inter- and intracellular signal transduction processes. The aim of the present study was to analyze its possible role as a second messenger in the process of neuronal differentiation of PC12 pheochromocytoma cells. Upon NGF treatment wildtype PC12 cells stop dividing and develop neurites. In contrast, a PC12 subclone (designated M-M17-26) expressing a dominant-negative mutant Ras protein keeps proliferating and fails to grow neurites after NGF treatment. Sodium nitroprusside (SNP), an NO donor, was found to induce the p53 protein and to inhibit proliferation of both PC12 and M-M17-26 cells, but failed to induce neuronal differentiation in these cell lines. Key signaling pathways (the ERK and Akt pathways) were also not affected by SNP treatment, and the phosphorylation of CREB transcription factor was only slightly stimulated. It is thus concluded from the results presented in this paper that NO is unable to activate signaling proteins acting downstream or independent of Ras that are required for neuronal differentiation.

14

BDNF and NT-3 widen the scope of neurotrophin activity: Pharmacological implications

80%

Skup M. H.

Acta Neurobiologiae Experimentalis

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1994

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tom 54

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nr 2

15

Nuclear accumulation of nerve growth factor and its receptor in meningioma and glioma tumour cells

80%

Jagodzinski P. P., Kaczmarski W., Zukiel R.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1992

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tom 40

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nr 2

16

Recent advances in neonatal pain research

80%

Kostarczyk E.

Folia Morphologica. Supplement

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1999

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tom 58

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nr 2

17

Evaluation of epidermal growth factor interaction with cell surface and its accumulation in nuclei of lung carcinoma, epidermiod carcinoma and melanoma cell lines

80%

Jagodzinski P. P., Kaczmarski W., Trzeciak W. H.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1992

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tom 40

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nr 4

18

Cellular localization of nerve growth factor - like immunoreactivity in hippocampus and septum of adult rat brain

80%

Bacia A., Aloe L., Fusco M., Vantini G., Leon A., Oderfeld-Nowak B.

Acta Neurobiologiae Experimentalis

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1992

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tom 52

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nr 1

19

Signalling pathways mediating anti-apoptotic action of neurotrophins

80%

Hetman M., Xia Z.

Acta Neurobiologiae Experimentalis

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2000

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tom 60

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nr 4

Neurotrophins promote survival and suppress apoptosis in many populations of neurons. Currently, phosphatidylinositol-3 kinase (PI-3K) is recognized as the main mediator of this protective effect. However, most of the data collected so far on the anti-apoptotic signaling of neurotrophins were obtained using trophic withdrawal paradigms. Recent data from our and other groups indicate that extracellular-signal-regulated kinase 1/2 (Erk1/2) may play a critical role in suppressing neuronal apoptosis triggered by cellular damage. Thus, it appears that either Erk1/2 or PI-3K, depending on the nature of the death-inducing stimulus, can mediate anti-apoptotic signaling of neurotrophins. In this review, we discuss the contribution of Erk1/2 and PI-3K to neuroprotection by neurotrophins. We also present data suggesting possible mechanisms by which these pathways might suppress neuronal death.

20

Trimethyltin - induced plastic neuronal changes in rat hippocampus are accompanied by astrocytic trophic activity

80%

Koczyk D., Skup M., Zaremba M., Oderfeld-Nowak B.

Acta Neurobiologiae Experimentalis

|

1996

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tom 56

|

nr 1

Ograniczanie wyników

Growth factor gene delivery for Alzheimer's disease: from animal models to clinical trials

Expression of nerve growth factor in rat stomach. Implications for interactions between endothelial, neural and epithelial cells

Expression of leptin, NGF and adiponectin in metabolic syndrome

Stem cell-based approaches to improve nerve regeneration: potential implications for reconstructive transplantation?

Nerve growth factor injected into the gastric ulcer base incorporates into endothelial, neuronal, glial and epithelial cells: implications for angiogenesis, mucosal regeneration and ulcer healing

Expression of nerve growth factor, its TRKA receptor, and several neuropeptides in porcine esophagus. Implications for interactions between neural, vascular and epithelial components of the esophagus

Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo-hippocampal pathways

Morphochemical investigations on postnatal development of the adrenal medulla in guinea pigs

TNF receptors - how they function and interact

Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men

Expression and localization of nerve growth factor (NGF) in the testis of alpaca (llama pacos)

Local regulators of seasonal reproduction processes in uterus masculinus of an adult male European bison (Bison bonasus, Linnaeus 1758)

Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein

BDNF and NT-3 widen the scope of neurotrophin activity: Pharmacological implications

Nuclear accumulation of nerve growth factor and its receptor in meningioma and glioma tumour cells

Recent advances in neonatal pain research

Evaluation of epidermal growth factor interaction with cell surface and its accumulation in nuclei of lung carcinoma, epidermiod carcinoma and melanoma cell lines

Cellular localization of nerve growth factor - like immunoreactivity in hippocampus and septum of adult rat brain

Signalling pathways mediating anti-apoptotic action of neurotrophins

Trimethyltin - induced plastic neuronal changes in rat hippocampus are accompanied by astrocytic trophic activity