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1

Neuroendocrine cells in the nasal mucosa - preliminary report

100%
Sieskiewicz A., Olszewska M., Olszewska E., Garbowicz M., Trojan S., Chyczewski L., Rogowski M.
Folia Histochemica et Cytobiologica
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2007
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tom 45
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nr 2
2
Content available remote

Convergence of nasal and tracheal neural pathways in modulating the cough response in guinea pigs

84%
Plevkova J., Antosiewicz J., Verechova S., Poliacek I., Jakus J., Tatar M., Pokorski M.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 2
89-93
In the present study we investigated the possibility of central convergence of neural pathways coming from distant anatomical regions in modulating the cough response. We addressed this issue by inducing cough from the tracheo-bronchial region on the background of capsaicin-stimulated and mesocain-blocked nasal mucosa in 14 anesthetized guinea pigs. The control group consisted of 6 guinea pigs in which the active agents, capsaicin and mesocain, were substituted for by inert physiological saline. All animals were tracheostomized, and the larynx was disconnected from the proximal part of the trachea with preserved innervations, and all were subjected to the same protocol. Cough, induced by mechanical irritation of the tracheo-bronchial mucosa, was elicited three times: in the control condition, after intranasal capsaicin challenge, and after another capsaicin challenge preceded by intranasal instillation of a local anesthetic, mesocain. The main finding of the study was that the number of cough efforts per bout, assessed from positive deflections on the intrapleural pressure recordings, was significantly enhanced by intranasal capsaicin challenge and this effect was reversed by intranasal pretreatment with the anesthetic mesocain [2.1 ±0.2 (control) vs. 3.5 ±0.4 (capsaicin) vs. 2.2 ±0.2 (capsaicin after mesocain) (P<0.01)], with no appreciable changes in the magnitude of cough efforts. The cough response in the control group remained unchanged. We conclude that tracheo-bronchial cough may be modified by neural sensory input to the brain coming from nasal mucosa. Therefore, cough reflex is subject to central convergence of peripheral neural pathways originating at distant anatomical locations.
3
Content available remote

In vivo and in vitro studies on multidirectional mechanism of anti-allergic activity of budesonide

84%
Trybus E., Krol G., Obarzanowski T., Trybus W., Kopacz-Bednarska A., Obarzanowski M., Krol T.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 6
4
Content available remote

Quercetin attenuates naso-sinusal inflammation and inflammatory response in lungs and brain on an experimental model of acute rhinosinusitis in rats

84%
Tiboc-Schnell C. N., Filip G. A., Man S. C., Decea N., Moldovan R., Opris R., Sas V., Tabaran F.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 4
5

Local transport of testosterone from the nasal mucosa to the carotid blood and the brain in the pig

84%
Skipor J., Grzegorzewski W., Krzymowski T., Einer-Jensen N.
Polish Journal of Veterinary Sciences
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2000
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tom 03
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nr 1
Local counter current transfer of substances between venous and arterial vessels has been found in the perihypophyseal vascular complex after administration into the supraorbital vein. The present experiments investigate whether similar transfer could be found after nasal administration of testosterone. Experiments were conducted on the model of isolated pig's head perfused with autologous blood through one carotid artery. Tritium labelled testosterone was infused onto the nasal mucous. Radioactivity was measured in blood samples collected from the contralateral carotid artery (indicator of transfer), in the venous effluent from the jugular veins (indicator of absorption), and in tissue samples from the olfactory bulb, olfactory triangle, hypothalamus, mammillary body, cortex, pons, cerebellum, neurohypophysis, adenohypophysis, pia vessels and perihypophyseal vascular complex. The absorption was 11.4 ±4.6 per cent (mean ± SEM) and 0.4 ±0.3 per cent of the instilled testosterone was transferred during the 25 min collection period. The uptake of radioactivity was seen in many of the brain tissue samples representing the brain, pituitary, pia vessels and cavernous sinus - carotid rete complex, although a clear pattern was not seen. Nasally administered drugs may thus reach the brain in a relatively higher concentration than it reaches the rest of the body. This makes targeted treatment of the brain a distinct possibility. Additionally, the treatment will decrease the first-passage metabolism in the liver.
6

Desloratadine ameliorates olfactory disorder and suppresses AMPA receptor GluA1 expression in allergic rhinitis rat

67%
Li S., Zhang X., Li Z., Jiang X., Zhang N., Zhang J., Huang Y., Zhao H., Jiang Y., Li N.
Archivum Immunologiae et Therapiae Experimentalis
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2020
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tom 68
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nr 1
7

The influence of steroids on the vascular tension of isolated superficial nasal and facial veins in gilts during sexual maturation

67%
Grzegorzewski W. J., Muszak J., Tabecka-Lonczynska A., Stefanczyk-Krzymowska S.
Polish Journal of Veterinary Sciences
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2010
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tom 13
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nr 2
8

The occurrence and comparative phenotypic characteristics of Staphylococcus spp. from healthy and diseased, household and shelter dogs, based on routine biochemical diagnostic methods

67%
Kasprowicz A., Bialecka A., Bialecka J., Godzisz I., Barabasz W., Jaworska O., Malachowa N., Miedzobrodzki J.
Polish Journal of Microbiology
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2011
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tom 60
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nr 1
To determine the staphylococcal colonization pattern in healthy and diseased dogs, living in two particular environments, a number of microbiological samples were taken. Overall, twenty dogs, either healthy or with infected skin lesions, were examined. In each case bacterial swabs were collected from the nasal mucosa, ear, perineum, lumbo-sacralis triangle, and from the infection sites if such were present. A total number of 104 isolates representing different staphylococcal species were isolated and identified using routine biochemical methods applied in diagnostic laboratories. Among 17 isolated staphylococcal species, Staphylococcus intermedius was the most common species isolated from both healthy or diseased dogs living either in animal shelter or household environments. The pattern of Staphylococcus sp. colonization differs considerably for animals living in the two tested habitats. In particular, S. aureus MRSA and MSSA isolates were detected only in infected skin lesion samples from animals that dwelled in the animal shelter. As could be expected, S. intermedius was found to be a predominant causative agent in canine skin infections. In our study, we demonstrated that S. intermedius in its carrier-state, inhabits mainly the mucosal membrane of the nasal vestibule. It was also found in the samples taken from the skin, the lumbo-sacralis triangle and perineum, but was rarely isolated from the ears.
9

Cytology of nasal mucosa, olfactometry and rhinomanometry in patients after CO2 laser mucotomy in inferior turbinate hypertrophy

67%
Olszewska E., Sieskiewicz A., Kasacka I., Rogowski M., Zukowska M., Soroczynska J., Rutkowska J.
Folia Histochemica et Cytobiologica
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2010
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tom 48
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nr 2
217-221
10
Content available remote

Influence of stimulation of nasal afferents on expiration reflex evoked from vocal folds

67%
Plevkova J., Antosiewicz J., Poliacek I., Adamkov M., Jakus J., Svirlochova K., Tatar M.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 5
11
Content available remote

Cytological assessment of the epithelial cells of the nasal mucous membrane after local fluticasone therapy

67%
Trybus E., Krol T., Obarzanowski T., Trybus W., Kopacz-Bednarska A., Obarzanowski M.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 1
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