The purpose of the study was determination of the effects of joint administration of antioxidant vitamins and mono and polyunsaturated fatty acids on the development of experimental atherosclerosis in rabbits. The experiment was carried out on 40 rabbits divided into 4 groups. Groups A, B, C, received stock diet with added cholesterol 0,2 g per 100 g of diet, in group B the diet was supplemented with rapaseed and sunflower oil besides cholesterol, group C was given 500 mg of vitamin C, 150 mg of vitamin E, 50 mg of beta-carotene besides cholesterol and oils per 100 g of diets. The control group - D, received stock diet with addition of the studied oils and vitamins. The experiment lasted 12 weeks. The mean area of lipid lesions in the aorta of the rabbits receiving the atherogenic diet was 18.1 ± 10.1%. The addition of vegetable oils to cholesterol-rich diet reduced this area to 14.0 ± 8.6%. The smallest lipid lesions (1.9 ± 1.3%) were in the animals receiving cholesterol-rich diet supplemented with antioxidant vitamins and vegetable oils. It was found also that cholesterol consumption was the highest in that group. The results of the experiment show that atherogenic processes in rabbits depend on many factors and are not directly proportional to the amount of cholesterol taken with diet and cholesterol concentration in serum.
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