Wyniki wyszukiwania

1

The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide

100%

Papiez M. A., Krzysciak W.

Acta Biochimica Polonica

|

2014

|

tom 61

|

nr 4

2

Effect of bacterial extract, IRS-19, on the concentration of hydrogen peroxide and myeloperoxidase activity in nasal washings of patients with chronic bronchitis

100%

Nowak D., Prozynski M., Pietras T., Stolarek R., Mazerant P., Leder M.

Archivum Immunologiae et Therapiae Experimentalis

|

1997

|

tom 45

|

nr 1

3

Characterization of 'unhealed gastric ulcers' produced with chronic exposure of acetic acid ulcers to indomethacin in rats

100%

Amagase K., Yokota M., Tsukimi Y., Okabe S.

Journal of Physiology and Pharmacology

|

2003

|

tom 54

|

nr 3

We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation. The present study examined the mechanism underlying such "unhealed gastric ulcers" with biochemical and histological procedures. "Unhealed gastric ulcers" were induced with a 4-wk indomethacin treatment (1 mg/kg, twice daily) in rats with acetic acid ulcers. Two and 4 wks after treatment cessation, ulcer size was significantly larger in rats receiving indomethacin compared with control animals. Ulcerated tissue prostaglandin E2 levels were significantly lower during indomethacin treatment, but the levels tended to increase after treatment cessation compared with levels measure in the group receiving vehicle. Myeloperoxidase activity levels were significantly higher during indomethacin treatment; such levels persisted after treatment cessation. Histologically, greater degrees of fibrosis and neutrophil accumulation, as well as a lesser degree of angiogenesis were observed in the "unhealed gastric ulcers" compared to ulcers that healed in a normal fashion. It was concluded that severe fibrosis, persistent neutrophil infiltration, and poor angiogenesis in the ulcer base might represent factors involved in the mechanism underlying production of "unhealed gastric ulcers".

4

Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice

80%

Harusato A., Naito Y., Takagi T., Yamada S., Mizushima K., Hirai Y., Horie R., Inoue K., Fukumoto K., Hirata I., Omatsu T., Kishimoto E., Uchiyama K., Handa O., Ishikawa T., Kokura S., Ichikawa H., Muto A., Igarashi K., Yoshikawa T.

Journal of Physiology and Pharmacology. Supplement

|

2009

|

tom 60

|

nr 7

5

Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons

80%

Sano T., Utsumi D., Amagase K., Matsumoto K., Tominaga M., Higuchi K., Takeuchi T., Kato S.

Journal of Physiology and Pharmacology

|

2017

|

tom 68

|

nr 1

6

The effects of disodium pamidronate on human polymorphonuclear leukocytes and platelets: an in vitro study

80%

Salvolini E., Orciani M., Vignini A., Di Primo R., Mazzanti L.

Cellular and Molecular Biology Letters

|

2009

|

tom 14

|

nr 3

457-465

Recent reports have indicated that, as well as having antiresorptive effects, bisphosphonates could have an application as anti-inflammatory drugs. Our aim was to investigate whether this anti-inflammatory action could be mediated by the nitric oxide (NO) released by the leukocytes migrating to the site of inflammation. In particular, we investigated in vitro the intracellular calcium concentration ([Ca2+]i), the level of NO released by PMN and platelets, and the PMN myeloperoxidase activity after incubation with disodium pamidronate, since there was a postulated modulatory effect of this aminosubstituted bisphosphonate on leukocytes both in vitro and in vivo. Our data shows that the pamidronate treatment provoked a significant increase in the [Ca2+]i parallel to the enhancement in NO release, suggesting a possible activation of constitutive nitric oxide synthase, while the myeloperoxidase activity was significantly reduced. In conclusion, we hypothesized that treatment with pamidronate could stimulate NO-production by cells present near the bone compartment, thus constituting a protective mechanism against bone resorption occurring during inflammation. In addition, PMN- and platelet-derived NO could act as a negative feed-back signal to restrict the inflammatory processes.

Ograniczanie wyników

The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide

Effect of bacterial extract, IRS-19, on the concentration of hydrogen peroxide and myeloperoxidase activity in nasal washings of patients with chronic bronchitis

Characterization of 'unhealed gastric ulcers' produced with chronic exposure of acetic acid ulcers to indomethacin in rats

Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice

Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons

The effects of disodium pamidronate on human polymorphonuclear leukocytes and platelets: an in vitro study