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  1. 12 Journal of Physiology and Pharmacology

  2. 5 Archivum Immunologiae et Therapiae Experimentalis

  3. 4 Folia Histochemica et Cytobiologica

  4. 3 Polish Journal of Veterinary Sciences

  5. 2 Acta Biochimica Polonica

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Autorzy help

  1. 3 Takeuchi K.

  2. 3 Wessely-Szponder J.

  3. 2 Deptula W.

  4. 2 Marcinkiewicz J.

  5. 2 Tanaka A.

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  1. 1 2020

  2. 1 2019

  3. 1 2017

  4. 2 2016

  5. 1 2015

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1

The biosynthesis of neutrophil and eosinophil granule proteins

100%
Olsson I., Egesten A., Gullberg U., Lantz M., Stromberg K., Winqvist I.
Folia Histochemica et Cytobiologica
|
1986
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tom 24
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nr 2
2
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Content available

Experimental inflammatory bowel disease - role of T cells

100%
Szczepanik M., Gryglewski A., Bryniarski K., Stachura J., Ptak W.
Journal of Physiology and Pharmacology
|
2000
|
tom 51
|
nr 2
3

Oxidative modification of type II collagen differentially affects its arthritogenic and tolerogenic capacity in experimental arthritis

100%
Marcinkiewicz J., Biedron R., Maresz K., Kwasny-Krochin B., Bobek M., Kontny E., Maslinski W., Chain B.
Archivum Immunologiae et Therapiae Experimentalis
|
2004
|
tom 52
|
nr 4
4
Content available remote

Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis

84%
Krajewska J. B., Pietruszka P., Tomczyk D., Chen C., Owczarek A., Karolewicz B., Czapor-Irzabek H., Gorniak A., Fichna J.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 2
5

Myenteric plexuses atrophy in the vicinity of colorectal cancer tissue is not caused by apoptosis or necrosis

84%
Kozlowska A., Kwiatkowski P., Oponowicz A., Majewski M., Kmiec Z., Godlewski J.
Folia Histochemica et Cytobiologica
|
2016
|
tom 54
|
nr 2
6

The NADPH oxidase family and its inhibitors

84%
Kleniewska P., Piechota A., Skibska B., Goraca A.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 4
7
Content available remote

The role of local and systemic cytokines in patients infected with Clostridium difficile

84%
Czepiel J., Biesiada G., Brzozowski T., Ptak-Belowska A., Perucki W., Birczynska M., Jurczyszyn A., Strzalka M., Targosz A., Garlicki A.
Journal of Physiology and Pharmacology
|
2014
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tom 65
|
nr 5
8

The influence of isoprivet on neutrophil secretory action in the course of BRD in calves

84%
Wessely-Szponder J., Kloc K.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2010
|
tom 13
|
nr 4
9
Content available remote

Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats

84%
Hayashi S., Kurata N., Kitahirachi E., Nishimura Y., Amagase K., Yano T., Takeuchi K.
Journal of Physiology and Pharmacology
|
2013
|
tom 64
|
nr 4
10

The effect of shepherd's purse extract (Capsella bursa pastoris (L.) Medik.) on the activity of some enzymatic systems essential for defensive function of granulocytes

84%
Rzadkowska-Bodalska H., Olechnowicz-Stepien W., Gasiorowski K.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1987
|
tom 35
|
nr 10-12
11

Non-specific humoral immunity in rabbits immunised with Chlamydia psittaci - Gocaltovo strain

84%
Pawlikowska M., Deptula W.
Polish Journal of Veterinary Sciences
|
2003
|
tom 06
|
nr 3 Suppl.
12
Content available remote

Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage

84%
Takeuchi K., Tanaka A., Ohno R., Yokota A.
Journal of Physiology and Pharmacology. Supplement
|
2003
|
tom 54
|
nr 4
165-182
Nonsteroidal antiinflammatory drugs (NSAIDs) such as indomethacin decrease mucosal PGE2 production by inhibiting cyclooxygenase (COX) activity and produce damage in the small intestine. The development of intestinal lesions as induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression. Neither the selective COX-1 inhibitor, SC-560, nor the selective COX-2 inhibitor, rofecoxib, alone caused intestinal damage, but their combined administration produced lesions. SC-560, but not rofecoxib, caused intestinal hypermotility, bacterial invasion and the expression of COX-2 as well as iNOS mRNAs, yet the iNOS and MPO activity was increased only when rofecoxib was administered together with SC-560. Although SC-560 inhibited the PG production, the level of PGE2 was recovered, in a rofecoxib-dependent manner. The intestinal hypermotility response to indomethacin was prevented by both 16,16-dimethyl PGE2 and atropine but not ampicillin, yet all these agents inhibited not only the bacterial invasion but also the expression of COX-2 as well as the iNOS activity in the intestinal mucosa following indomethacin treatment, resulting in preventing the intestinal lesions. These results suggest that inhibition of COX-1, despite causing intestinal hypermotility, bacterial invasion and iNOS expression, up-regulates the expression of COX-2, and the PGE2 derived from COX-2 counteracts deleterious events caused by COX-1 inhibition and maintains the mucosal integrity. These sequences of events explain why intestinal damage occurs when both COX-1 and COX-2 are inhibited.
13
Content available remote

Anti-inflammatory effects of nesfatin-1 in rats with acetic acid - induced colitis and underlying mechanisms

84%
Ozturk C. C., Oktay S., Yuksel M., Akakin D., Yarat A., Kasimay Cakir O.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 5
14

Assessment of neutrophil components as markers of lung injury in the course of bovine respiratory tract infections

84%
Wessely-Szponder J., Bobowiec R., Martelli F., Wojcik M., Kosior-Korzecka U.
Polish Journal of Veterinary Sciences
|
2004
|
tom 07
|
nr 3
To define the role of activated neutrophils in lung injury during bovine respiratory tract infections (BRTI) their in vitro function was investigated. As a means to achieve this goal the comparison of secretory action between neutrophils from the BRTI group and control was made on the basis of elastase, myeloperoxidase (MPO), alkaline phosphatase (ALK-P) release, and nitric oxide production. We noted that there is an interdependence between secretory response of neutrophils and clinical severity of BRTI. The release of elastase was greater in the BRTI group than in the control group (49.17 ±4.41 versus 46.43 ±4.95% of the total content). Neutrophils from infected heifers exhibited a significantly (p<0.05) higher value of MPO release than from healthy heifers and reached 39.23 ± 10.18 versus 25.54 ± 8.41% of the total content. ALK-P containing granules released significantly (p<0.001) more enzyme in the group with BRTI than in the control group (22.42 ± 6.27 versus 13.74 ± 2.01% of the total enzyme content). The level of nitrite accumulation rose in the culture of cells isolated from heifers with BRTI from 4 ± 0.53 μM after 0.5h to 6.9 ± 0.52 μM after 72 h. Our data suggest that during BRTI the increase of neutrophil secretory action results in augmentation of enzyme release including elastase, MPO and ALK-P, and the nitrite production. During an excessive secretory response of neutrophils all these factors contribute to lung injury and worsen the course of a disease and might be recognised as markers of lung injury. Moreover, such a destructive action of neutrophils must be taken into account during the introduction of new methods of BRTI treatment.
15

Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses

84%
El-Benna J., My-Chan Dang P., Gougerot-Pocidalo M. A., Elbim C.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
|
tom 53
|
nr 3
16

Inactivation and denaturation of some proteins by enzyme system: myeloperoxidase, chloride and hydrogen peroxide

84%
Drozdz R., Naskalski J. W.
Folia Histochemica et Cytobiologica
|
1993
|
tom 31
|
nr 2
17
Content available remote

Anti-inflammatory effects of nesfatin-1 on acetic acid-induced gastric ulcer in rats: involvement of cyclo-oxygenase pathway

67%
Kolgazi M., Ozdemir-Kumral Z. N., Cantali-Ozturk C., Demirci E. K., Yuksel M., Sirvanci S., Yegen B. C.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 5
18
Content available remote

Effects of peroxisome proliferator-activated receptors-gamma ligands on dextran sodium sulphate-induced colitis in rats

67%
Celinski K., Dworzanski T., Korolczuk A., Piasecki R., Slomka M., Madro A., Fornal R.
Journal of Physiology and Pharmacology
|
2011
|
tom 62
|
nr 3
Recent studies indicate the involvement of peroxisone proliferator-activated receptor- (PPAR-) in the inflammatory reaction. The exact mechanism of PPAR- action has not been elucidated. It is supposed that PPAR- regulates transcription of genes responsible for encoding cytokines involved in the inflammatory response. The latest studies, carried out to explain the pathogenesis of non-specific colitis, confirm beneficial effects of PPAR- agonists on attenuation of colon inflammation. The aim of the present study was to assess the effects of nuclear PPAR- activity on the course of experimental acute colitis induced by intragastric administration of dextran sodium sulphate (DSS) using the PPAR- agonist rosiglitazone and the antagonist BADGE in rats. Colitis in Wistar rats was induced by 1.5% DSS administered in drinking water for 8 days. Animals with induced colitis received rosiglitazone, bisphenol A diglycidyl ether (BADGE) or both substances. After decapitation, colons were macroscopically and histopathologically evaluated. Levels of interleukin-1ß (IL-1ß), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor- (TNF-) and myeloperoxidase (MPO) were determined in serum and colon homogenates using ELISA. In rats with experimentally induced colitis receiving rosiglitazone, the inflammatory reaction was found to be markedly limited; ulceration, oedema and infiltration activity were reduced. The activated PPAR- inhibit the expression of proinflammatory factors, such as IL-6, TNF-, and neutrophil chemotaxis, which was evidenced by MPO reduction in serum and colon homogenates mediated by rosiglitazone. The positive effects of rosiglitazone on expression of IL-10 were also demonstrated. During the short period of observation, BADGE did not increase histopathological inflammatory markers.
19

The effect of TNFalpha on the production of nitric oxide by neutrophils isolated from heifers in the course of bovine respiratory disease

67%
Wessely-Szponder J.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2007
|
tom 10
|
nr 4
20

Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects

67%
Serrano J., Cipak A., Boada J., Gonzalo H., Cacabelos D., Cassanye A., Pamplona R., Zarkovic N., Portero-Otin M.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 2
 A previous report from our group had shown in vitro a direct interaction between peroxidases and dietary antioxidants at physiological concentrations, where in the absence of H2O2, the antioxidants could serve as oxidizing substrates for the peroxidases. However, the physiological relevance of those findings had not been evaluated. The main objective of this study was to determine whether the oxidizing products produced in the interaction between peroxidase and gallic acid at a physiological concentration of 1 μM may promote cell death or survival in a human microvascular endothelial cell line (HMEC-1). Our findings suggested that gallic acid may show a double-edged sword behaviour, since in the absence of H2O2 it may have a pro-oxidant effect which may promote cell injury (evidenced by LDH, Crystal Violet and calcein AM viability/citotoxicity assays), while in the presence of H2O2, gallic acid may act as an antioxidant inhibiting oxidative species produced in the peroxidase cycle of peroxidases. These observations were confirmed with several oxidative stress biomarkers and the evaluation of the activation of cell survival pathways like AKT and MAPK/ERK.
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