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How accurate is spirometry at predicting restrictive pulmonary impairment in children with myasthenia gravis

100%
Zielonka T., Kostera-Pruszczyk A., Ryniewicz B., Korczynski P., Szyluk B.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 4
409-416
Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction. Clinical symptoms are caused by weakness and increased fatigability of various muscle groups. Myasthenia may lead to significant respiratory dysfunction. The aim of our study was to estimate lung function in children with MG. We tested 23 non-smoking patients (18 girls and 5 boys) aged 7-18 years. Whole-body plethysmography and spirometry were performed in all patients. In 33% of the patients a decrease in VC <80% of predicted value was observed (VC = 89 ±19%), but the analysis of TLC revealed restrictive pattern only in one patient (TLC = 102 ±17%). In more than 75% of the children the value of RV above 120% of predicted value was found (RV = 146 ±54%). Spirometric obstructive pattern measured by FEV1%VC <70% was not observed, although in 56% of the patients airway resistance was increased (Raw = 132 ±44%). In 45% of the patients a decrease of PEF (76 ±14%) was observed. In MG children true restrictive pulmonary impairment is rarely observed and a decrease in VC in these patents seems to result mainly from functional restriction provoked by an increase in RV. Spirometry is not an optimum method to assess functional changes in MG patients. The assessment of additional measures such as TLC, RV, and Raw is desirable.
2
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Diagnostic and therapeutic challenges of myasthenia gravis: a report of 2 cases

100%
Poleszek J., Szabat P., Jasielski P., Szabat M., Petit V., Fidor A., Rejdak K.
World News of Natural Sciences
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2020
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tom 31
3

Myoid cells and neuroendocrine markers in myasthenic thymuses

100%
Zoltowska A., Pawelczyk T., Stopa M., Skokowski J., Stepinski J., Roszkiewicz A., Nyka W.
Archivum Immunologiae et Therapiae Experimentalis
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1998
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tom 46
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nr 4
4

Immunological system status and the appearance of respiratory system disturbances in thymectomized patients

100%
Krawczyk P., Adamczyk-Korbel M., Kieszko R., Korobowicz E., Milanowski J.
Archivum Immunologiae et Therapiae Experimentalis
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2007
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tom 55
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nr 1
5

Familial form of autoimmune myasthenia gravis in a dog: a case report

80%
Drzewiecka A., Pazdzior K., Rotkiewicz T., Lew S., Kwiatkowska M.
Medycyna Weterynaryjna
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2011
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tom 67
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nr 05
This paper describes clinical and pathomorphological features of myasthenia gravis in a 7-year-old male German Shepherd dog. At clinical examination, many neurological deficits as well as swallowing and urinating problems were detected. Radiological examination revealed megaoesophagus and the ELISA test showed an elevated serum acetylcholine receptor (AChR) antibody titer. No improvement was observed after the administration of edrophonium hydrochloride. The diagnosis of myasthenia gravis was confirmed by electromyography. Despite the administration of pyridostygmine bromide, dexamethasone and antibiotics, no improvement followed, and the dog died. Necropsy was conducted: histopathological changes in the esophagus, cranial tibial muscle and lungs were described as muscular atrophy, muscular fibrosis and aspiration pneumonia. The dog’s littermate was examined and showed an elevated AChR antibody titer too, but was asymptomatic.
6

Acetylcholine receptor-induced experimental myasthenia gravis: what have we learned from animal models after three decades?

80%
Baggi F., Antozzi C., Toscani C., Cordiglieri C.
Archivum Immunologiae et Therapiae Experimentalis
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2012
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tom 60
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nr 1
7

Myasthenia, spondylitis and Enterococcus faecalis endocarditis

80%
Stollberger C., Thalmann M., Finsterer J.
Archivum Immunologiae et Therapiae Experimentalis
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2012
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tom 60
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nr 3
8

Immunomodulatory activity of G-actin fragments containing a thymopentin-like sequence

80%
Siemion I. Z., Strug I., Wyslouch-Cieszynska A., Nowak E., Wieczorek Z.
Archivum Immunologiae et Therapiae Experimentalis
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1997
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tom 45
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nr 5-6
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