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Application of multiplex FISH, CGH and MSSCP techniques for cytogenetic and molecular analysis of transitional cell carcinoma [TCC] cells in voided urine specimens

100%

Constantinou M., Binka-Kowalska A., Borkowska E., Zajac E., Jalmuzna P., Matych J., Nawrocka A., Kaluzewski B.

Journal of Applied Genetics

2006

tom 47

nr 3

Multiplex FISH (UroVysion), Comparative Genomic Hybridization (CGH), and Multitemperature Single-Strand Conformation Polymorphism (MSSCP) were applied for non-invasive diagnosis and prognosis of bladder cancer. The UroVysion test was positive in 80% of patients with pTl and in 100% of patients with either pT2 or pT3 tumours. Tumours with pT3T4 stages were characterized by high numbers of chromosomal imbalances, detected by CGH. The mutation of the p53 gene was detected in 16% of patients, but only in those with pT2 or pT3 tumours.

Ograniczanie wyników

1 Journal of Applied Genetics

1 Binka-Kowalska A.

1 Borkowska E.

1 Constantinou M.

1 Jalmuzna P.

1 Kaluzewski B.

1 Matych J.

1 Nawrocka A.

1 Zajac E.

1 2006

Wyniki wyszukiwania

Application of multiplex FISH, CGH and MSSCP techniques for cytogenetic and molecular analysis of transitional cell carcinoma [TCC] cells in voided urine specimens