Wyniki wyszukiwania

1

Modulation of the avian immune system: suppression versus induction of immunity

100%

Rautenschlein S., Neumann U.

Polish Journal of Veterinary Sciences

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2004

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tom 07

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nr 1

2

Growth rate modulation enables coexistence in a competitive exclusion scenario between microbial eukaryotes

86%

Ribeiro G. M., Prado P. I., Coutinho R. M., Rillo M. C., Pereira jr. S., Poreirio-Sousa A. L., Lahr D. J. G.

Acta Protozoologica

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2019

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tom 58

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nr 4

3

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Impacts of modulation for direct payments in Hungary

86%

Vasary M., Molnar J., Zsolt B.

Roczniki Naukowe Stowarzyszenia Ekonomistów Rolnictwa i Agrobiznesu

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2013

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tom 15

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nr 4

The redeployment of subsidies through modulation was a new element in the system of Hungarian agricultural support in the premium year of 2012. In harmony with EU principles, it has become possible (within Hungarian implementation) to create a system which enables the radical moderation of actual volumes of subsidy redeployment resulting from modulation. The basis of model calculations was created by the finalized data of ARDA about payments in the premium year of 2011. Following the running of calculations, it can be confirmed that the implementation of the Hungarian method has resulted in reduced payments only in the case of 2% of all farmers eligible for direct subsidies, and about 10% of those who are actually involved in payment reduction.

4

Modulation of murine macrophages and T lymphocytes by lysozyme dimer

86%

Obminska-Mrukowicz B., Szczypka M., Gaweda B.

Polish Journal of Veterinary Sciences

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2002

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tom 05

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nr 4

The effects of lysozyme dimer (2 and 20 μg/kg) administered i.p. once and four times to mice on the phagocytic and killing ability of peritoneal macrophages, interleukin-1 (IL-1) production by murine macrophages stimulated in vitro with lipopolisaccharide of E. coli and expression of thymocyte, splenocyte and mesenteric lymphonode cell CD3+, CD4+ and CD8+ markers were studied. It was found that lysozyme dimer administered once or four times at doses of 2 (μg/kg and 20 μg/kg augments the phagocytic and killing activity of peritoneal macrophages. The strongest stimulating effect was noted after four injections of lysozyme dimer at a dose of 20 μg/kg. Moreover, lysozyme dimer is able to modulate the production of IL-1 by murine macrophages stimulated in vitro with LPS. Exposure to four doses of lysozyme dimer (20 μg/kg) enhances the synthesis and release of IL-1, but this drug administered once (2 μg/kg and 20 μg/kg) or four times (2 μg/kg) decreases IL-1 production by peritoneal macrophages. It was also found that administration of lysozyme dimer at a dose of 20 μg/kg, irrespective of the number of doses applied, increases the percentage of CD4+ thymocytes and splenocytes. Moreover, exposure to four doses of lysozyme dimer (2 and 20 μg/kg) increases the percentage of CD4+ and CD8+ mesenteric lymphonode cells.

5

Corticotrophin releasing factor modulates the morphine effect on the mu, delta and kappa opioid receptor agonist binding in lamb hypothalamic-pituitary-adrenal axis

86%

Pierzchala-Koziec K., Zubel-Lojek J., Latacz A., Oclon E.

Prace Komisji Nauk Rolniczych, Leśnych i Weterynaryjnych. Polska Akademia Umiejętności

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2015

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tom 21

6

Modulation of CD40L antigen expression in Jurkat cells: involvement of protein kinase C activity

86%

Lisowska K., Bryl E., Soroczynska M., Witkowski J. M.

Folia Histochemica et Cytobiologica

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2003

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tom 41

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nr 4

7

Farnesyl diphosphate synthase: regulation of product specificity

86%

Szkopinska A., Plochocka D.

Acta Biochimica Polonica

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2005

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tom 52

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nr 1

Farnesyl diphosphate synthase (FPPS) is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. It catalyzes the sequential head-to-tail condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopentenyl diphosphate per homodimer. The synthase amino-acid residues at the 4th and 5th positions before the first aspartate rich motif mainly determine product specificity. Hypothetically, type I (eukaryotic) and type II (eubacterial) FPPSs evolved from archeal geranylgeranyl diphosphate synthase by substitutions in the chain length determination region. FPPS belongs to enzymes encoded by gene families. In plants this offers the possibility of differential regulation in response to environmental changes or to herbivore or pathogen attack.

8

Modulation of the immune response by extracellular matric proteins

86%

Morwood S. R., Nicholson L. B.

Archivum Immunologiae et Therapiae Experimentalis

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2006

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tom 54

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nr 6

9

CD3 receptor modulation in Jurkat leukemic cell line

86%

Jozwik A., Soroczynska M., Witkowski J. M., Bryl E.

Folia Histochemica et Cytobiologica

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2004

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tom 42

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nr 1

10

Modulation of testicular macrophage activity by collagenase

86%

Bryniarski K., Szczepanik M., Ptak M., Ptak W.

Folia Histochemica et Cytobiologica

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2005

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tom 43

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nr 1

11

Relative roles of photoperiodic and nutritional cues in modulating ovarian activity in goats

72%

Urrutia-Morales J., Meza-Herrera C. A., Escobar-Medina F. J., Gamez-Vazquez H. G., Ramirez-Andrade B. M., Diaz-Gomez M. O., Gonzalez-Bulnes A.

Reproductive Biology

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2009

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tom 09

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nr 3

12

Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids

72%

Wesolowska O., Hendrich A. B., Lania-Pietrzak B., Wisniewski J., Molnar J., Ocsovszki I., Michalak K.

Cellular and Molecular Biology Letters

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2009

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tom 14

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nr 2

199-221

The expression of transmembrane transporter multidrug resistance-associated protein 1 (MRP1) confers the multidrug-resistant phenotype (MDR) on cancer cells. Since the activity of the other MDR transporter, P-glycoprotein, is sensitive to membrane perturbation, we aimed to check whether the changes in lipid bilayer properties induced by flavones (apigenin, acacetin) and flavonols (morin, myricetin) were related to their MRP1 inhibitory activity. All the flavonoids inhibited the efflux of MRP1 fluorescent substrate from human erythrocytes and breast cancer cells. Morin was also found to stimulate the ATPase activity of erythrocyte ghosts. All flavonoids intercalated into phosphatidylcholine bilayers as judged by differential scanning calorimetry and fluorescence spectroscopy with the use of two carbocyanine dyes. The model of an intramembrane localization for flavones and flavonols was proposed. No clear relationship was found between the membrane-perturbing activity of flavonoids and their potency to inhibit MRP1. We concluded that mechanisms other than perturbation of the lipid phase of membranes were responsible for inhibition of MRP1 by the flavonoids.

13

Seed priming improves salt stress tolerance during germination by modulation of antioxidative capacity

72%

Kubala S., Wojtyla L., Garnczarska M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 2

14

The modulation of HIFs, pluripotency and differentiation genes expression by oxygen conditions in neural stem cells derived from human cord blood

72%

Szablowska-Gadomska I., Drela K., Podobinska M., Ziemka-Nalecz M., Domanska-Janik K., Buzanska L.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

The oxygen tension is an important factor modulating cell fate and developmental decisions. There are evidences that HIFs (Hypoxia Inducible Factors) family is implicated in the regulation of pluripotency and differentiation genes. The goal of this study is to compare the influence of close to physiological oxygen conditions (5%) to atmospheric oxygen tension on differentiation process and pluripotent activity in HUCB-NSC. The expression of Hypoxia Inducible Factors, stemness and neural differentiation markers in NSC, cultured under 5% and 21% oxygen were checked on the transcriptional and translational level. We were looking at the interaction between HIFs (HIF1 alpha, HIF 2 alpha) and activity of neural differentiations genes (MAP2, GFAP, β-tubulin) as well as expression of pluripotency genes (Oct4, Sox2, Rex1 and Nanog). In order to demonstrate the impact of increased HIF1α and/ or HIF2α level on cell differentiation we used DMOG (Sigma) which is of prolyl-4-hydroksylase inhibitor to increase HIF alpha levels. Our data show, that low oxygen conditions promote proliferation of HUCBNSC at early stage of development and can activate Oct4 and Nanog genes in HUCB-NSC. The time of cultivation of the cells in low oxygen conditions and the developmental stage of the cells are the important factors for the induction of the expression of “pluripotency” genes.Hypoxia Inducible Factors HIF 1α and HIF 2α, but not HIF3α are expressed in HUCB-NSC at all stages of development. During neuronal differentiation of HUCB-NSC by using dBcAMP, 5% oxygen level act synergistically, promoting further differentiation (enhanced MAP2 expression). Application of prolyl hydroxylase inhibitor – DMOG resulted in increased expression of HIF1α but not HIF2α and increased the expression of MAP2 (only in 21% oxygen conditions) referring to variants without DMOG. Sponsored by grant from Polish Ministry of Scientific Research and Higher Education No N N302 597838 and by NSC grant No 2011/01/B/NZ3/05401

15

Viral strategies in modulation of NF-kappaB activity

72%

Lisowska K., Witkowski J. M.

Archivum Immunologiae et Therapiae Experimentalis

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2003

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tom 51

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nr 6

16

Screening and modulation of extracellular signals by mucous barrier. Serum glycosylphosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa

72%

Slomiany A., Nishikawa H., Slomiany B. L.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 1

Performance of mucosal epithelial barrier is modified by numerous agents that exert effects on mucin-Mucin Binding Protein (MBP)complex.The aim of the studies described was to determine the nature of the damage or modification of oral mucous barrier by the short-term exposure to ethanol.Methods:Culture of rat buccal mucosa in the presence of ethanol and [3H]-labeled proline and palmitate revealed substantial decrease in MBP synthesis and the release of MBP to the medium.The radioscanning of the samples prepared from the culture medium and the apical epithelial membranes subjected to SDS- PAGE and western blotting disclosed that the released,water soluble 97kDa MBP glycopeptide was labeled with proline and palmitate.When the experiments were conducted in the presence of 5mM EDTA,the GPI-PLD inhibitor,the majority of radiolabeled MBP remained in the membrane-bound form and was extractable with Triton X-114.The results on the purified GPI-linked MBP degradation by serum enzyme,by the saliva containing serum transudate,and the suppression of the process by inclusion of GPI-PLD-specific inhibitor support our contention that membrane MBP is released to medium by GPI-PLD- like activity.Results:The release of MBP from apical epithelial surfaces was induced by depletion of mucin and the presence of serum-derived GPI-PLD in the tissue homogenate. Strong likelihood exists that under in situ conditions ethanol-induced transudation of serum to saliva provides the vehicle for the transfer of GPI-PLD activity to salivary contents. Defacement of the oral surfaces from mucous barrier signals prospect of lumenal agent influence on the unprotected epithelial exterior,and allows ingression of microbes and untoward acting substances into the organism.

17

Modulation of acute phase protein synthesis by cellular growth and differentiation factors

72%

Koj A., Rokita H., Pierzchalski P., Kordula T., Guzdek A., Bereta J.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

18

Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P

72%

Kozakiewicz M., Godlewski A.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 3

To assess the effect of substances inducing mast cell degranulation (substance P and granuliberin R) on the mitotic indices of the gingiva stratified epithelium, basal cells from rats were studied in vivo. Seventy Lewis male rats were used in the study. The rats received injections of either 0.1 ml 0.9% NaCl (10 rats), or substance P (10-4,10-6, 10-8 g/ml) (30 rats), or granuliberin R (10-4,10-6, 10-8 g/ml) (30 rats) into their mandibular gingiva in the vicinity of the right mental foramen. The mitotic index of keratinocytes was established after the kolchicine arrest (2 hours prior to material collection i.p. injection). The number of cells in metaphase was counted on 1000 consecutive basal layer cells after hematoxilin and eosin section staining. Mast cells were revealed using pinocyanol erythrosinate according to Bensley. Numerical density and morphometric features were analyzed. Substance P and granuliberin R injected into the gingiva affect the mast cells and the basal cell proliferation of the gingival epithelium. The diminished mitotic activity of basal layer cells was accompanied by degranulation and/or migration of mast cells under the basal membrane of the epithelium. After administration of high doses of granuloliberin R, mast cells were found in the deep connective tissue alligned towards the epithelium. A neuromediator from the trigeminal nerve (substance P) and substances from mast cells actively interfere in the proliferation of oral keratinocytes and the activity of connective tissue cells.

19

Modulation of auxiliary signals to T cells as a mechanism to induce transplant tolerance

72%

Gorczynski R. M.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

|

nr 2

20

Modulation of apoptosis signalling for cancer therapy

72%

Fulda S., Debatin K. M.

Archivum Immunologiae et Therapiae Experimentalis

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2006

|

tom 54

|

nr 3

Ograniczanie wyników

Modulation of the avian immune system: suppression versus induction of immunity

Growth rate modulation enables coexistence in a competitive exclusion scenario between microbial eukaryotes

Impacts of modulation for direct payments in Hungary

Modulation of murine macrophages and T lymphocytes by lysozyme dimer

Corticotrophin releasing factor modulates the morphine effect on the mu, delta and kappa opioid receptor agonist binding in lamb hypothalamic-pituitary-adrenal axis

Modulation of CD40L antigen expression in Jurkat cells: involvement of protein kinase C activity

Farnesyl diphosphate synthase: regulation of product specificity

Modulation of the immune response by extracellular matric proteins

CD3 receptor modulation in Jurkat leukemic cell line

Modulation of testicular macrophage activity by collagenase

Relative roles of photoperiodic and nutritional cues in modulating ovarian activity in goats

Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids

Seed priming improves salt stress tolerance during germination by modulation of antioxidative capacity