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For targeted drug delivery a variety of protector or carrier systems has been developed. One of the promising approaches uses liposomes, which may be partially directed toward particular types of cells by means of antibodies or other ligands. We have proposed recently a new method for drug targeting based on magnetoliposomes, which are liposomes with subdomain magnetite (Fe3O4) particles with a diameter of ≈10 nm incorporated in their bilayers. Due to their magnetic sensitivity a non-homogeneous magnetic field may be used for the targeting of magnetoliposomes to a given tissue. Because magnetite particles are strong microwave absorbers we have experimentally analyzed the influence of microwave radiation with a frequency of 2.45 GHz on the permeability of phosphatidylcholine magnetoliposomes. We have found for example that microwave radiation with specific absorbed power of 400 mW/g almost completely releases entrapped 6-carboxy-fluorescein in 15 min. The probable underlying mechanism is heating of Fe3O4 particles which leads to a perforation of lipid bilayers and subsequent leakage of entrapped magnetoliposome volume, so microwave radiation may be used for controllable release of drugs at low doses of microwave radiation intensities as compared with conventional microwave hyperthermia used previously by other authors.
The effects of microwave radiation on viability of fungal and actinomycetal spores growing on agar (medium optimal for growth) as well as on wooden panel and drywall (common building construction/fi nishing materials) were studied. All materials were incubated at high (97-99%) and low (32-33%) relative humidity to mimic “wet” and “dry” environmental conditions. Two microwave power densities (10 and 60 mW/cm2) and three times of exposure (5, 30, and 60 min) were tested to fi nd the most effective parameters of radiation which could be applied to non-invasive reduction or cleaning of building materials from microbial contaminants. Additionally, a control of the surface temperature during the experiments allowed differentiation between thermal and microwave effect of such radiation. The results showed that the viability of studied microorganisms differed depending on their strains, growth conditions, power density of microwave radiation, time of exposure, and varied according to the applied combination of the two latter elements. The effect of radiation resulting in a decrease of spore viability on “wet” wooden panel and drywall was generally observed at 60 min exposure. Shorter exposure times decreased the viability of fungal spores only, while in actinomycetes colonizing the studied building materials, such radiation caused an opposite (supporting growth) effect.
Providing the optimal temperature is a means of increasing the effectiveness of methane fermentation processes. The use of an electromagnetic microwave field enables energy to be directed to a mixture of anaerobic sludge and processed biomass this reduces energy losses. The aim of this study was to determine the effect of electromagnetic microwave radiation in stimulating thermal conditions in anaerobic reactors, on the effectiveness of methane fermentation process of microalgae biomass and on the qualitative composition of biogas produced. The quantity of gaseous metabolites of anaerobic bacteria produced in both experimental variants (convective and microwave heating) averaged approximat’s 450 cm³ g⁻¹ VS. The electromagnetic microwave radiation proved to have an immediate impact on the improvement in the qualitative composition of biogas produced. The stimulation of thermal conditions using electric heaters resulted in a methane contetnt of 65% in biogas, whereas the use of microwaves assured ca. 69% in sewage gas.
The combined impact of microwave radiation and cold storage on Tribolium castaneum Herbst and Sitophilus oryzae L. adults either continuously or intermittently was evaluated. The insects were exposed to 2 450 MHz at power level of 100 W for exposure time 10 min, continuously and intermittently. In all experiments, the highest rate of mortality was achieved for exposure time 10 min intermittently and 72 h cold storage duration. Intermittent exposures were generally more effective in killing insects of both species compared with those of continuous irradiation. Combinations of microwave radiation and cold storage were found highly compatible and synergistic. The synergistic interaction indicates that microwave radiation can be used with cold storage for management of T. castaneum and S. oryzae adult developmental stage. This treatment could provide an effective and friendly environmental treatment technique in Integrated Pest Management (IPM) program.
Corn and potato starches were physically modified by heating at 130 and 200°C or microwaving. On a basis of the results obtained it was found that upon heating or microwaving the content of amylose decreased and the reduction capacity increased for most of the modified starch preparations and all the preparations had an increased swelling capacity and water solubility. The greatest changes were observed for the preparations heated at 200°C, irrespective of starch. Microwave radiation caused slighlty smaller changes in the properties of starches. In the case of the preparations from potato starch it was observed a considerable increase in specific surface area of granules, an increase in volume of mesopores, and a decrease in their average diameter. The changes in these values were small in the preparations from corn starch.
W pracy zbadano plonowanie roślin czterech bardzo wczesnych odmian ziemniaka w zależności od wielkości zastosowanej dawki promieniowania mikrofalowego. Czynnikami doświadczenia były: odmiana ziemniaka (Felka Bona, Rosara, Velox i Lord), czas napromieniowania mikrofalami (5, 10 i 15 s) oraz moc generatora mikrofal (100, 200 i 300 W). Dawka promieniowania, moce generatora oraz czas napromieniania sadzeniaka mikrofalami istotnie modyfikowały plon bulw ziemniaka spod jednej rośliny. Napromienianie sadzeniaków mikrofalami pochodzącymi z generatora działającego z mocą 100 W przez czas 5-15 s powodowało, w odniesieniu do próby kontrolnej, zwiększenie plonu bulw ziemniaka spod jednej rośliny potomnej.
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