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Analysis of microsatellite instability and loss of heterozygosity in breast cancer with the use of a well characterized multiplex system

100%

Powierska-Czarny J., Miscicka-Sliwka D., Czarny J., Grzybowski T., Wozniak M., Drewa G., Czechowicz W., Sir J.

Acta Biochimica Polonica

2003

tom 50

nr 4

Analysis of microsatellite instability (MI) and loss of heterozygosity (LOH) is recommended for screening patients with sporadic and hereditary malignancies. This study shows an application of a fluorescent hexaplex PCR system for microsatellite typing on A.L.F. DNA Sequencer (Pharmacia Biotech). This technique detects changes in microsatellites providing a time-efficient, reliable and accurate method for MI and LOH analyses. The Fragment Manager software was used for automated size calculation and quantitation of DNA fragments, enabling rapid and precise measurement of allelic ratios. We examined 70 breast cancer and 70 control DNA specimens, classified all the patterns of microsatellite alterations, and set up MI and LOH assessment criteria for the automated multiplex fluorescent method.

Niestabilnosc mikrosatelitarna jako marker w badaniach wplywu skladnikow diety na powstawanie nowotworow

51%

Bobrowska B., Tokarz A., Kaminska M.

Bromatologia i Chemia Toksykologiczna

2010

tom 43

nr 3

323-329

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Bromatologia i Chemia Toksykologiczna

1 Bobrowska B.

1 Czarny J.

1 Czechowicz W.

1 Drewa G.

1 Grzybowski T.

1 Kaminska M.

1 Miscicka-Sliwka D.

1 Powierska-Czarny J.

1 Sir J.

1 Tokarz A.

1 Wozniak M.

1 2010

1 2003

Wyniki wyszukiwania

Analysis of microsatellite instability and loss of heterozygosity in breast cancer with the use of a well characterized multiplex system

Niestabilnosc mikrosatelitarna jako marker w badaniach wplywu skladnikow diety na powstawanie nowotworow