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1

The modulatory effect of aminothiols on the clastogenic activity of X-rays assayed by the in vivo mouse micronucleus test

100%
Mazur L.
Folia Biologica
|
1996
|
tom 44
|
nr 1-2
2

Genotoxicity of pyrethroids. Part 2. Studies on mutagenic activity of commercial formulations in mouse micronucleus test

84%
Chruscielska K., Kalhorn D.
Pestycydy
|
1999
|
nr 4
3

Aktywnosc mutagenna aminofenazyn

67%
Chruscielska K., Graffstein B., Szarapinska J., Heinrich R.
Acta Poloniae Toxicologica
|
1994
|
tom 02
|
nr 1
63-68
4

DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests

67%
Palyvoda O., Polanska J., Wygoda A., Rzeszowska-Wolny J.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 1
A population study is reported in which the DNA damage induced by y-radiation (2 Gy) and the kinetics of the subsequent repair were estimated by the comet and micronucleus assays in isolated lymphocytes of 82 healthy donors and patients with head and neck cancer before radiotherapy. The parameters of background and radia­tion-induced DNA damage, rate of repair, and residual non-repaired damage were measured by comet assay, and the repair kinetics for every donor were com­puter-fitted to an exponential curve. The level of background DNA damage before ir­radiation measured by comet assay as well as the level of micronuclei were signifi­cantly higher in the head and neck cancer patient group than in the healthy donors, while the parameters of repair were widely scattered in both groups. Cancer patient group contained significantly more individuals, whose irradiated lymphocytes showed high DNA damage, low repair rate and high non-repaired DNA damage level. Lymphocytes of donors belonging to this subgroup showed significantly lower inhibi­tion of cell cycle after irradiation.
5

Interferon alpha reduces the level of radiation-induced micronuclei in mouse bone marrow cells

67%
Fomenko L., Sirota N., Ravin V., Gaziev A.
Archivum Immunologiae et Therapiae Experimentalis
|
1997
|
tom 45
|
nr 5-6
6

Glyphosate. Evaluation of chronic activity and possible far - reaching effects. Part 2. Studies on mutagenic activity

67%
Chruscielska K., Graffstein B., Szarapinska-Kwaszewska J., Brzezinski J., Kalhorn D.
Pestycydy
|
2000
|
nr 3-4
7

DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test

59%
Brozovic G., Orsolic N., Rozgaj R., Kasuba V., Knezevic F., Knezevic A. H., Benkovic V., Lisicic D., Borojevic N., Dikic D.
Journal of Applied Genetics
|
2010
|
tom 51
|
nr 1
79-86
The relationship between DNA damage and repair of peripheral blood leukocytes, liver, kidney and brain cells was investigated in Swiss albino mice (Mas musculus L.) after exposure to sevoflurane (2.4 vol% for 2 h daily, for 3 days). Genetic damage of mouse cells was investigated by the comet assay and micronucleus test. To perform the comet assay, mice were divided into a control group and 4 groups of exposed mice sacrificed on day 3 of the experiment, at 0,2,6 or 24 h after the last exposure to sevoflurane. Mean tail length (TL), tail moment (TM), and tail intensity (TI) values were significantly higher in exposed mice (all examined organs) than in the control group. Significant DNA damage immediately after exposure to sevoflurane was observed in leukocytes. Damage induction in the liver, kidney, and brain occurred 6 h later than in leukocytes, as expected according to the toxicokinetics of the drug, where blood is the first compartment to absorb sevoflurane. However, none of the tested tissues revealed signs of repair until 24 h after the exposure. To distinguish the unrepaired genome damage in vivo, the micronucleus test was applied. Number of micronuclei in reticulocytes showed a statistically significant increase, as compared with the control group at all observed times after the treatment.
8

Micronucleus test and isozyme profile in the serum of sheep reard in the emission-polluted environment

59%
Buleca J., Piesova E., Mattova J., Szarek J., Ormian M.
Acta Agraria et Silvestria. Series Zootechnica
|
1999
|
tom 37
41-47
9

Ocena wlasciwosci genotoksycznych wybranych herbicydow i regulatorow wzrostu roslin w testach in vivo i in vitro

51%
Chruscielska K., Sitowska B., Graffstein B.
Bromatologia i Chemia Toksykologiczna
|
1998
|
tom 31
|
nr 3
265-272
Zbadano aktywność mutagenną wybranych formulacji herbicydów i regulatorów wzrostu oraz ich substancji biologicznie czynnych. Do oceny zastosowano model mutacji mitochondrialnych u Saccharomyces cerevisiae, mutacji barwnikowych u Chlorella vulgaris oraz test mikrojądrowy w komórkach szpiku kostnego myszy.
10

Badanie aktywnosci mutagennej fungicydow ditiokarbaminowych

43%
Chruscielska K., Pluciennik H., Kalhorn D., Graffstein B.
Acta Poloniae Toxicologica
|
1994
|
tom 02
|
nr 2
123-129
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