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1

Preliminary characterization of S-adenosylmethionine: tocopherol methyltransferase from chloroplasts of Calendula officinalis seedlings

100%
Michalowski M., Janiszowska W.
Acta Biochimica Polonica
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1993
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tom 40
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nr 1
2

Ergosterol biosynthesis inhibition: a target for antifungal agents

100%
Barrett-Bee K., Dixon G.
Acta Biochimica Polonica
|
1995
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tom 42
|
nr 4
The isoprenoid sterols play a crucial role in the viability of all fungi; those unable to synthesise ergosterol because of inhibition, growth conditions or mutation must take it up from the environment. A range of compound types have been discovered which interfere with the biosynthetic pathway from acetate to ergosterol and these compounds have antifungal actions. Inhibition of several of the steps has yielded agents which have been used with great success as medical and agrochemical agents. The most important biosynthetic steps that have been exploited are inhibition of squalene epoxidase, (the allylamines and tolnaftate) C14 demethylation (the azoles), A7,8 isomerase and A14 reductase which are inhibited by the morpholines. Recent research has shown that inhibition of C24 methyltransferase and C4 demethylation also yield antifungal agents. Combination studies demonstrate that synergy between agents of different types can be measured. Fungicidal effects were observed when a combination of two fungistatic agents was used.
3

Understanding the evolution of restriction-modification systems: Clues from sequence and structure comparisons

100%
Bujnicki J. M.
Acta Biochimica Polonica
|
2001
|
tom 48
|
nr 4
Restriction-modification (RM) systems comprise two opposing enzymatic activities: a restriction endonuclease, that targets specific DNA sequences and performs endonucleolytic cleavage, and a modification methyltransferase that renders these se­quences resistant to cleavage. Studies on molecular genetics and biochemistry of RM systems have been carried out over the past four decades, laying foundations for mod­ern molecular biology and providing important models for mechanisms of highly spe­cific protein-DNA interactions. Although the number of known, relevant sequences 3D structures of RM proteins is growing steadily, we do not fully understand their functional diversities from an evolutionary perspective and we are not yet able to en­gineer new sequence specificities based on rational approaches. Recent findings on the evolution of RM systems and on their structures and mechanisms of action have led to a picture in which conserved modules with defined function are shared between different RM proteins and other enzymes involved in nucleic acid biochemistry. On the other hand, it has been realized that some of the modules have been replaced in the evolution by unrelated domains exerting similar function. The aim of this review is to give a survey on the recent progress in the field of structural phylogeny of RM en­zymes with special emphasis on studies of sequence-structure-function relationships and emerging potential applications in biotechnology.
4
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TSD1 (TUMORUS SHOOT DEVELOPMENT1) and TSD2 genes related with cell wall function are involved in somatic embryogenesis induced in vitro in Arabidopsis

84%
Kudelko K., Grzybkowska D., Gaj M. D.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2013
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tom 94
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nr 3
5

Sequence analysis and structure prediction of aminoglycoside-resistance 16S rRNA:m7G methyltransferases

84%
Bujnicki J. M., Rychlewski L.
Acta Microbiologica Polonica
|
2001
|
tom 50
|
nr 1
6

The role of mammalian DNA methyltransferases in the regulation of gene expression

84%
Turek-Plewa J., Jagodzinski P. P.
Cellular and Molecular Biology Letters
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2005
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tom 10
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nr 4
7

Cloning of enterohemorrhagic Escherichia coli phage VT-2 Dam methyltransferase

84%
Radlinska M., Bujnicki J. M.
Acta Microbiologica Polonica
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2001
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tom 50
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nr 2
8

Site-directed mutagenesis defines the catalytic aspartate in the active site of the atypical DNA: m4C methyltransferase M.NgoMXV

84%
Radlinska M., Bujnicki J. M.
Acta Microbiologica Polonica
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2001
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tom 50
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nr 2
9

Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus

84%
Januchowski R., Prokop J., Jagodzinski P. P.
Journal of Applied Genetics
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2004
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tom 45
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nr 2
10

Sequence, structural, and evolutionary analysis of prokaryotic ribosomal protein L11 methyltransferases

67%
Bujnicki J. M.
Acta Microbiologica Polonica
|
2000
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tom 49
|
nr 1
11

DNA methyltransferases of Neisseria gonorrhoeae

67%
Piekarowicz A.
Acta Microbiologica Polonica
|
1994
|
tom 43
|
nr 3-4
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