Wyniki wyszukiwania

1

Formaline-induced fluorescence [FIF] as an auxiliary tool for the histopathological diagnosis of human cutaneous melanoma

100%

Sypniewska N., Barcikowska E., Chwirot B. W.

Cellular and Molecular Biology Letters

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2002

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tom 07

|

nr Suppl.

2

Flow cytometric estimation of the plasma membrane diversity of transplantable melanomas, using annexin V

88%

Cichorek M., Kozlowska K., Witkowski J. M., Zarzeczna M.

Folia Histochemica et Cytobiologica

|

2000

|

tom 38

|

nr 1

3

A receptor-type protein tyrosine phosphatase PTPsigma is expressed in human cutaneous melanomas

88%

Goldmann T., Otto F., Vollmer E.

Folia Histochemica et Cytobiologica

|

2000

|

tom 38

|

nr 1

4

Diversity of the plasma membrane properties of transplantable hamster melanomas with regard to the expression of P-glycoprotein

88%

Kozlowska K., Witkowski J. M., Zarzeczna M., Cichorek M.

Folia Histochemica et Cytobiologica

|

1999

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tom 37

|

nr 3

5

The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells

75%

Galanty A., Michalik M., Sedek L., Podolak I.

Cellular and Molecular Biology Letters

|

2008

|

tom 13

|

nr 4

585-598

We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both cell types in a time-and dose-dependent manner, and proved cytotoxic against cancer cells at significantly lower concentrations than for fibroblasts. LTS-4 also affected the morphology of the examined cells, causing vacuolisation and actin cytoskeleton disintegration, and had an inhibitory effect on the tumour cell motility.

6

Analysis of T cell receptor alpha beta variability in tumor-infiltrating lymphocytes in primary and metastatic melanoma

75%

Zeuthen J., Birck A., Straten P. T.

Archivum Immunologiae et Therapiae Experimentalis

|

1995

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tom 43

|

nr 2

7

Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth

75%

Cichorek M., Kozlowska K., Wachulska M., Zielinska K.

Folia Histochemica et Cytobiologica

|

2006

|

tom 44

|

nr 1

8

Oncogene-targeted antisense oligodeoxynucleotides combined with chemotherapy or immunotherapy: A new approach for tumor treatment?

75%

Nieborowska-Skorska M., Nakashima M., Ratajczak M., Steplewski Z., Calabretta B., Skorski T.

Folia Histochemica et Cytobiologica

|

1994

|

tom 32

|

nr 1

9

Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma

75%

Drzewiecka A., Urbanska K., Matuszak Z., Pineiro M., Arnaut L. G., Habdas J., Ratuszna A., Stochel G.

Acta Biochimica Polonica

|

2001

|

tom 48

|

nr 1

We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (us. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.

10

The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470

75%

Okroj M., Stawikowska D., Slominska E. M., Mysliwski A., Bigda J.

Cellular and Molecular Biology Letters

|

2006

|

tom 11

|

nr 3

TNP-470 is an acknowledged anti-angiogenic factor, and was studied clinically as an anti-cancer drug. We previously reported on an additional property of this molecule: the intracellular generation of reactive oxygen species in B16F10 melanoma cells. We showed that a massive generation of ROS occurred in the first few hours after treatment with TNP-470 and that this event was critical to subsequent cell death. In this study, we analyzed the process of cell death and noticed an atypical pattern of death markers. Some of these, such as DNA fragmentation or condensation of chromatin, were characteristic for programmed cell death, while others (the lack of phosphatidylserine flip-flop but permeability to propidium iodide, the maintenance of adhesion to the substratum, no change in mitochondrial transmembrane potential, no effect of the panspecific caspase inhibitor) rather suggested a necrotic outcome. We concluded that TNP-470 induced at least some pathways of programmed cell death. However, increasing damage to critical cell functions appears to cause a rapid switch into the necrotic mode. Our data is similar to that in other reports describing the action of ROS-generating agents. We hypothesize that this rapid programmed cell death/necrosis switch is a common scenario following free radical stress.

11

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Iris melanoma in a Labrador retriever

63%

Kanemaki N.

Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii

|

2012

|

nr 1

U psów stosunkowo często spotykamy w gałce ocznej czerniaki. W przeciwieństwie do czerniaków występujących u kotów, u psów rzadko dają one przerzuty. Wczesne wykrycie tego typu zmian w oku zapobiega dalszym komplikacjom. Praca ta przedstawia przypadek czerniaka tęczówki u psa rasy labrador retriever. Początkowo zmianę tęczówki leczono steroidami i antybiotykami. Lecz leczenie to nie przyniosło oczekiwanych rezultatów. Dalsze diagnozowanie (ultrasonografia, gonioskopia) wykazało, że jest to czerniak. Wykonano resekcję części tęczówki. Siedem tygodni po resekcji zmiany, powrócił odruch źreniczny i widzenie. Badanie histopatologiczne wykazało, że usunięta zmiana to melanocytoma.

12

Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells

63%

Budlak R. J., Polaniak R., Buldak L., Mielanczyk L., Kukla M., Skonieczna M., Dulawa-Buldak A., Matysiak N., Zwirska-Korczala K.

Journal of Physiology and Pharmacology

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2013

|

tom 64

|

nr 3

13

Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features

63%

Alekseenko A., Wojas-Pelc A., Lis G. J., Wisniowski Z., Czerwinska M., Niewiara L., Litwin J. A.

Folia Histochemica et Cytobiologica

|

2012

|

tom 50

|

nr 2

14

Anti-cancer effect of betulin and its derivatives, with particular emphasis on the treatment of melanoma

63%

Cabaj J., Bak W., Wroblewska-Luczka P.

Journal of Pre-Clinical and Clinical Research

|

2021

|

tom 15

|

nr 2

15

Iris melanoma in a Labrador Retriever

63%

Kanemaki N.

Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii

|

2013

|

nr 1

U psów stosunkowo często spotykamy w gałce ocznej czerniaki. W przeciwieństwie do czerniaków występujących u kotów, u psów rzadko dają one przerzuty. Wczesne wykrycie tego typu zmian w oku zapobiega dalszym komplikacjom. Praca ta przedstawia przypadek czerniaka tęczówki u psa rasy labrador retriever. Początkowo zmianę tęczówki leczono steroidami i antybiotykami. Lecz leczenie to nie przyniosło oczekiwanych rezultatów. Dalsze diagnozowanie (ultrasonografia, gonioskopia) wykazało, że jest to czerniak. Wykonano resekcję części tęczówki. Siedem tygodni po resekcji zmiany, powrócił odruch źreniczny i widzenie. Badanie histopatologiczne wykazało, że usunięta zmiana to melanocytoma.

16

Rebalancing immune specificity and function in cancer by T-cell receptor gene therapy

63%

Udyavar A., Geiger T. L.

Archivum Immunologiae et Therapiae Experimentalis

|

2010

|

tom 58

|

nr 5

335-346

17

Melanoma and skin cancers in psoriatic patients treated with phototherapy. Role of the p16 protein in psoriasis

63%

Szponar-Bojda A., Pietrzak A., Sobczynska-Tomaszewska A., Borzecki A., Kurylcio A., Polkowski W., Poluha A., Chodorowska G.

Folia Histochemica et Cytobiologica

|

2012

|

tom 50

|

nr 4

18

Pre-operative levels of serum immunoglobulins, circulating immune complexes and complement proteins in patients with different types of neoplasms

63%

Gendek-Kubiak H., Grzegorczyk J., Gendek E. G., Kowalski M. L., Berner J.

Archivum Immunologiae et Therapiae Experimentalis. Supplement

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2001

|

tom 49

|

nr 2

89-95

19

Expression of beta1-integrins and N-cadherin in bladder cancer and melanoma cell lines

63%

Laidler P., Gil D., Pituch-Noworolska A., Ciolczyk D., Ksiazek D., Przybylo M., Litynska A.

Acta Biochimica Polonica

|

2000

|

tom 47

|

nr 4

Changes in the expression of integrins and cadherins might contribute to the progression, invasion and metastasis of transitional cell cancer of the bladder and of melanomas. The expression of alpha5 (P<0.001), alpha2 and beta1 (P<0.05-P<0.001) integrin subunits in melanoma cells from noncutaneous metastatic sites (WM9, A375) were significantly increased as compared to cutaneous primary tumor (WM35) and metastatic (WM239) cell lines. These differences might be ascribed to the invasive character of melanoma cells and their metastasis to the noncutaneous locations. The significantly heterogeneous expression of beta1 integrin subunit in two malignant bladder cancer cell lines (T24 and Hu456) and nonsignificant differences in the expression of alpha2, alpha3, and alpha5 subunits between malignant and non-malignant human bladder cell lines do not allow an unanimous conclusion on the role of these intergrin subunits in the progression of transitional cancer of bladder. The adhesion molecule, expressed in all studied melanoma and bladder cell lines, that reacted with anti-Pan cadherin monoclonal antibodies was identified as N-cadherin except in the HCV29 non-malignant ureter cell line. However, neither this nor any other bladder or melanoma cell line expressed E-cadherin. The obtained results imply that the replacement of E-cadherin by N-cadherin accompanied by a simultaneous increase in expression of alpha2, alpha3 and alpha5 integrin subunits clearly indicates an increase of invasiveness of melanoma and, to a lesser extent, of transitional cell cancer of bladder. High expression of N-cadherin and alpha5 integrin subunit seems to be associated with the most invasive melanoma phenotype.

20

Combination of vasostatin and cyclophosphamide in the therapy of murine melanoma tumors

63%

Jazowiecka-Rakus J., Jarosz M., Kozlowska D., Sochanik A., Szala S.

Acta Biochimica Polonica

|

2007

|

tom 54

|

nr 1

Growth of tumors is strongly dependent upon supply of nutrients and oxygen by de novo formed blood vessels. Inhibiting angiogenesis suppresses growth of primary tumors as well and affects development of metastases. We demonstrate that recombinant MBP/vasostatin fusion protein inhibits proliferation of endothelial cells in vitro. The therapeutic usefulness of such intratumorally delivered recombinant protein was then assessed by investigating its ability to inhibit growth of experimental murine melanomas. In the model of B16-F10 melanoma the MBP/vasostatin construct significantly delayed tumor growth and prolonged survival of treated mice. A combination therapy involving MBP/vasostatin construct and cyclophosphamide was even more effective and led to further inhibition of the tumor growth and extended survival. We show that such combination might be useful in the clinical setting, especially to treat tumors which have already formed microvessel networks.

Ograniczanie wyników

Formaline-induced fluorescence [FIF] as an auxiliary tool for the histopathological diagnosis of human cutaneous melanoma

Flow cytometric estimation of the plasma membrane diversity of transplantable melanomas, using annexin V

A receptor-type protein tyrosine phosphatase PTPsigma is expressed in human cutaneous melanomas

Diversity of the plasma membrane properties of transplantable hamster melanomas with regard to the expression of P-glycoprotein

The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells

Analysis of T cell receptor alpha beta variability in tumor-infiltrating lymphocytes in primary and metastatic melanoma

Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth

Oncogene-targeted antisense oligodeoxynucleotides combined with chemotherapy or immunotherapy: A new approach for tumor treatment?

Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma

The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470

Iris melanoma in a Labrador retriever

Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells

Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features

Anti-cancer effect of betulin and its derivatives, with particular emphasis on the treatment of melanoma