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1

Lymphangioinvasion in routine H and E staining is strongly associated with poor clinical outcome in lymph node-negative cutaneous melanoma patients

100%
Donizy P., Kaczorowski M., Halon A., Leskiewicz M., Matkowski R.
Folia Histochemica et Cytobiologica
|
2016
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tom 54
|
nr 3
2

How in began

100%
Cummins J. M., Georgiades J. A.
Archivum Immunologiae et Therapiae Experimentalis
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1993
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tom 41
|
nr 3-4
3
Content available remote

Exogenous administration of visfatin affects cytokine secretion and increases oxidative stress in human malignant melanoma Me45 cells

84%
Budlak R. J., Polaniak R., Buldak L., Mielanczyk L., Kukla M., Skonieczna M., Dulawa-Buldak A., Matysiak N., Zwirska-Korczala K.
Journal of Physiology and Pharmacology
|
2013
|
tom 64
|
nr 3
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Molecular and environmental aspects of skin cancers

84%
Zebracka A., Matysiak M., Dudra-Jastrzebska M., Kapka-Skrzypczak L.
Journal of Pre-Clinical and Clinical Research
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2015
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tom 09
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nr 2
Skin cancers are one of the most common cancers in the Caucasian population. A constantly increasing number of nonmelanoma skin cancers and malignant melanomas is observed. The incidence of skin cancers is associated mainly with exposure to sunlight. Therefore, agricultural workers who work in open spaces are a particularly vulnerable group. Currently, studies on the pathogenesis of skin cancer focus on the molecular basis associated with ultraviolet radiation. This study is an attempt to summarize the current state of knowledge on this issue. There have been demonstrated mutations in different classes of genes associated with carcinogenesis, including protooncogenes, tumour suppressor genes, genes that control apoptosis, genes encoding transcription factors and DNA repair genes in patients with skin cancers. Mutations in the latter result in reducing the effectiveness of DNA repair and fixation of mutations. All changes at the gene level lead to structural changes, quantitative and dysfunction of proteins encoded by these genes. All these factors contribute to the process of carcinogenesis. Due to increasing number of skin cancers, it seems important to increase knowledge of the molecular basis of skin cancers. This knowledge could be crucial for predicting the course of the disease, and for the development of new therapeutic strategies.
5

Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features

84%
Alekseenko A., Wojas-Pelc A., Lis G. J., Wisniowski Z., Czerwinska M., Niewiara L., Litwin J. A.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 2
6

Expression of P53 protein in primary uveal melanoma

84%
Sulkowski S., Sulkowska M., Famulski W., Chyczewski L., Bakunowicz-Lazarczyk A.
Folia Histochemica et Cytobiologica
|
2001
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tom 39
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nr 2
7

The effect of chemo- and chemoimmunotherapy on the presence of circulating melanoma cells in peripheral blood. Preliminary results

84%
Szenajch J., Kozak A., Kruszewski A. A., Babiej E., Chomicka M., Struzyna J., Wiktor-Jedrzejczak W.
Acta Biochimica Polonica
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1998
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tom 45
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nr 1
Reverse transcription and polymerase chain reaction (RT/PCR) with primers specific for tyrosinase allow for a new method of early detection of individual melanoma cells in peripheral blood. Using this test the effect of chemo- and chemoimmunotherapy on the spread of early micrometastatic cancer cells has been evaluated. No significant correlations have been found between RT/PCR results on the one hand and stage of disease, a kind of the therapy protocol used and usage of the therapy as an adjuvant or palliative on the other hand. Thus, although the RT/PCR test for detection of circulating individual melanoma cells might help in identification of minimal residual disease in some patients, it has no application for routine staging of more advanced disease and in monitoring the response to therapy.
8

Recent discoveries in the genetics of malanoma and their therapeutic implications

84%
Marquette A., Bagot M., Bensussan A., Dumaz N.
Archivum Immunologiae et Therapiae Experimentalis
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2007
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tom 55
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nr 6
9

Epidemiological analysis of cutaneous malignant melanoma incidence in the population of Upper Silesia

67%
Juszko-Piekut M., Kolosza Z., Mozdzierz A.
Polish Journal of Environmental Studies
|
2004
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tom 13
|
nr Suppl.2, Part 1
The effects of unemployment also include consequences for health that are experienced by the unemployed themselves and by their families and in a broader social scale. The aim of the study was to evaluate the influence of unemployment on the health condition of the unemployed in the Lublin Region. The study was carried out in 2000-2003 and included 1560 subjects that were the unemployed registered in the Municipal and Provincial Labour Offices in Lublin, Świdnik, Lubartów, Puławy and Kraśnik. The research tool was a questionnaire survey and the research method was a diagnostic sounding.
10

Evaluation of melanogenesis in A-375 melanoma cells treated with 5,7-dimethoxycoumarin and valproic acid

67%
Chodurek E., Orchel A., Orchel J., Kurkiewicz S., Gawlik N., Dzierzewicz Z., Stepien K.
Cellular and Molecular Biology Letters
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2012
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tom 17
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nr 4
Malignant melanoma (melanoma malignum) is one of the most dangerous types of tumor. It is very difficult to cure. In recent years, a lot of attention has been given to chemoprevention. This method uses natural and synthetic compounds to interfere with and inhibit the process of carcinogenesis. In this study, a new treatment strategy was proposed consisting of a combination of 5,7-dimethoxycoumarin (DMC), an activator of melanogenesis, and valproic acid (VPA), a well-known drug that is one of the histone deacetylase inhibitors (HDACis). In conjunction with 1 mM VPA, all of the tested concentrations of DMC (10–150 μM) significantly decreased the proliferation of A-375 cells. VPA and DMC also induced the synthesis of melanin and the formation of dendrite and star-shaped cells. Tyrosinase gene expression and tyrosinase activity significantly increased in response to VPA treatment. Pyrolysis with gas chromatography and mass spectrometry (Py-GC/MS) was used to investigate the structure of the isolated melanin. This showed that the quantitative and qualitative components of melanin degradation products are dependent on the type of applied melanogenesis inductor. Products derived from eumelanin were detected in the pyrolytic profile of melanin isolated from A-375 cells stimulated with DMC. Thermal degradation of melanin isolated from melanoma cells after exposure to VPA or a mixture of VPA and DMC revealed the additional presence of products derived from pheomelanin.
11

Photodynamic effects of two water soluble porphyrins evaluated on human malignant melanoma cells in vitro

67%
Szurko A., Kramer-Marek G., Widel M., Ratuszna A., Habdas J., Kus P.
Acta Biochimica Polonica
|
2003
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tom 50
|
nr 4
Two water soluble porphyrins: meso-tetra-4-N-methylpyridyl-porphyrin iodide (P1) and 5,10-di-(4-acetamidophenyl)-15,20-di-(4-N-methylpyridyl) porphyrin (P2) were synthesised and evaluated in respect to their photochemical and photophysical properties as well as biological activity. Cytotoxic and phototoxic effects were evaluated in human malignant melanoma Me45 line using clonogenic assay, cytological study of micronuclei, apoptosis and necrosis frequency and inhibition of growth of megacolonies. Both porphyrins were characterised by high UV and low visible light absorptions. Dark toxicity measured on the basis of the clonogenic assay and inhibition of megacolony growth area indicated that P1 was non-toxic at concentrations up to 50 ug/ml (42.14 uM) and P2 at concentrations up to 20 ug/ml (16.86 uM). The photodynamic effect induced by red light above 630 nm indicated that both porphyrins were able to inhibit growth of melanoma megacolonies at non-toxic concentrations. Cytologic examination showed that the predominant mode of cell death was necrosis.
12

Podstawy stomatologii weterynaryjnej. Cz. XIV. Złośliwe zmiany w jamie ustnej

51%
Bellows J.
Weterynaria po Dyplomie
|
2019
|
tom 20
|
nr 6
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