Wyniki wyszukiwania

1

Antibiotic therapy and fat digestion and absorption in cystic fibrosis

100%

Lisowska A., Pogorzelski A., Oracz G., Skorupa W., Cofta S., Szydlowski J., Socha J., Walkowiak J.

Acta Biochimica Polonica

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2011

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tom 58

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nr 3

Antibiotic therapy in the cystic fibrosis (CF) mouse model has been shown to result in reduced bacterial load of the intestine and significant body mass gain. The effect was suggested to be linked to the improvement of intestinal digestion and absorption. Therefore, we aimed to assess the influence of routinely applied antibiotic therapy in CF patients on fat assimilation. Twenty-four CF patients aged 6 to 30 years entered the study. Inclusion criteria comprised confirmed exocrine pancreatic insufficiency and bronchopulmonary exacerbation demanding antibiotic therapy. Exclusion criteria comprised: antibiotic therapy six weeks prior to the test, liver cirrhosis, diabetes mellitus, oxygen dependency, the use of systemic corticosteroids. In all enrolled CF subjects, 13C-labelled mixed triglyceride breath test (13C MTG-BT) was performed to assess lipid digestion and absorption, before and after antibiotic therapy. Sixteen subjects were treated intravenously with ceftazidime and amikacin, eight patients orally with ciprofloxacin. Cumulative percentage dose recovery (CPDR) was considered to reflect digestion and absorption of lipids. The values are expressed as means (medians). The values of CPDR before and after antibiotic therapy did not differ in the whole studied group [4.6(3.3) % vs. 5.7(5.3) %, p = 0.100] as well as in the subgroup receiving them intravenously [4.6(3.2) % vs. 5.7(5.3) %, p = 0.327] or in that with oral drug administration [4.6(3.4) % vs. 5.7(5.4) %, p = 0.167]. In conclusion, antibiotic therapy applied routinely in the course of pulmonary exacerbation in CF patients does not seem to result in an improvement of fat digestion and absorption.

2

The progress in bariatric surgery

100%

Pardela M., Wiewiora M., Sitkiewicz T., Wylezol M.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 6

35-44

Morbid obesity, caused by fat tissue accumulation, is a serious multi-factorial chronic disease, with rapidly increasing prevalence in most countries in the world including Poland. Conservative treatment of morbid obesity is almost always unsatisfactory and that is why several surgical methods have been developed. There are four kinds of methods: malabsorptive procedures; restrictive procedures; malabsorptive/restrictive procedures and experimental procedures. The development of bariatric surgery goes back to 1952 and since that time it has been evolving dynamically. All the surgical methods have benefits and disadvantages. Presently the introduction of minimally invasive surgical techniques seems to be very safe, efficient and cost-effective in treatment for morbid obesity. New methods are also being evaluated, such as gastric myo-electrical stimulation. Bariatric surgery will still be developing until we understand all the factors responsible for it is origin.

3

The usefulness of D-xylose and glucose intestinal absorption tests in the evaluation of the intestinal absorption in dogs

84%

Nieradka R.

Polish Journal of Veterinary Sciences

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1999

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tom 02

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nr 1

The investigation was carried out on 40 dogs of different sex, age and breed. The animals were divided into 3 groups: I (control) – 20 healthy dogs, II - dogs with diarrhoea aged under 1.5 years, III - dogs with Falimentary tract catarrh symptoms aged over 1.5 years. Clinicaf examinations were performed in all the animals. In 5 randomly chosen dogs from each group, D-xylose and glucose loading tests were performed. The results of D-xylose and glucose tests in the dogs of group I were found to be normal. In the dogs of group II, the results of both tests were lower than normal, and in the dogs of group III they were comparable with those found in the control group. The results of the present study suggest that the D-xylose and glucose loading tests are reliable for determining the intestinal absorption efficiency. D-xylose test can be substituted with a glucose loading test which gives comparable results.

4

Interakcje pomiedzy zywnoscia a lekami - wazny problem w praktyce lekarskiej

67%

Jarosz M., Dzieniszewski J., Ryzko-Skiba M.

Żywność Żywienie Prawo a Zdrowie

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2001

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tom 10

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nr 1

71-77

5

Selective cobalamin malabsorption and the cobalamin-intrinsic factor receptor

67%

Grasbeck R.

Acta Biochimica Polonica

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1997

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tom 44

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nr 4

The disease is characterised by cobalamin (Cbl) deficiency in children 0-5 years old, causing failure to thrive, infections, megaloblastic anaemia, neuropathy, and mild general malabsorption; slight proteinuria is common. Cbl injections produce remission, but Cbl malabsorption and proteinuria persist. About 250 cases have been reported. Dogs also have it. The heredity is autosomal and recessive. The physiological and pathological absorption mechanisms are described: Cbl liberated from food by digestion is first bound to haptocorrin, but in the intestine it is transferred to intrinsic factor. In the ileum the complex attaches to a receptor on the enterocytes; this requires neutral pH and Ca2+. The receptor is a membrane-bound glycoprotein consisting of multiple subunits. The receptor-ligand complex is endocytosed and degraded in lysosomes, and the vitamin is transferred to transcobalamin which carries it to tissues. The same receptor is strongly expressed in the kidneys, but urine also contains its activity which can be assayed for diagnosis. The basic lesion is an error in the ileal receptor. In the affected dogs the synthesised receptor is retained intracellularly. Urine and ileal biopsies from human cases contained little receptor but it had conserved affinity for the ligand. Recently examined Arab patients did not excrete reduced amounts of the receptor. Apparently, the disease has subsets, such as different structural errors in the receptor and possibly faulty transport inside the enterocyte. The cause of the proteinuria is unknown but kidney damage due to severe Cbl deficiency and an error in a multiligand renal receptor are among the possibilities.

6

Wplyw diety bezglutenowej na poziom wybranych makro- i mikroelementow we wlosach pacjentow z choroba trzewna

51%

Chelstowska M., Dorosz A., Lukasiak J.

Bromatologia i Chemia Toksykologiczna

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2005

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tom 38

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nr Supl.

515-519

Choroba trzewna jest chorobą jelita cienkiego o wieloczynnikowej etiologii. Istotą jej jest trwała nietolerancja glutenu, w wyniku której dochodzi do znacznego spłaszczenia kosmków jelitowych doprowadzającego do klinicznych i laboratoryjnych objawów zaburzeń trawienia i wchłaniania. U większości pacjentów wystarczającym leczeniem jest dieta bezglutenowa. Autorzy pracy postanowili sprawdzić, czy powyższa dieta wpływa korzystnie na poziom wybranych pierwiastków we włosach pacjentów z chorobą trzewną. Badania przeprowadzono u 34 dzieci z celiakią rozpoznaną co najmniej rok przed badaniem, w tym 12 płci męskiej i 22 płci żeńskiej oraz u 37 osób zdrowych, w tym 21 płci męskiej i 16 płci żeńskiej. Średni wiek badanych pacjentów wynosił 13.9lat (4 - 19lat) a grupy kontrolnej 10. Siat (2 - 19lat). Chorobę trzewną rozpoznano na podstawie badania histopatologicznego wycinka śluzówki proksymalnego odcinka jelita cienkiego oraz obecności przeciwciał przeciwko endomyzjum (IgAEmA). Materiał do badania uzyskano pobierając 1 - 3 cm odcinki włosów licząc od skóry głowy z 1 - 3 punktów. Pomiar wybranych mikroelementów wykonano metodą atomowej spektroskopii absorpcyjnej (w przypadku Mg, Ca, Zn, Fe) i emisyjnej ( w przypadku K) techniką płomieniową. Wynik poddano analizie statystycznej i stwierdzono, iż nie ma różnic istotnych statystycznie w zawartości Mg, Ca, Fe, K we włosach między grupą badaną a kontrolną. Natomiast różnica istotna statystycznie istnieje w zawartości Zn we włosach osób z chorobą trzewną w porównaniu z grupą kontrolną. Powyższe wyniki, z wyjątkiem Zn, są zgodne z wynikami innych badaczy, którzy obserwują obniżony poziom badanych mikroelementów w momencie rozpoznania choroby trzewnej i powrót do wartości prawidłowych w wyniku zastosowania diety bezglutenowej. Być może wpływ na powyższe wyniki ma regularne przyjmowanie preparatów wielowitaminowych z mikroelementami przez około 67% badanych dzieci z chorobą trzewną i tylko przez 15% dzieci z grupy kontrolnej.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Bromatologia i Chemia Toksykologiczna

1 Journal of Physiology and Pharmacology. Supplement

1 Polish Journal of Veterinary Sciences

1 Żywność Żywienie Prawo a Zdrowie

1 Chelstowska M.

1 Cofta S.

1 Dorosz A.

1 Dzieniszewski J.

1 Grasbeck R.

1 Jarosz M.

1 Lisowska A.

1 Lukasiak J.

1 Nieradka R.

1 Oracz G.

1 Pardela M.

1 Pogorzelski A.

1 Ryzko-Skiba M.

1 Sitkiewicz T.

1 Skorupa W.

1 Socha J.

1 Szydlowski J.

1 Walkowiak J.

1 Wiewiora M.

1 Wylezol M.

1 2011

2 2005

1 2001