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1
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Melatonin-induced glycosaminoglycans augmentation in myocardium remote to infarction

100%
Drobnik J., Tosik D., Piera L., Szczepanowska A., Olczak S., Zielinska A., Liberski P. P., Ciosek J.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 6
2
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Labeled [3H]-thymidine incorporation in the DNA of 3T3-L1 preadipocytes due to MT2- and not MT3- melatonin receptor

100%
Adamczyk-Sowa M., Sowa P., Zwirska-Korczala K., Pierzchala K.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 1
3
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Influence of melatonin on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3-L1 preadipocytes - an in vitro study

100%
Zwirska-Korczala K., Jochem J., Adamczyk-Sowa M., Sowa P., Polaniak R., Birkner E., Latocha M., Pilc K., Suchanek R.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 6
91-99
Melatonin, acting via MT1, MT2 and MT3 membrane receptors, influences central and peripheral regulatory mechanisms of energy homeostasis in mammals. In peripheral tissues, it evokes the pro-proliferative effect in a number of normal cells. Moreover, this hormone inhibits lipolysis in subcutaneous adipocytes in vitro and reduces free oxygen metabolites-induced damage acting directly, as a free radical scavenger, and indirectly, by stimulation of antioxidative enzyme activities. The aim of the study was to examine the effects of melatonin on cell proliferation, antioxidative enzyme activities and malondialdehyde (MDA) concentration in 3T3-L1 preadipocyte cell culture. We found that melatonin (10-3 and 10-6 M/L) stimulated cell proliferation in dose- and time-depending manner, and this effect was inhibited by a relatively selective MT2 receptor antagonist - luzindole (10-4 M/L). Melatonin, increased activities of manganese containing and copper-zinc containing superoxide dismutase (MnSOD and Cu/ZnSOD) isoenzymes, catalase, glutathione reductase and glutathione peroxidase after 24 h of incubation. In contrast, after 48 h of incubation, activities of all studied enzymes were lower than in the control group. There were no changes in MDA concentrations after 24 h of incubation, whereas, in melatonin-treated media, after 48 h of the experiment, MDA level was significantly decreased. Our results demonstrate that melatonin, acting via MT2 receptors, stimulates proliferation of 3T3-L1 preadipocytes and this action could be due to the enhancement in antioxidative enzyme activities and attenuation of lipid peroxidation by this indole.
4
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The influence of melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies

100%
Juszczak M., Roszczyk M., Kowalczyk E., Stempniak B.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 6
5
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Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat

100%
Jaworek J., Konturek S. J., Leja-Szpak A., Nawrot K., Bonior J., Tomaszewska R., Stachura J., Pawlik W. W.
Journal of Physiology and Pharmacology
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2002
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tom 53
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nr 4,2
The present study investigated the involvement of endogenous melatonin in the prevention of pancreatic damage provoked by caerulein-induced pancreatitis (CIP) by using the luzindole, the antagonist of melatonin MT2 receptors. CIP was produced by subcutaneous infusion of caerulein to conscious rats (25 µg/kg). Luzindole (1, 2 or 4 mg/kg) was given as an intraperitoneal bolus injection 30 min prior to the start of CIP. Lipid peroxidation products, malondialdehyde (MDA) and 4- hydroxynonenal (4-HNE) were measured in the pancreas by LPO-584 commercial kit. CIP was confirmed by histological examination and manifested by significant increases of plasma activities of amylase, lipase and tumor necrosis factor a (TNFalpha) (by 500%, 1000% and 600%, respectively) comparing to the control values. This was accompanied by a 40% limitation in pancreatic blood flow (PBF) and by 200% increase of MDA+4-HNE in the pancreas of CIP rats. Administration of luzindole to the CIP rats reduced PBF, aggravated the histological manifestations of pancreatitis, resulted in the significant augmentation of pancreatic MDA + 4-HNE content, and produced the marked increases of plasma levels of lipase, amylase and TNFalpha, comparing to the values observes in the rats with CIP alone. These results suggest that endogenous melatonin through its receptor MT2 plays an important role in the attenuation of pancreatic damage produced by overstimulation with caerulein.
6
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Central nervous stimuli increase duodenal bicarbonate secretion by release of mucosal melatonin

100%
Sjoblom M., Flemstrom G.
Journal of Physiology and Pharmacology
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2001
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tom 52
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nr 4,1
A number of common diseases in humans, including gastroduodenal ulcer and irritable bowel syndrome, show circadian rhythms in pain and discomfort. The neurohormone melatonin is released from enterochromaffin cells in the intestinal mucosa and from the pineal gland but its role in gastrointestinal function is largely unknown. We have studied the involvement of melatonin in stimulation of the mucosa-protective alkaline secretion by the duodenal mucosa. A 12-mm segment of proximal duodenum with an intact blood supply was cannulated in situ in anesthetized rats and duodenal HCO3– secretion titrated by pH-stat. Duodenal close intra-arterial infusion of melatonin or the full agonist 2-iodo-N-butanoyl- 5-methoxytryptamine significantly increased the secretion and pretreatment with the melatonin (predominantly MT2-receptor specific) antagonist luzindole almost abolished the response. Intracerebroventricular (i.c.v.) infusion of the alpha1-adrenoceptor agonist phenylephrine (12.2 µmol kg-1·h-1 ) caused an up to fivefold increased in the alkaline secretion and the melatonin antagonist luzindole or cutting all peri-carotid nerves abolished the duodenal secretory response to i.c.v. phenylephrine. Peripheral melatonin thus stimulates duodenal mucosal HCO3 – secretion and endogenous melatonin, very likely released from mucosal enterochromaffin cells, is involved in mediating neural stimulation of the secretion.
7
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Melatonin-induced protein synthesis in the rat parotid gland

80%
Cevik-Aras H., Godoy T., Ekstrom J.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 1
Melatonin occurs in large amounts in the intestinal mucosa and is released during a meal. Recent studies of ours reveal that exogenous melatonin evokes the in vivo secretion of protein and amylase from the rat parotid gland. The aim of the present study was to investigate the effect of melatonin on the protein synthesis of the parotid gland of pentobarbitone-anaesthetised rats as estimated by the rate of incorporation of [3H]leucine into trichloroacetic acid-insoluble material of the gland. Compared with the parotid protein synthesis (set at 100%) of those rats exposed to an intravenous infusion of melatonin (25 mg/kg during 1 hour), under muscarinic and - and ß-adrenoceptor blockade, the synthesis in the corresponding glands of saline-treated control rats was less (by 25%). The synthesis was also less when the melatonin administration was combined with the melatonin 2-preferring receptor antagonist luzindole (24%), the non-selective nitric oxide synthase inhibitor L-NAME (18%) and the neuronal nitric oxide synthase inhibitor N-PLA (21%). Almost all the melatonin receptor-mediated effect was due to nitric oxide generation via the activity of neuronal type nitric oxide synthase. The present findings lend further weight to the idea that salivary glandular activity associated with food intake is hormonally influenced and they also suggest clinical implications for melatonin in the treatment of xerostomia. Since melatonin is known to exert anti-inflammatory actions in the oral cavity, the stimulatory effect of melatonin may include the synthesis of proteins of importance for the oral defence.
8
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Mucosal strengthening activity of central and peripheral melatonin in the mechanism of gastric defense

80%
Brzozowska I., Ptak-Belowska A., Pawlik M., Bajdo R., Drozdowicz D., Konturek S. J., Pawlik W. W., Brzozowski T.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 7
9
Content available remote

Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-GABAergic mechanism

80%
Zurowski D., Nowak L., Machowska A., Wordliczek J., Thor P. J.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 6
10

Effect of central administration of L-tryptophan [melatonin precursor] and luzindole [melatonin MT2 receptor antagonist] on the course of caerulein induced acute pancreatitis in the rat

80%
Nawrot K., Jaworek J., Bonior J., Leja-Szpak A., Kot M., Sendur R., Pawlik W. W., Konturek S. J.
Journal of Physiology and Pharmacology. Supplement
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2001
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tom 52
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nr 2
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