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Prognostic risk factors in patients with interstitial lung disease referred for lung transplantation

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Jastrzebski D., Kozielski J., Nowak J., Zielinska-Les I., Ziora D., Szulik B., Wojarski J., Zakliczynski M., Zembala M.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 4
107-113
The aim of the study was to identify prognostic factors that would differentiate patients with interstitial lung disease between those with and without a chance to survive until lung transplantation. A retrospective study was performed in patients with interstitial lung disease referred for lung transplantation between September 1999 and April 2005. The analysis included the demographic data, the time from referral to transplantation, the functional tests (FVC, FEV1, FEV1%VC, the PaO2 at rest and after oxygen supplementation via a nasal catheter), the count of NYHA functional classes, the left ventricular ejection fraction (EF), the distance covered during a 6-min walk test, and the pathogens in the respiratory tract. The patients were divided into two groups: Group 1 - lung transplant candidates who survived until the successful procedure and Group 2 - lung transplant candidates who died while on the waiting list. There were statistical differences between the two groups in PaO2 after supplementation (P=0.005), EF (P=0.002), and the 6-min walk distance (P=0.001). It appears that simple functional tests of the cardiorespiratory system may define survival of patients with interstitial lung disease waiting for lung transplantation.
2
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Right ventricular function in patients with severe interstitial lung disease: a tissue Doppler imaging study

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Nowak J., Jastrzebski D., Streb W., Rozentryt P., Wojarski J., Greif M., Kozielski J., Polonski L., Zembala M., Kukulski T.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
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nr 6
531-538
3
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Current status of lung transplantation in Poland: experience of the Silesian Center for Heart Diseases

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Wojarski J., Jastrzebski D., Zembala M.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 4
245-249
Until the year 2001, lung transplantation was not available in Poland, as the only one among other kinds of solid organs transplantation. In 2001, in the Silesian Center for Heart Diseases the first successful combined heart-lung-one-block transplantation was performed. In 2003 and 2004, a successful single lung transplantation in Poland was performed in our center. Here the authors presented their experience with lung transplantation including the indications for specific types of transplantation, the immunosuppressive regimen, the management of early and late stages after lung transplantation, the infection complications, and the current problems with lung transplantation progress.
4
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Quality of life during one-year observation of patients with idiopathic pulmonary fibrosis awaiting lung transplantation

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Jastrzebski D., Kozielski J., Banas A., Cebula T., Gumola A., Ziora D., Krzywiecki A.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 4
99-105
The aim of the study was to evaluate the quality of life and its changes in patients with idiopathic pulmonary fibrosis (IPF), waiting for lung transplantation. Sixteen IPF patients, who qualified for lung transplantation, and 14 chronic obstructive pulmonary disease (COPD) patients on long term oxygen therapy, taken as a reference group, were assessed. The quality of life was estimated twice, using an SF-36-questionnaire, at the time of qualification for lung transplantation and 12 months later. The IPF and reference patients had similarly profound disturbances in lung function and arterial blood gas content. The IPF patients had a statistically greater score in their physical functioning (PF; 45 vs. 18), the role of limitations due to physical problems (RP; 43 vs. 11), social functioning (SF; 58 vs. 30), and the role of emotional limitations in everyday life (RE; 65 vs. 12) than the reference ones. After a year's observation, there were no differences in SF-36 questionnaire results, except for the role of limitations due to physical problems (RP). A correlation was noted between spirometry and blood gas results and SF-36 questionnaire results in IPF patients qualified for lung transplantation. There was a positive correlation between the partial pressure of oxygen (PaO2), on one side, and mental and general health, on the other. There also were positive correlations between FEV1 and SF and FEV1 and the level of bodily pain (BP). We conclude that the SF-36 questionnaire is a sensitive tool to assess the quality of life in IPF patients qualified for lung transplantation. The information gained can help assess the severity of the disease, clinical symptoms, and functional impairment in these patients.
5
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Left ventricular dysfunction in patients with interstitial lung diseases referred for lung transplantation

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Jastrzebski D., Nowak J., Ziora D., Wojarski J., Czyzewski D., Kozielski J., Polonski L., Zembala M.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
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