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1

Comparative analysis of CD4 and CD8 lymphocytes - evidences for different distribution in primary and secondary liver tumors

100%
Giusca S. E., Wierzbicki P. M., Amalinei C., Caruntu I.-D., Avadanei E. R.
Folia Histochemica et Cytobiologica
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2015
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tom 53
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nr 3
2

Aldehyde dehydrogenase isoenzymes in tumours - assay with possible prognostic value for oxazaphosphorine chemotherapy

84%
Wroczynski P., Laskowska A., Wierzchowski J., Szubert A., Polanski J., Slowiaczek M.
Acta Biochimica Polonica
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1998
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tom 45
|
nr 1
A novel fluorimetric assay, allowing independent measurement of the activities of two principal cytosolic forms of human aldehyde dehydrogenase, ALDH-1 and ALDH-3 (known as a tumour-associated ALDH) was applied to estimate the activities of these isoenzymes in human liver and thyroid tumours. The assay is based on two artificial substrates, 6-methoxy-2-naphthaldehyde (MONAL-62) and 7-methoxy-1-naphthaldehyde (MONAL-71), exhibiting excellent substrate properties toward various forms of human ALDH (see Wierzchowski et al., 1997, Anal. Biochem. 245, 69-78). We have found significant differences in ALDH activities between malignant and non-malignant tissue fragments, particularly in cancerous livers. Out of 16 tumours examined, only 4 exhibited ALDH-1 activities comparable to that found in the tumour-free tissue (0.5-2.5 U/g), while in the remaining 12 this activity was at least 10-fold lower. The ALDH-3 activity was detectable in about 40% of both tumour and tumour-free liver samples (maximum value 1.5 U/g). Comparison of 13 pathological thyroid fragments revealed ALDH activities in the range of 0.02 to 0.35 U/g, with two malignant samples showing activities of 0.27 and 0.18 U/g. Both substrate specificity and kinetic behaviour of the thyroid ALDH (Km values for the fluorogenic naphthaldehydes as well as propanal inhibition profile) were similar to those of the purified ALDH-1. In 5 thyroid samples traces of ALDH-3 activity was detected, using MONAL-62 and NADP+ as substrates (maximum value 0.04 U/g). Possible prognostic value of the foregoing measurements for cyclophosphamide chemotherapy is discussed.
3

Primary pleomorphic liposarcoma of the liver in a dog

67%
Galofaro V., Rapisarda G., Lanteri G., Marino F.
Polish Journal of Veterinary Sciences
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2008
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tom 11
|
nr 4
385-388
A rare case of primary pleomorphic liposarcoma of the liver in an 8-year-old female German shepherd dog is described. The liver tumour, measuring 10x12x5 cm, was located in the right hepatic lobe. The diagnosis of pleomorphic liposarcoma was based on the morphological and immunohis- tochemical features of the tumour cells. To our knowledge, this is the second case of primary liposarcoma of the liver in the dog found in the veterinary literature.
4

Effectiveness of capsaicin containing dried habanero pepper extract in the treatment of primary hepatic cancer in geriatric dogs

67%
Debiak P., Gadomska D., Smiech A., Zietek J., Lyp P., Lojszczyk-Szczepaniak A., Winiarczyk S., Adaszek L.
Medycyna Weterynaryjna
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2018
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tom 74
|
nr 12
The study was aimed at the preliminary clinical assessment of the anti-cancer efficacy of a dietary supplement based on the extract of habanero peppers containing capsaicin in dogs with primary hepatic cancer. 24 dogs with primary hepatic cancer, divided into two groups, were followed up during the study. Group I included 16 dogs receiving a dietary supplement based on capsaicin-containing habanero peppers, while group II consisted of 8 dogs that did not receive any veterinary treatment. The dogs were subjected to clinical examination, ultrasound imaging as well as biochemical and haematological analyses. Patient survival was determined in both groups. An autopsy was performed in all animals that died or were euthanised, and tumour samples were collected for histopathological examination, on the basis of which the type of neoplasm was finally determined. Survival of dogs in group I ranged from 54 to 285 days (178.6 days on average). Survival of dogs in group II was 32-128 days (76.5 days on average). In none of the dogs classified to group I that had single tumours did the size of the lesion increase during supplement administration, and in the case of two dogs that were receiving the preparation for a long time (188 and 285 days), their liver tumours actually shrank. In all dogs from group II that had single tumours, the size of the lesions increased in the course of the observation. The preliminary clinical observations by the authors indicate that the capsaicin-containing habanero pepper extract exhibits favourable effects on liver tumours in dogs and is well tolerated by the animals, thus the obtained results are a good sign for future studies on alternative medications used in dog oncology.
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