Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: liver metabolism

Sortuj według:

Ogranicz wyniki do:

Metabolic and antioxidative changes in liver steatosis induced by high-fat, low-carbohydrate diet in rabbits

100%

Birkner E., Kasperczyk S., Kasperczyk A., Zalejska-Fiolka J., Zwirska-Korczala K., Stawiarska-Pieta B., Grucka-Mamczar E.

Journal of Physiology and Pharmacology. Supplement

2005

tom 56

nr 6

45-58

Significantly decreased amounts of carbohydrates and increase of fat in diet (Atkins’ diet, Jan Kwaœniewski’s diet) may interfere with liver metabolism because main source of liver energy are carbohydrates. Large amount of fatty acid in diet may induce overproduction of reactive oxygen species in mitochondria because of increased oxidation and may cause steatosis. The influence of high-fat, low-carbohydrate diet (contained 14 g% protein, 25 g% fat, 8 g% carbohydrate) and compared to usual habitual diet (13 g% protein, 3 g% fat, 28 g% carbohydrate) as a control on liver function was examined in adult male rabbits. Fodder and water was ad libitum. The experiment lasted 24 weeks. At the beginning and every six weeks rabbits were weighed and blood was taken. Plasma glucose and cholesterol concentration, activity of glutamate dehydrogenase, alanine and aspartate in plasma and liver did not change. Concentrations of triacylglycerols (TG) in plasma were lower in the study group. Activity of aldolase increased in plasma and in liver in the study group while activity of sorbite dehydrogenase decreased in plasma at the end of the experiment. Malondialdehyde (MDA) concentration increased in aorta with no changes in liver and erythrocytes. Activity of glutathione peroxidase increased in erythrocytes and liver while total SOD increased only in the liver. High-fat, low-carbohydrate diet despite the lack of growth of the body mass, modifies significantly the homeostasis of carbohydrates and antioxidants in liver and enhanced production of TG in this organ, resulting in its steatosis.

Bile flow, vesicular trafficking, and interactions of cytoskeleton with the canalicular domain of hepatocyte plasma membrane

100%

Pikula S., Bandorowicz-Pikula J.

Cellular and Molecular Biology Letters

1996

tom 01

nr 2

Liver is an epithelial organ which removes many substances from the blood, metabolizes them, and secretes back into circulation or directly into the bile. Liver parenchymal cells (hepatocytes) are involved in the overall detoxification of the organism through the bile. These highly polarized cells are unique among others due to the domain structure of their plasma membrane, organization of their cytoskeleton connected to the canalicular region of plasmalemma, and the specific distribution of various transport systems involved in detoxification phase III. In this mini-review the possible influence of canalicular motility modulated by cytoskeleton on the bile flow is discussed. In addition, the role of annexins, calcium- and phospholipid-binding proteins exhibiting high expression level in liver, in vesicular trafficking leading to the transport of some of biliary components is also postulated.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Journal of Physiology and Pharmacology. Supplement

1 Bandorowicz-Pikula J.

1 Birkner E.

1 Grucka-Mamczar E.

1 Kasperczyk A.

1 Kasperczyk S.

1 Pikula S.

1 Stawiarska-Pieta B.

1 Zalejska-Fiolka J.

1 Zwirska-Korczala K.

1 2005

1 1996

Wyniki wyszukiwania

Metabolic and antioxidative changes in liver steatosis induced by high-fat, low-carbohydrate diet in rabbits

Bile flow, vesicular trafficking, and interactions of cytoskeleton with the canalicular domain of hepatocyte plasma membrane