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Rozwojowi przedwczesnych chorób układu krążenia, takich jak zawał mięśnia sercowego, często towarzyszą zaburzenia w metabolizmie lipidów, szczególnie hipertrójglicerydemia i dyslipoproteinemia. Praca ta zaznajamia ze stosowaną nomenklaturą i omawia kolejne etapy w metabolizmie lipidów i lipoprotein w zdrowiu i chorobie.
The effects of vegetable oils („non-erucic-acid” rapeseed oil and sunflower oil) and animal fat (butter) on the development of experimental atherosclerosis were studied in rabbits kept during 12 weeks on a cholesterol-rich diet. The degree of atherosclerotic changes by calculating planimetrically the site of the areas of fatty infiltrations in the aorta, the concentrations of total cholesterol, HDL-cholesterol, triglycerides lipid peroxides in the serum and ascorbic acid content in the tissues was determined. The cholesterol-rich diet caused development of atherosclerotic changes, increased serum cholesterol and lipid peroxide levels and ascorbic acid concentration in the studied tissues. „Non-eru- cid-acid” rapeseed oil slowed down the development of experimental atherosclerosis in a degree comparable to the effects of sunflower oil.
The aim of this study was to evaluate the effects of dietary supplementation of bamboo leaf extract (BLE) on the growth performance, antioxidant traits, immune function, and lipid metabolism of weaning piglets. After weaning at 21 days, two hundred and forty healthy piglets (Large White × Landrance) were randomly assigned to 4 treatments with 6 pens and 10 piglets per pen. The control group (Ctr) received a maize-soyabean based diet, and the test groups received the control diet plus 0.5%, 1%, or 2% (w/w) BLE, respectively. The experiment was carried out for 5 weeks. At the end of it, average daily feed intake in the 1% BLE group was decreased (p < 0.05). Plasma concentrations of malondialdehyde were decreased with supplementation of 1% and 2% BLE. Immunoglobulin G concentrations and lysozyme activity in plasma were significantly increased in piglets supplemented with BLE. Diets with 1% and 2% BLE increased (p < 0.05) plasma concentrations of low density lipoprotein-cholesterol and reduced (P < 0.01) high density lipoprotein-cholesterol levels. Higher triglyceride concentrations were observed in the 0.5% (P < 0.01) and 2% (p < 0.05) BLE groups. In conclusion, these novel findings demonstrate that supplementation of BLE to the diet improved the antioxidant activity, immune function, and lipid metabolism of weaning piglets.
Negative energy balance (NEB) is a common pathological cause of ketosis. As the major organs of lipid metabolism, the liver and fat tissue take part in regulating lipid oxidative capacity and energy demands, which is also a key metabolic pathway that regulates NEB development during the perinatal period. Fibroblast Growth Factor 21 (FGF21) is a novel metabolic regulator involved in the control of fatty acid oxidation and lipid metabolism during a prolonged negative energy balance. Our study determined a correlation between serum FGF21 and β-hydroxybutyric acid (BHBA) levels in dairy cows with ketosis. We used sixty cows with low milk yield, abnormal glucose metabolism, and ketosis. Serum FGF21 and BHBA levels were measured using commercial kits. Serum FGF21 increased with increasing BHBA levels up to 1.6 mmol/L. At BHBA levels > 1.6 mmol/L, FGF21 decreased. Serum FGF21 levels were positively associated with BHBA levels, particularly in dairy cows with subclinical ketosis (r = 0.647, P < 0.01). At BHBA levels between 1.2 mmol/L and 1.6 mmol/L, FGF21 was more closely correlated with BHBA than with other metabolic parameters. At BHBA levels > 1.6 mmol/L, the association between FGF21 and BHBA was not significant. In conclusion, our results show that FGF21 was closely related with SK in cows. FGF21 may be a promising regulator in the prevention of subclinical ketosis.
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