The purpose of the study was the assessment of the intensity of peroxidation processes during experimental hypercholesterolaemia and the comparison of the antioxidative action of beta-carotene with that of vitamins C and E. The experiment was cairied out on 50 guinea pigs receiving a diet containing 0.2% of cholesteroli A part of the animals received additionally beta-carotene (50 mg per 100 g of lhe diet), another part was given vitamin E (10 mg/ 100 g of the diet), vitamin C (500 mg/100 g of the diet) and beta-carotene (50 mg/ 100 g of the diet). Histological examinations of the thoracic and abdominal aorta demonstrated in hypercholesterolemia animals a significant reduction of lipid infiltrations in the group receiving supplements of these vitamins. Beta-carotene was found to inhibit the development of atherosclerotic lesion in the same degree as all three antioxidative vitajnins ailmitiislered jointly. In biochemical investigations it was shown that the administration of beta-carotene or the complex of antioxidative vitamins inhibited in the same degree the rise of TBA-IiS produced by high-cliolesterol diet. The study confirmed also a positive correlation between TBA-RS concentration an the activity of CK and CK-MB enzymes. The presence of vitamin C and E in the atherogenic diet exerted a more beneficial effect than beta-carotene on the distribution of cholesterol in HDL and LDL fractions.
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