Water extract of the Rhamnus cathartica fruits (RW) exhibited augmenting effect upon the PHA-induced proliferation of human lymphocytes obtained from healthy blood donors. Taking together with previously reported stimulation of human granulocyte enzymes it would be concluded that RW extract contained immunostimulatory components. RW also contained substances which were markedly cytotoxic to the lymphoid leukemic human cell lines. Further fractionation of RW and identification studies are necessary.
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