Wyniki wyszukiwania

1

Complex translocations with chromosome Philadelphia positive and negative in patients with chronic myelois leukemia [CML]

100%

Stanczak H., Brycz-Witkowska J., Chmarzynska-Mroz E., Malinowska J., Sachs W., Wasiutynski A., Jedrzejczak W. W.

Folia Histochemica et Cytobiologica. Supplement

|

2001

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tom 39

|

nr 1

2

Correlation between hyperdiploidy 51plus of acute lymphoblastic leukemia and DNA ploidy

100%

Brycz-Witkowska J., Sikorska-Fic B., Stanczak H., Chmarzynska-Mroz E., Rybczynska J., Wasiutynski A., Rokicka-Milewska R., Wasik M.

Folia Histochemica et Cytobiologica. Supplement

|

2001

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tom 39

|

nr 1

3

Expression of CD79a antigen in acute lymphoblastic leukaemias in children

100%

Nowicki M., Miskowiak B., Konwerska A.

Folia Histochemica et Cytobiologica

|

1999

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tom 37

|

nr 2

4

T-cell subsets in the murine thymus during chemically induced leukemogenesis

86%

Seidel H. J., Kreja L.

Folia Histochemica et Cytobiologica

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1986

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tom 24

|

nr 1

5

Expression of CD163 and HLA-DR molecules on the monocytes in chronic lymphocytic leukemia patients

86%

Kowalska W.

Folia Histochemica et Cytobiologica

|

2020

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tom 58

|

nr 1

6

Detection and molecular identification of Cryptosporidium species among children with malignancies

86%

Ibrahim H. S., Shehab A. Y., Allam A. F., Mohamed M. A., Farag H. F., Tolba M. M.

Acta Parasitologica

|

2021

|

tom 66

|

nr 2

7

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Exposure to electromagnetic fields and risk of leukemia

86%

Pachocki K. A., Gajewski A. K.

Roczniki Państwowego Zakładu Higieny

|

1991

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tom 42

|

nr 3

8

Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification

86%

Ciesla J., Fraczyk T., Zielinski Z., Sikora J., Rode W.

Acta Biochimica Polonica

|

2006

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tom 53

|

nr 1

Thymidylate synthase purified from 5-fluoro-dUrd-resistant mouse leukemia L1210 cells (TSr) was less sensitive to slow-binding inhibition by 5-fluoro-dUMP than the enzyme from the parental cells (TSp), both enzyme forms differing also in sensitivity to several other dump analogues, apparent molecular weights of monomer and dimer, and temperature dependence of the catalyzed reaction. Direct sequencing of products obtained from RT-PCR, performed on total RNA isolated from the parental and 5-fluoro-dUrd-resistant cells, proved both nucleotide sequences to be identical to the mouse thymidylate synthase coding sequence published earlier (NCBI protein database access no. NP_067263). This suggests that the altered properties of TSr are caused by a factor different than protein mutation, presumably posttranslational modification. As a possibility of rat thymidylate synthase phosphorylation has been recently demonstrated (Samsonoff et al. (1997) J Biol Chem 272: 13281), the mouse enzyme amino-acid sequence was analysed, revealing several potential phosphorylation sites. In order to test possible influence of the protein phosphorylation state on enzymatic properties, endogenous TSp and TSr were purified in the presence of inhibitors of phosphatases. Although both enzyme forms were phosphorylated, as shown by electrophoretical separation followed by phosphoprotein detection, the extent of phosphorylation was apparently similar. However, the same two purified enzyme preparations, compared to the corresponding preparations purified in the absence of phosphatase inhibitors, showed certain properties, including sensitivity to the slow-binding inhibition by FdUMP, altered. Thus properties dependence on phosphorylation was indicated.

9

In vitro activity of axazaphosphorines in childhood acute leukemia: preliminary report

86%

Styczynski J., Wysocki M., Debski R., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.

Acta Biochimica Polonica

|

2002

|

tom 49

|

nr 1

Glufosfamide (β-D-glucosyHfosfamide mustard) is a new agent for cancer chemotherapy. Its pharmacology is similar to commonly used oxazaphosphorines, but it does not require activation by hepatic cytochrome P-450 and preclinically demonstrates lower nephrotoxicity and myelosuppression than ifosfamide. The aim of the study was a comparison of the drug resistance profiles of glufosfamide and other oxazaphosphorines in childhood acute leukemias. Leukemic cells, taken from children with ALL on diagnosis (n = 41), ALL on relapse (n = 12) and AML on diagnosis (n = 13) were analyzed by means of the MTT assay. The following drugs were tested: glufosfamide (GLU), 4-HOO-ifosfamide (IFO), 4-HOO-cyclophosphamide (CYC) and mafosfamide cyclohexylamine salt (MAF). In the group of initial ALL samples median cytotoxicity values for GLU, IFO, CYC and MAF were 15.5, 33.8, 15.7 and 7.8,«M, respectively. In comparison with initial ALL samples, the relative resistance for GLU and IFO in relapsed ALL samples was 1.9 (p = 0.049) and 1.3 (ns), and in initial AML samples 31 (p < 0.001) and 5 (p = 0.001), respectively. All oxazaphosphorines presented highly significant cross-resistance. Glufosfamide presented high activity against lymphoblasts both on diagnosis and on relapse.

10

Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules

86%

Luczynski W., Stasiak-Barmuta A., Krawczuk-Rybak M., Szymanski M., Malinowska I., Mitura-Lesiuk M.

Acta Biochimica Polonica

|

2004

|

tom 51

|

nr 4

The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.

11

The effects of combined antifolates on inhibition of growth of murine leukemia cells cultured in vitro

86%

Balinska M., Szablewska I., Janiszewska D., Bartuzi K., Pawelczak K.

Acta Biochimica Polonica

|

1997

|

tom 44

|

nr 4

The synergistic effect of trimetrexate (TMTX) and sulphonamide derivatives of quinazoline on the cultured 5178Y murine leukemia cells was examined. On exposure to the slightly inhibitory concentrations of TMTX (0.1 nM) in combination with 2-desamino-2-methyl-10-propargyl-5,8-dideaza-pteroyl-sulphoglyc ine (DMPDDSF) (0.02 microM) a synergistic inhibitory effect of the antifolates on cell growth was observed. These two drugs in the same combination caused also synergistic inhibition of de novo synthesis of thymidylate in intact cells as measured by tritium release from [5-(3)H]deoxyuridylate. This was accompanied by a marked reduction in intracellular concentration of 5,10-methylenetetrahydro-pteroyl-polyglutamate (5,10CH2H4PteGlu(n)) (0.2 microM) and dihydropteroyl-polyglutamate (0.12 microM). In these conditions de novo biosynthesis of purine was decreased by 50%. These observations show that growth inhibition by combined antifolates is mediated by intracellular depletion of the substrate of thymidylate synthase -- 5,10CH2H4PteGlu(n). The results obtained strongly suggest that under certain conditions inhibition of thymidylate synthesis by DMPDDSF is intensified by prior application of TMTX -- an inhibitor of dihydrofolate reductase.

12

Ecto-5'-nucleotidase activity and CD73 expression in patients at different stages of the B-cell chronic lymphocytic leukemia

86%

Rosi F., Marotta G., Raspadori D., Bellisai B., Marinello E., Carlucci F., Tabucchi A.

Cellular and Molecular Biology Letters

|

1999

|

tom 04

|

nr 3

13

Lower expression of mRNA for interferon-gamma in T helper cells of children with newly diagnosed lymphomas

86%

Luczynski W., Kovalchuk O., Krawczuk-Rybak M., Mitura-Lesiuk M., Malinowska I., Chyczewski L., Kowalczyk J., Matysiak M.

Folia Histochemica et Cytobiologica

|

2005

|

tom 43

|

nr 3

14

Cytotoxic effects of cladribine and tezacitabine toward HL-60

86%

Stachnik K., Grieb P., Skierski J. S.

Acta Biochimica Polonica

|

2005

|

tom 52

|

nr 2

The aim of the study was to determine the relation between the cytotoxic and cytostatic effects of tezacitabine and cladribine on a HL-60 cell line and the time of exposure of cells to these drugs. Cell viability and induction of apoptosis were assessed using flow cytometry methods. Apoptosis was confirmed by direct microscopic observation. Growth inhibition was examined by cell counting. After 24 h incubation tezacitabine was equally or less toxic compared to cladribine. However, toxicity of tezacitabine strongly rose after 48 h incubation leading to massive cell death at doses much lower than those of cladribine. Assessment of the effect of increased exposure time on the clinical efficacy of tezacitabine is indicated.

15

Humoral immune response in children with acute lymphoblastic leukaemia following influenza vaccination

86%

Brydak L. B., Rokicka-Milewska R., Jackowska T., Machala M.

Bulletin of the Veterinary Institute in Puławy

|

1998

|

tom 42

|

nr 1

16

A transferrin conjugate of adriamycin-synthesis and potential chemotherapeutic efficacy

86%

Lubgan D., Jozwiak Z.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

17

Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: Preliminary report

86%

Styczynski J., Wysocki M., Debski R., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.

Acta Biochimica Polonica

|

2002

|

tom 49

|

nr 1

In vitro antileukemic activity of five glucocorticoids and their cross-resistance pattern in childhood acute lymphoblastic and non-lymphoblastic leukemia were determined by means of the MTT assay in 25 leukemia cell samples of childhood acute leukemias. The equivalent antileukemic concentrations of the drugs tested were: 34 uM hydrocortisone (HC), 8 uM prednisolone (PRE), 1.5 uM methylprednisolone (MPR), 0.44 uM dexamethasone (DX) and 0.22 Mbetamethasone (BET). In comparison with initial ALL cell samples, the relapsed ALL group was more resistant to PRE (38-fold, p = 0.044), DX (> 34-fold, p = 0.04), MPR (38-fold), BET (45-fold) and HC (33-fold). TheAMLcell samples were even more resistant to: PRE (>85-fold, p=0.001), DX (> 34-fold, p = 0.004),MPR(> 69-fold, p = 0.036), BET (> 69-fold, p = 0.038) and HC (54-fold, p = 0.059) when compared with ALL on initial diagnosis. A significant cross-resistance among all the glucocorticoids used was found. Only in some individual cases the cross-resistance was less pronounced.

18

DNA repair in drug resistance induced by fusion tyrosine kinases

86%

Blasiak J.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

|

nr Suppl.

19

Cytogenetic studies in chronic myeloid leukemia

86%

Chmarzynska-Mroz E., Brycz-Witkowska J., Stanczak H., Boguradzki A., Wasiutynski A., Jedrzejczak W. W.

Folia Histochemica et Cytobiologica. Supplement

|

2001

|

tom 39

|

nr 1

20

The purine nucleotide content in human leukemia cell lines

86%

Baranowska-Bosiacka I., Machalinski B., Tarasiuk J.

Cellular and Molecular Biology Letters

|

2005

|

tom 10

|

nr 2

Ograniczanie wyników

Complex translocations with chromosome Philadelphia positive and negative in patients with chronic myelois leukemia [CML]