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Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer

100%

Barsoum A. L., Schwarzenberger P. O.

Cellular and Molecular Biology Letters

2014

tom 19

nr 3

The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation processes to become a non-immunogenic 67-kDa dimeric mature laminin receptor protein (mLRP) in mid-to late gestation in the mammalian fetus. This antigen ceases to be expressed as an active autoimmunogen in the full-term fetus and in the normal differentiating tissues and organs of the neonate or adult organism, apparently due to dimerization, but it is re-expressed as an immunogenic monomer in tumor cells. In this review, we highlight the known mechanisms of immune responses with particular emphasis on the possible role of the 37-kDa oncofetal antigen/immature laminin receptor (OFA/iLRP) in both pregnancy and cancer.

siRNA-mediated silencing of the 37-67-kDa high affinity laminin receptor in Hep3B cells induces apoptosis

84%

Susantad T., Smith D. R.

Cellular and Molecular Biology Letters

2008

tom 13

nr 3

452-464

The laminin-binding protein, variously called the 37/67-kDa high affinity laminin receptor or p40, mediates the attachment of normal cells to the laminin network, and also has a role as a ribosomal protein. Over-expression of this protein has been strongly correlated with the metastatic phenotype. However, few studies have investigated the cellular consequence of the ablation of this gene’s expression. To address this issue, the expression of the 37/67-kDa high affinity laminin receptor was knocked out with several siRNA constructs via RNA interference in transformed liver (Hep3B) cells. In each case where the message was specifically ablated, apoptosis was induced, as determined by annexin V/propidium iodide staining, and by double staining with annexin V and an antibody directed against the 37/67-kDa high affinity laminin receptor. These results suggest that this protein plays a critical role in maintaining cell viability.

Ograniczanie wyników

2 Cellular and Molecular Biology Letters

1 Barsoum A. L.

1 Schwarzenberger P. O.

1 Smith D. R.

1 Susantad T.

1 2014

1 2008

Wyniki wyszukiwania

Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer

siRNA-mediated silencing of the 37-67-kDa high affinity laminin receptor in Hep3B cells induces apoptosis