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The case of a massive Syphacia obvelata invasion in laboratory rats: diagnosis, treatment and prevention

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Michalski M., Chmielewska-Krzesinska M., Jakimiuk A., Losiewicz K.

Annals of Parasitology

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2016

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tom 62

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nr Suppl.

2

Estimating the number of newborn animals in enclosed population in laboratory mice

100%

Adamczyk K., Walkowa W.

Acta Theriologica

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1974

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tom 19

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nr 14-25

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Application of photodynamic therapy in the sterilisation of tumour cells transplanted into laboratory animals

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Jurczyszyn K., Ziolkowski P., Klytta M., Piasecki T.

Bulletin of the Veterinary Institute in Puławy

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2009

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tom 53

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nr 1

123-128

In this study, we tried to estimate the effectiveness of the antimicrobial activity of photodynamic therapy (PDT) without the destruction of tumour cells. Chlorin e6 in concentrations from 0.05 to 1.0 µg/mL and total dose of light 100 J/sq.cm were used. Samples from different tumours were tested for a presence of bacteria. Next, cells from the same tumours were treated with chlorin e6-PDT, chlorin e6, and light alone, or not treated. The survival rate was counted, and the cells were injected back into the animals. PDT caused the eradication of bacteria such as Proteus sp., Streptococcus α-haemolyticus, and others: the specimen became aseptic. After Ce6-PDT treatment and in control groups, tumour growth was observed in all rats 7-10 d after transplantation. The tumours were palpable and macroscopically visible. Our studies showed that PDT kills bacterial flora without the destruction of tumour cells. Thus, tumour cells free of bacteria could be used for other experiments.

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Heavy metal content in environmental enrichment used for laboratory rodents

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Ochniewicz P., Karczmarczyk U., Sochaczewski L., Laszuk E., Garnuszek P.

Zeszyty Problemowe Postępów Nauk Rolniczych

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2019

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tom 597

5

Ultrasonic vocalizations (USV) in the three standard laboratory mouse strains: developmental analysis

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Wiaderkiewicz J., Glowacka M., Grabowska M., Barski J.-J.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 4

Mice, similarly to some other rodent species, communicate with specialized sounds in the ultrasonic range called ultrasonic vocalizations (USV). Evaluation of this behavioral activity enables estimation of the social interactions in animal models of autistic spectrum disorders (ASD). Because transgenic mouse models are generated, in most cases, on the mixed 129SV/ C57BL6 genetic background, we were interested if parameters that characterize USV differ between these two mouse strains. In addition, we wanted to compare these strains with the BALB/c line. In order to analyze USV, we applied the standard isolation test to newborn animals and compared standard parameters. Obtained results indicate clear differences between the 129SV and C57BL6 strains in respect to all analyzed USV parameters. Both strains behave also differently when compared with the BALB/c strain. For this reason in experiments utilizing transgenic animals, contribution of various genetic backgrounds has to be carefully considered.

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Selected blood serum biochemical indicators in twelve inbred strains of laboratory mice

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Wirth-Dzieciolowska E., Karaszewska J., Sadowski T., Pysniak K., Gajewska M.

Animal Science Papers and Reports

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2009

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tom 27

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nr 2

159-167

A total of 215 animals of twelve inbred strains of mice (A.CA/W, AKR/W, BALB/cW, BN/aW,C57BL/6W, C57Bl/10W, CBA/W, CBAT6/W, C3H/W, DBA/2W, 129Sl/SvW and HLB/219J) bred at the Cancer Centre and Institute of Oncology, Warsaw (Oncology Centre), were characterized In terms of five blood serum biochemical indicators related to their health, reproduction and genetic background. Glucose, total protein, creatinine, triglycerides (triacylglycerols) and total cholesterol were determined in mice aged four months. Significant interstrain differences were found among nearly all parameters considered, with the exception of total protein. The level of triglycerides showed wide interstrain differences and revealed a similar variation trend as the total cholesterol.For cholesterol and triglycerides, significant differences between sexes for the majority of strains were found. The results obtained may be important in the selection of experimental animals,for analysis of changes associated with various diseases, and for the explanation of their genetic background.

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Comparative studies on mast cell distribution in the skin of humans and laboratoty animals. A preliminary report

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Godlewski A., Dobek-Smiech J., Zielinski A.

Folia Histochemica et Cytobiologica. Supplement

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1996

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tom 34

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nr 1

8

Test Draize'a i alternatywne metody oceny dzialania drazniacego substancji chemicznych

84%

Moskalewski S., Mystkowska E. T., Kiss E.

Roczniki Państwowego Zakładu Higieny

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1995

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tom 46

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nr 2

163-168

Potencjał właściwości drażniących substancji chemicznych jest obecnie oceniany zdolnością do wywoływania podrażnienia oka królika (test Draize'a). Ze względów humanitarnych zaleca się zastąpienie tego testu testami alternatywnymi. Niniejszy artykuł jest przeglądem testów alternatywnych do testu Draize'a, wykonywanych w laboratoriach krajów Wspólnoty Europejskiej, jednocześnie jest dyskutowana czułość metod oraz ich powtarzalność.

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Selected peripheral blood cell parameters in twelve inbred strains of laboratory mice

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Wirth-Dzieciolowska E., Karaszewska J., Pysniak K., Smolinska M., Gajewska M.

Animal Science Papers and Reports

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2009

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tom 27

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nr 1

69-77

In 230 mice from 12 inbred strains (A.CA/W, AKR/W, BALB/cW, BN/aW, CBA/W, CBA-T6/W,C3H/W, C57BL/6W, C57BL/10W, DBA2/W, 129S1/SvW, HLB219/J) the following parameters were measured: the total number of white (WBC) and red (RBC) blood cells, haemoglobin concentration (HGB), haematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and platelets (PLT) number. Highly significant interstrain differences were shown within RBC, HGB, HCT, MCV and PLT.

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Wplyw podostrego zatrucia chlorfenwinfosem szczurow na aktywnosc aminotransferaz [AST i ALT]

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Jeleniewicz K., Maciejewska-Kozak H.

Bromatologia i Chemia Toksykologiczna

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2001

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tom 34

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nr 2

181-183

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Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats

84%

Esatgil M. U., Gulanber A., Aydin H.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 1

67-69

Efficacy of selamectin was studied in naturally acquired S. muris infections in rats. Fourty-eight 5. muris-positive rats were divided into six treated and two control groups. Selamectin (6 mg/kg) was applied topically to the skin in a single spot at the base of the neck in the treatment group. The rats of treated and control groups were necropsied on the 24th day after the treatment. Topical selamectin was found to be 40.7-63.3% effective (based on egg per gram method) in eliminating S. muris infection in rats. The efficacy of the treatment against S. muris (based on adult worm counts) in male and female rats was 35.14-58.88%, respectively (mean 48.39%).

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Interaction of tiagabine with clonazepam in the mouse pentylenetetrazole-induced seizure model: a type I isobolographic analysis for parallel log-probit dose-response relationship lines

84%

Luszczki J. J., Krzyzanowski M., Sielski M., Wojda E., Swiader M. J.

Journal of Pre-Clinical and Clinical Research

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2008

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tom 02

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nr 2

13

Use of topical selamectin for the treatment of Trichosomoides crassicauda infection in laboratory rats

84%

Esatgil M. U., Gulanber A., Aydin H.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 2

143-145

The present study investigated the efficacy of topical selamectin for elimination of naturally acquired Trichosomoides crassicauda infection in rats. Twelve T. crassicauda-positive rats were assigned to the treatment group and six rats were assigned to the control group. Selamectin (6 mg/kg) was applied topically to the skin in a single spot at the base of the neck in front of the scapulae in the treatment group. To assess the efficacy of the treatment, animal faeces were investigated with the use of the flotation technique on days 0, 4, 14 and 24 after selamectin application. The rats of the treatment and control groups were necropsied on the day 24. In the treatment group, 7 of 12 infected rats were cured completely. Topical selamectin was found to be effective in eliminating T. crassicauda infection in rats.

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Chokeberry polyphenols reduce prooxidative influence of oxidized fats in rat diets

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Frejnagel S. S., Zdunczyk Z.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 2

125-132

The aim of the study was to estimate nutritional and physiological consequences of combined supplementation of rat casein diets with a strongly oxidized mixture of fats and extract of polyphenols from chokeberry. The experiment was conducted on 80 young Wistar rats divided into 8 groups. The animals were fed diets supplemented with 8% of fresh or oxidized fats and 0.4, 0.8 and 1.2% of polyphenol extract together. Addition of the oxidized fats caused significant reduction in animal growth without a decrease in nitrogen digestibility. On the other hand, the extract of polyphenols suppressed nitrogen utilization; animal growth was however similar to the control group. Analysis of the variance showed negative influence of the oxidized fats on cholesterol and triacyloglycerol concentration in the blood of the experimental animals. Increased activity of both aminotransferases in the blood of rats fed diets containing the oxidized fats indicated on liver malfunction. There was no effect of the experimental factors on the antioxidant status of the blood, but a dose-dependent reduced content of malonylodialdehyde in the blood of rats fed diets supplemented with the extract of polyphenols suggested that the extract had a preventive effect against prooxidative activity of the oxidized fats.

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Conjugated linoleic acid decreased serum triacyloglycerol and changed fatty acid composition in rat’s liver

84%

Kostogrys R. B., Pisulewski P. M.

Journal of Animal and Feed Sciences

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2010

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tom 19

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nr 3

Extensive research have indicated that commercial conjugated linoleic acid (CLA), fed to laboratory animals, showed several health-related properties. The objective of this study was to assess the effect of CLA on serum lipid profile, plasma malondialdehyde and liver fatty acids profile in Wistar rats fed for 23 d. The experimental diets were: I-AIN-93G - control (C), II- AIN-93G diet + 1.0% CLA. The CLA oil contained 600 g CLA/kg, with equal representation of cis-9,trans-11 and trans-10,cis-12 CLA isomers. The experimental treatments had no effect on rats body weight, total cholesterol, HDL, LDL+VLDL and malondialdehyde. The triacylglycerol (TG) was significantly decreased after CLA supplementation. Liver weight, fat and histology were unchanged in CLA group. Liver cholesterol was insignificantly decreased in CLA diet. Dietary treatments had significant effects of on proportions of SFA and MUFA and PUFA in liver. In conclusion, CLA decreases serum TG. Additionally, liver fat composition were changed after CLA supplementation

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Wyniki stosowania w hodowli szczurów doświadczalnych diety wytwarzanej fabrycznie

84%

Wysocki E.

Roczniki Państwowego Zakładu Higieny

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1963

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tom 14

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nr 6

17

Toksycznosc eteru dekabromodifenylowego w warunkach ekspozycji jednorazowej szczurow

84%

Bruchajzer E., Szymanska J. A.

Bromatologia i Chemia Toksykologiczna

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2007

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tom 40

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nr 4

395-400

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Immunolocalization in portal acinus of the liver of different types of adriamycin induced cell death depending on time

84%

Pedrycz A., Boratynski Z., Mendocha J.

Medycyna Weterynaryjna

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2014

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tom 70

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nr 02

The ability to control the phenomenon of apoptosis, its induction or inhibition, raises hopes for treating many diseases including cancer. Adriamycin, an antibiotic that is wildly used after treating cancer, induces apoptosis in liver cells in a certain and relatively quick way after its application. The aim of the work was to obtain and examine the model of apoptosis and necrosis of hepatocytes with respect to their response to different damaging stimuli (adriamycin) depending on the time after the application in correlation with the ultrastructural construction, which is the result of the different location of hepatocytes within the portal acinus (of Rappaport). There were 32 female white Wistar rats used in the study. They were divided into 4 groups (2 experimental and 2 control), 8 animals in each group. The adriamycin dose of 5 mg/kg was administered intraperitoneally to the rats in groups I and II and then the rats were decapitated after 4 weeks (group I) and after 8 weeks (group II). The rats in the control groups were given 0.5 ml 0.9% NaCl solution and then decapitated after 4 weeks (group III) and 8 weeks (group IV). In the research, preparations made from fragments of the right liver lobe were used for histological observations and immunohistochemical studies. In the immunohistochemical studies, a three-stage method was used. According to this method, hepatocytes were examined qualitatively and quantitatively for the presence of proteins involved in apoptosis, to which the death signals run: through mitochondrial pathways (caspase 3 and caspase 9), through intrinsic pathways by endoplasmic reticulum (caspase 3 and caspase 12), through extrincic pathways (caspase 3 and caspase 8) and one from inflammatory markers: caspase 1. Histological images showed that the apoptosis phenomenon occurs after the administration of adriamycin in hepatocytes in a zonate way and is dependent on the time that has elapsed since its administration. Immunohistochemical studies showed, in both a qualitative and quantitative way, a phenomenon of apoptosis in hepatocytes (executive caspase 3) and necrosis (caspase 1). It was also proved that the signal for the induction of apoptosis showed zonation and mainly followed the mitochondrial pathway (caspase 9); the intrinsic pathway by endoplasmic reticulum was much less common (caspase 12); while even more rarely caspase 8 was identified as a marker of an extrinsic pathway to induce apoptosis.

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The influence of Rhodiola quadrifida 50 per cent hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice

84%

Skopinska-Rozewska E., Malinowski M., Wasiutynski A., Sommer E., Furmanowa M., Mazurkiewicz M., Siwicki A. K.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 2

97-104

The genus Rhodiola (Crassulaceae) consists of more than 100 species. They grow mainly in Tibet, China and Mongolia and are traditionally used as tonic, adaptogen , antidepressant and anti-inflammatory drugs. The best known is Rhodiola rosea (R. rosea) now cultivated also in Europe and North America, and present on the market as dietary supplement. Some authors reported anti-tumor activity of R. rosea extracts. Recently, we have published some data on immunomodulatory and antiangiogenic properties of R. rosea. Rhodiola quadrifida (R. quadrifida) belongs to the same family, but is almost not known in Europe, and there is no information about its possible anti-tumor as well as immunotropic and angiotropic activity. The aim of this study was to determine the influence of 50% hydro-alcoholic extract from rhizomes of R. quadrifida (Mongolian origin) and its main biologically active compound salidroside on tumor-induced angiogenesis. Angiogenesis was induced in the skin of Balb/c mice by grafting of syngeneic L-l sarcoma cells. Mice were fed R. quadrifida extract or salidroside in daily doses 40, 200 and 400 μg, or 0.5, 1, 2, and 4 μg, respectively. After 72 hours, mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope. Results: It was found that R. quadrifida extract and salidroside highly significantly decreased neovas- cular reaction in all doses applied.

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A pilot study on the histochemical evaluation of Na-K-ATPase and succinate dehydrogenase in rat intestinal villi

84%

Grudzinski I. P.

Roczniki Państwowego Zakładu Higieny

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2002

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tom 53

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nr 1

Effects of poisoning with sodium nitrite on Na/K-ATPase and succinate dehydrogenase (SDH) activity were examined in the small intestine mucosa of male Wistar rats. The animals were treated per os with either an aqueous solution of sodium nitrite (10 mg NaNO2/kg b.w.) or normal saline (control) daily for 3 or 12 weeks. Histochemical analyses show that sodium nitrite decreased Na/K-ATPase and SDH in rat intestinal villi, and the nitrite side effect(s) was mainly observed in animals treated for 12 weeks.

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