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Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients

100%

Gackowski D., Kruszewski M., Banaszkiewicz Z., Jawien A., Olinski R.

Acta Biochimica Polonica

2002

tom 49

nr 1

Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.

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Association between body iron stores and level of oxidatively modified DNA bases

80%

Dziaman T., Jurgowiak M., Olinski R.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2011

tom 92

nr 2

Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines

80%

Kruszewski M., Iwanenko T.

Acta Biochimica Polonica

2003

tom 50

nr 1

Labile iron pool (LIP) constitutes a crossroad of metabolic pathways of iron-containing compounds and is midway between the cellular need for iron, its uptake and storage. In this study we investigated oxidative DNA damage in relation to the labile iron pool in a pair of mouse lymphoma L5178Y (LY) sublines (LY-R and LY-S) differing in sensitivity to hydrogen peroxide. The LY-R cells, which are hydrogen peroxide-sensitive, contain 3 times more labile iron than the hydrogen peroxide-resistant LY-S cells. Using the comet assay, we compared total DNA breakage in the studied cell lines treated with hydrogen peroxide (25 uM for 30 min at 4°C). More DNA damage was found in LY-R cells than in LY-S cells. We also compared the levels of DNA lesions sensitive to specific DNA repair enzymes in both cell lines treated with H2O2. The levels of endonuclease Ill-sensitive sites and Fapy-DNA glycosylase-sensitive sites were found to be higher in LY-R cells than in LY-S cells.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

2 Kruszewski M.

2 Olinski R.

1 Banaszkiewicz Z.

1 Dziaman T.

1 Gackowski D.

1 Iwanenko T.

1 Jawien A.

1 Jurgowiak M.

1 2011

1 2003

1 2002

Wyniki wyszukiwania

Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients

Association between body iron stores and level of oxidatively modified DNA bases

Labile iron pool correlates with iron content in the nucleus and the formation of oxidative DNA damage in mouse lymphoma L5178Y cell lines