Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 28

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  ksenotransplantacje
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
The number of patients waiting for transplants has increased despite the constant growth of the number of transplants performed. This is the reason why the possibility of using animal organ donors is taken into consideration. Since 2002, the problems concerning xenotrasplantation have been investigated in Poland in the frame of the project: Application of trangenesis in genetic modification of pigs in order to gain organs for transplantation in humans. In the presented paper the possibility of use of transgenic pig kidneys for allogenic and heterogenic transplantation in clinical aspect was evaluated, with the special compliance of surgical methods. The proposed surgical technique of kidney transplantation in pigs derived from the methods used in human medicine and consisted of three stages: the operation of collecting the kidneys en-block, preservation of collected organs and their transplantation. The aim of the first stage was the isolation of the both donor kidneys as fast as possible in a manner not causing the injury of kidney parenchyma, with the maintenance of all anatomical and functional structures and blood vessels. In the study, 3 non-transgenic and 6 transgenic sows with the block of the gene á1,3GT were evaluated. In the presented studies the modification of the routine technique of kidney collection used in human transplantology was performed with the possibility of application of the method for allo- and xenotranplantation in pigs. The maintenance of the defined conditions of perfusion and storage of the collected organs is the requirement of the preservation of viability of the transplant for the time necessary for preparing the organ and the recipient for the transplantation.
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Ksenotransplantacja - szansa czy zagrożenie?

63%
In the conducted study the possibility of using the transgenic pig kidneys for allogenic and heterogenic transplantation was evaluated with regards to the clinical context. There were 3 nontransgenic and 6 transgenic pig donors with a human α1.3-fukosylotransferase gene. The recipient of the kidneys were 6 nontransgenic and 3 transgenic pigs. The kidneys were heterotopic transplantated to intraperitoneal space. The kidney was transplanted to the left side at the level of 4-5 lumbar vertebra with end-to-side anastomosis of the renal vein and artery with vena cava caudale and aorta, respectively. The proposed surgical model of homological transplantation of kidneys in pigs allows for rapid organ collection without disturbing the structure, with continuous and tight vessel. The immunological response on the base of the changed levels of IL-1, IL-4 IL-6 IL-10 TNF-α and INF-γ in the serum were investigated. The acute immunological rejection of the graft was found on cell and humoral bases. There was a weaker immunological response after the transplantation of transgenic kidneys in comparison to nontransgenic ograns. Transgenesis has a positive effect on the immunological response.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.