Wyniki wyszukiwania

1

Pharmacological attenuation of Paramecium fluid-phase endocytosis

100%

Wiejak J., Surmacz L., Wyroba E.

Folia Biologica

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2007

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tom 55

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nr 3-4

2

Relations between markers of cardiac remodelling and left ventricular collagen in an isoproterenol-induced heart damage model

84%

Adamcova M., Baka T., Dolezelova E., Aziriova S., Krajcirovicova K., Karesova I., Stanko P., Repova K., Simko F.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 1

3

Isoproterenol induces in vivo functional and metabolic abnormalities; similar to those found in the infarcted rat heart

67%

Heather L. C., Catchpole A. F., Stuckey D. J., Cole M. A., Carr C. A., Clarke K.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 3

31-39

Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol on in vivo cardiac function and substrate metabolism are unknown. Isoproterenol (5 mg.kg-1.day-1) was infused for 7 days in male Wistar rats (n = 22). In vivo magnetic resonance imaging (MRI) showed that left ventricular mass increased by 37% and end-diastolic and systolic volumes increased by 33% and 73%, respectively, following isoproterenol infusion. Cardiac function at the base of the left ventricle was normal, but apical ejection fraction decreased from 90% to 31% and apical free wall thickening decreased by 94%, accompanied by increased fibrosis and inflammation. Myocardial palmitate oxidation rates were 25% lower, and citrate synthase and medium chain acyl-coenzyme A dehydrogenase activities were reduced by 25% and 29%, respectively, following isoproterenol infusion. Fatty acid transporter protein levels were 11-52% lower and triglyceride concentrations were 55% lower in isoproterenol-infused rat hearts. Basal glycolysis and glycogen concentration were not changed, yet insulin stimulated glycolysis was decreased by 32%, accompanied by 33% lower insulin stimulated glucose transporter, GLUT4, protein levels in rat hearts following isoproterenol infusion, compared with controls. In conclusion, isoproterenol infusion impaired in vivo cardiac function, induced hypertrophy, and decreased both fatty acid and glucose metabolism, changes similar in direction and magnitude to those found in the rat heart following moderate severity myocardial infarction.

4

Nonspecific effects of ligands on the beta-adrenergic receptors in rabbit abdominal aorta in vitro

67%

Gnus J., Czerski A., Bujok J., Ferenc S., Zawadzki W., Witkiewicz W., Hauzer W., Rusiecka A., Janeczek M.

Folia Biologica

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2013

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tom 61

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nr 3-4

5

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Catecholaminergic regulation of the hypothalamic-pituitary-adrenocortical activity

67%

Bugajski J., Turon M., Gadek-Michalska A., Borycz J. A.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 1

The significance and site of adrenergic receptors involved in the control of the hypothalamic-pituitary-adrenal axis (HPA) activity was assessed indirectly by estimation of serum corticosterone levels 1 h after drug administration to conscious rats. Adrenergic drugs were given intracerebroventricularly (icv) and intraperito neally (ip), the antagonists 15 min prior to the agonists. Noradrenaline, adrenalin and isoproterenol given by either route increased dosedependently the serum corticosterone levels. The corticosterone response to icv noradrenaline was almost abolished by icv pretreatment with propranolol, a ß-adrenergic antagonist, and yohimbine, an α₂ -receptor blocker, and was also considerably reduced by prazosin, an α₂- adrenergic antagonist. When given ip, these antagonists did not significantly influence the noradrenaline induced corticosterone response, which suggests a suprapituitary site of action of noradrenaline in stimulation of the HPA. The corticosterone response to icv adrenalin was suppressed by prazosin given by either route. The corticosterone response to ip adrenalin was almost abolished by pretreatment with yohimbine, and also significantly diminished by propranolol given by the same route. The increase in corticosterone secretion, induced by isoproterenol given by either route, was abolished by ip injection of propranolol. These results indicate that noradrenaline stimulates the HPA via α and ß-adrenergic receptors, mainly at the suprapituitary level. Adrenalin increases that activity both via central and pituitary a and ß-adrenoceptors. Isoproterenol activates the HPA by stimulation of pituitary ß-receptors.

6

Adrenergic regulation of the hypothalamic-pituitary-adrenal axis under basal and social stress conditions

67%

Bugajski J., Gadek-Michalska A., Olowska A., Borycz J., Glod R., Bugajski A. J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 3

7

The influence of adrenergic and cholinergic agents on the respiratory burst of human neutrophils from peripheral blood and synovial fluid

67%

Gajewski M., Gujski M., Ksiezopolska-Pietrzak K., Jozwicka M., Maslinski S.

Journal of Physiology and Pharmacology. Supplement

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1997

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tom 48

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nr 2

Ograniczanie wyników

Pharmacological attenuation of Paramecium fluid-phase endocytosis

Relations between markers of cardiac remodelling and left ventricular collagen in an isoproterenol-induced heart damage model

Isoproterenol induces in vivo functional and metabolic abnormalities; similar to those found in the infarcted rat heart

Nonspecific effects of ligands on the beta-adrenergic receptors in rabbit abdominal aorta in vitro

Catecholaminergic regulation of the hypothalamic-pituitary-adrenocortical activity

Adrenergic regulation of the hypothalamic-pituitary-adrenal axis under basal and social stress conditions

The influence of adrenergic and cholinergic agents on the respiratory burst of human neutrophils from peripheral blood and synovial fluid