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Influence of Lydium KPL upon morphology of lung tissue and serum cytokine level in irradiated rats

100%

Staroslawska E., Roszkowski J., Kozaczynski W., Donica H., Bachanek T., Jarmolinska K., Bozyk A., Moskwa A.

Bulletin of the Veterinary Institute in Puławy

2001

tom 45

nr 1

The modifying influence of Lydium KLP upon the early postirradiation reaction in rats was studied. The effects of Lydium KLP upon the intensity of irradiation reaction was monitored in morphological examinations of the trachea and lung tissue and concentrations of chosen blood plasma proinflammatory cytokines. The experiment was carried out on four groups of Wistar rats: (1) not irradiated (control), (2) administered with Lydium KLP, (3) irradiated and (4) irradiated with Lydium KLP administration. After three months the animals were sacrificed and histopathological examinations of the trachea and lung sections were performed. The concentrations of TNFa, IL-6 chemotactic factor MIP-2 were determined with commercial kits. It was found that postirradiation reduced the damage of the trachea and lung tissue in the group of rats irradiated with simultaneous administration of Lydium KLP. However, the concentrations of proinflammatory cytokines in the group of rats irradiated with simultaneous administration of Lydium KLP were higher in comparison to the group irradiated, not treated with Lydium KLP.

Effect of Solcoseryl on the apoptosis in the lungs of experimentally irradiated rats

100%

Staroslawska E., Donica H., Kozaczynski W., Wojcierowski J., Jarmolinska K., Wolanska E., Bozyk A.

Bulletin of the Veterinary Institute in Puławy

2001

tom 45

nr 1

Modifying effect of Solcoseryl upon the late postirradiation damage of the lungs expressed as the number of apoptotic cells per 1mm² of the pulmonary tissue was investigated in rats. The number of labelled apoptotic cells in situ was determined by TUNEL method under light microscope connected to computer imaging (Lucia software). The results of the experiment demonstrated statistically significant reduction in the number of apoptotic cells in the pulmonary tissue in the group of rats irradiated with simultaneous administration of Solcoseryl in comparison to the group of animals irradiated without Solcoseryl treatment. The results indicate that Solcoseryl exhibits radioprotective activity upon the respiratory epithelium due to the reduction of the apoptotic cell number.

Ograniczanie wyników

2 Bulletin of the Veterinary Institute in Puławy

2 Bozyk A.

2 Donica H.

2 Jarmolinska K.

2 Kozaczynski W.

2 Staroslawska E.

1 Bachanek T.

1 Moskwa A.

1 Roszkowski J.

1 Wojcierowski J.

1 Wolanska E.

2 2001

Wyniki wyszukiwania

Influence of Lydium KPL upon morphology of lung tissue and serum cytokine level in irradiated rats

Effect of Solcoseryl on the apoptosis in the lungs of experimentally irradiated rats