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On the metabolism of prostaglandin E1 administered intravenously to human volunteers

100%

Peskar B. A., Cawello W., Rogatti W., Rudofsky G.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 3

We have demonstrated recently the formation of a biologically active metabolite of prostaglandin (PG) E₁, 13,14-dihydro-PGE₁, during intravenous infusions of PGE₁ in patients with peripheral arterial occlusive disease. We have now investigated the levels of the immediate precursor of 13,14-dihydro-PGE₁ , the biologically inactive 15-keto-13,14-dihydro-PGE₁, during intravenous administration of 20 pig, 40pig or 80 pig PGE₁ over a period of 60 min to human volunteers. It was found that levels of 15-keto-13,14- -dihydro-PGE₁, but not those of PGEx itself, increased in a dose-dependent manner. Thus, increased formation of 13,14-dihydro-PGE₁ from 15-keto- 13,14-dihydro-PGE₁ with increasing doses of PGE₁ can be expected to occur. It remains to be investigated, to which extent formation of small amounts of 13,14-dihydro-PGE₁ during intravenous infusion of PGE₁ could contribute to the therapeutic effects of PGE₁ in patients with peripheral arterial occlusive disease.

2

Treatment of hairy cell leukemia patients with 2-chloro-2'-deoxyadenosine [2-CdA]

100%

Komarnicki M., Kazmierczak M., Hansz J.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 1

3

Intraphagocytic concentrations of free and liposome ancapsulated ampicillin in sheep after intravenous infusion

84%

Yazar E., Bas A. L., Yapar K., Birdane Y. O., Elmas M., Tras B.

Bulletin of the Veterinary Institute in Puławy

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2006

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tom 50

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nr 2

4

Reduction of soluble adhesion molecules [sICAM-1, sVCAM-1, and sE-selectin] and vascular endothelial growth factor levels in serum of rheumatoid arthritis patients following multiple intravenous infusions of infliximab

84%

Klimiuk P. A., Sierakowski S., Domyslawska I., Fiedorczyk M., Chwiecko J.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

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nr 1

5

Dissociation between the effects of P1,P4-diadenosine tetraphosphate (Ap4A) on renal haemodynamics and tubular function in anaesthetized rats

84%

Jankowski M., Angielski S., Szczepanska-Konkel M.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 1

Previous studies from our laboratory have reported a marked reduction in glomerular filtration rate (GFR) and sodium reabsorption in renal proximal tubule during intravenous infusion of P1,P4-diadenosine tetraphosphate (Ap4A) at dose of 1.0 µmol/kg + 10 nmol/kg/min (i.v., injection followed by infusion) in anaesthetized Wistar rats. In the present study, the changes of GFR and urine sodium excretion were investigated in response to systemic infusion of Ap4A at different doses. Ap4A at dose of 0.1 µmol/kg + 1.0 nmol/kg/min did not change GFR and sodium urinary excretion whereas 2-fold higher dose produced significant (3.4-fold) increase in sodium excretion without changes in GFR. Significant but transient reduction in GFR by ~21% was observed during infusion of Ap4A at dose of 0.5 µmol/kg + 5.0 nmol/kg/min. Higher doses of Ap4A (1.0 µmol/kg + 10 nmol/kg/min and 2.0 µmol/kg + 20 nmol/kg/min) produced sustained reduction in GFR and marked natriuresis. Our results suggest that tubular sodium transport systems are more sensitive to Ap4A than systems involved in GFR regulation.

6

Treatment of patients with hairy cell leukemia with 2-chloro-2'-deoxyadenosine [2-CdA]

84%

Robak T., Krykowski E., Blasinska-Morawiec M., Urbanska-Rys H.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 1

7

Rozmieszczenie 'endogennego' zelaza w tkankach krolikow po dozylnym podaniu dietyloditiokarbaminianu sodowego

67%

Kucharczak E., Debowy J., Jopek Z.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2002

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tom 01

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nr 2

59-63

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The adrenal-renal vascular connection contributes to increase in renal vascular resistance during an experimental hypotension in the rat

67%

Ziecina R., Abramczyk P., Lisiecka A., Przybylski J.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 2

9

Biphasic response to lipopolysaccharide from E.coli in the isolated ventilated blood-perfused rat lung

67%

Chlopicki S., Bartus J. B., Gryglewski R. J.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 4

10

Jak założyć kateter dożylny u konia?

59%

Siwinska N., Zak A., Slowikowska M.

Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii

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2018

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tom 13

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nr 4

11

Zawartosc 'endogennego' zelaza w tkankach i plynach ustrojowych krolikow po podaniu octanu olowiu

51%

Kucharczak E., Jopek Z.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2003

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tom 02

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nr 1

11-17

Ograniczanie wyników

On the metabolism of prostaglandin E1 administered intravenously to human volunteers

Treatment of hairy cell leukemia patients with 2-chloro-2'-deoxyadenosine [2-CdA]

Intraphagocytic concentrations of free and liposome ancapsulated ampicillin in sheep after intravenous infusion

Reduction of soluble adhesion molecules [sICAM-1, sVCAM-1, and sE-selectin] and vascular endothelial growth factor levels in serum of rheumatoid arthritis patients following multiple intravenous infusions of infliximab

Dissociation between the effects of P1,P4-diadenosine tetraphosphate (Ap4A) on renal haemodynamics and tubular function in anaesthetized rats

Treatment of patients with hairy cell leukemia with 2-chloro-2'-deoxyadenosine [2-CdA]

Rozmieszczenie 'endogennego' zelaza w tkankach krolikow po dozylnym podaniu dietyloditiokarbaminianu sodowego

The adrenal-renal vascular connection contributes to increase in renal vascular resistance during an experimental hypotension in the rat

Biphasic response to lipopolysaccharide from E.coli in the isolated ventilated blood-perfused rat lung

Jak założyć kateter dożylny u konia?

Zawartosc 'endogennego' zelaza w tkankach i plynach ustrojowych krolikow po podaniu octanu olowiu