Wyniki wyszukiwania

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Overcoming the challenge; In Vivo efficacy of miltefosine for chronic cutaneous leishmaniasis

100%

Tunali V., Harman M., Cavus I., Gunduz C., Ozbilgin A., Turgay N.

Acta Parasitologica

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2021

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tom 66

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nr 2

2

Myonecrosis in a horse after an intramuscular injection of menbutone

100%

Slowikowska M., Siwinska N., Zak A., Borowicz H., Kubiak K., Niedzwiedz A.

Medycyna Weterynaryjna

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2018

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tom 74

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nr 12

Myonecrosis after intramuscular injections is not common, but may be life-threatening. This case report describes myonecrosis following an accidental intramuscular injection of menbutone. A three-year-old bay French Trotter stallion with a history of weak appetite and colic lasting ten days was treated by a field veterinarian. During the course of treatment, he was given paraffin oil and antihelminthics orally, antispasmodics, analgesics, steroids and antibiotics intravenously, as well as choleretics intramuscularly. The horse was apathetic and weak with a “tucked up” abdomen and had grade 2 ataxia, according to Mayhew’s grading system. The patient had a swollen neck on both sides and a swelling of the right front limb and the carpal area of the left front limb. The neck edema was painful and warm. The neck area was prepared and punctured; a malodorous fluid was obtained for cytology. In the material obtained, there were anaerobic rod bacteria diagnosed as Clostridium spp. Surgical fenestration and debridement were performed. The wounds were cleaned every day. The horse was given antibiotics, nonsteroidal antinflammatory drugs, fluids and gastroprotectives. After five weeks of intensive care, the condition of the horse stabilized, and significant improvement was observed. Myonecrosis may be a rare life-threatening complication following intramuscular injections or wound contamination. To the authors’ best knowledge, this is the first published report of myonecrosis after menbutone injections in the horse.

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Pharmacokinetics of tramadol and metabolites after injective administrations in dogs

84%

Giorgi M., Del Carlo S., Lebkowska-Wieruszewska B., Kowalski C. J., Saccomanni G.

Polish Journal of Veterinary Sciences

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2010

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tom 13

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nr 4

The aim of this study was to determine the pharmacokinetics of tramadol and its main metabolites after IV and IM injections. The pharmacokinetic cross-over study was carried out on 6 healthy male beagle dogs. Tramadol was administered by intravenous (IV) and intramuscular (IM) injection at 4 mg/kg. Tramadol and its main metabolites O-desmethyl-tramadol (M1), N-,N-didesmethyl-tramadol (M2) and N-,O-didesmethyl-tramadol (M5) concentrations were measured in plasma samples by a HPLC coupled with fluorimetric detection; pharmacokinetic evaluations were carried out with a compartmental and non-compartmental model for tramadol and its metabolites, respectively. The bioavailability of the drug, ranging between 84-102% (mean 92%), was within the generally accepted values for a positive bioequivalence decision of (80-125%). After the IM injection the mean plasma drug concentration peak was reached after a Tmax of 0.34 h with a Cmax of 2.52 μg/mL. No therapeutic relevant differences were observed between IM and IV administration. The minimal effective plasma concentration was reached after a few minutes and maintained for about 6-7 h in both administrations. M1 plasma concentration was low and the amounts of the other metabolites produced were analogous in both routes of administration. In conclusion, tramadol was rapidly and almost completely absorbed after IM administration and its systemic availability was equivalent to the IV injection. The different onset time and duration of action observed were very small and probably therapeutically irrelevant. The IM injection is a useful alternative to IV injection in the dog.

4

Current status and future perspectives of DNA vaccine delivery by attenuated intracellular bacteria

84%

Dietrich G.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

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nr 3

5

Próba leczenia zanokcicy owiec przy użyciu tlenku cynku

67%

Brzeski W., Depta A., Bronicki M.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1990

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tom 19

6

Changes in caveolin-1, caveolin-3 and vascular endothelial growth factor expression and protein content after botulinum toxin A injection in the right masseter muscle of dystrophin deficient (mdx-) mice

67%

Botzenhart U. U., Vaal V., Rentzsch I., Gredes T., Gedrange T., Kunert-Keil

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 2

7

Skeletal muscle-derived fibroblast-like cells fail to enable HeLa cells to induce bone in the murine kidney

67%

Wlodarski K.

Folia Biologica

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2012

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tom 60

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nr 1-2

8

Measurement of occlusal forces in the therapy of functional disorders with the use of botulinum toxin type A

67%

Pihut M., Wisniewska G., Majewski P., Gronkiewicz K., Majewski S.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 8

113-116

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The effect of intramuscular injections of boar pheromone 5 alpha-androstenol on the hormonal regulation of the estrous cycle in hypoosmatic gilts

67%

Stefanczyk-Krzymowska S., Wasowska B., Skipor J.

Polish Journal of Veterinary Sciences

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2005

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tom 08

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nr 2

10

Effects of immunomodulator FK-156 applied in lambs during the postnatal life

51%

Czarnecki A., Rybka A., Studzinski T., Winiarczyk S.

Advances in Agricultural Sciences

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1992

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tom 01

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nr 1

11

Wpływ różnych metod szczepień przeciw rzekomemu pomorowi drobiu na kształtowanie się poziomu przeciwciał u kur niosek utrzymywanych systemem klatkowym

43%

Janowska I., Kolodziej H., Krasnodebska-Depta A., Koncicki A., Matuszewska E.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1990

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tom 19

12

Badania nad wplywem ACTH na wydajnosc mleczna i sklad mleka krow

43%

Zdunczyk S., Janowski T., Ras A.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1995

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tom 22

11-16

Badania przeprowadzono na 5 krowach, które otrzymały 6 domięśniowych iniekcji 200 j.m. ACTH w odstępach 6 godzin. W okresie podawania ACTH stwierdzono wzrost koncentracji kortyzolu we krwi z 13.52 ± 2.48 nmol/l do 169.74 ±14.94 nmol/l. Wykazano, że pobudzenie kory nadnerczy może być przyczyną zmniejszenia wydajności mlecznej, wzrostu liczby komórek w mleku oraz zmian w składzie mleka.

Ograniczanie wyników

Overcoming the challenge; In Vivo efficacy of miltefosine for chronic cutaneous leishmaniasis

Myonecrosis in a horse after an intramuscular injection of menbutone

Pharmacokinetics of tramadol and metabolites after injective administrations in dogs

Current status and future perspectives of DNA vaccine delivery by attenuated intracellular bacteria

Próba leczenia zanokcicy owiec przy użyciu tlenku cynku

Changes in caveolin-1, caveolin-3 and vascular endothelial growth factor expression and protein content after botulinum toxin A injection in the right masseter muscle of dystrophin deficient (mdx-) mice

Skeletal muscle-derived fibroblast-like cells fail to enable HeLa cells to induce bone in the murine kidney

Measurement of occlusal forces in the therapy of functional disorders with the use of botulinum toxin type A

The effect of intramuscular injections of boar pheromone 5 alpha-androstenol on the hormonal regulation of the estrous cycle in hypoosmatic gilts

Effects of immunomodulator FK-156 applied in lambs during the postnatal life

Wpływ różnych metod szczepień przeciw rzekomemu pomorowi drobiu na kształtowanie się poziomu przeciwciał u kur niosek utrzymywanych systemem klatkowym

Badania nad wplywem ACTH na wydajnosc mleczna i sklad mleka krow