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1

Evidence of interstitial Cajal-like cells in the human gallbladder

100%
Pasternak A., Gajda M., Gil K., Matyja A., Tomaszewski K. A., Walocha J. A., Kulig J., Thor P.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 4
2

Histomorphology of prepuberal ovaries in the South American fur seal [Arctocephalus australis Zimmerman, 1783]

100%
Katz H., Perez W., Bielli A., Chavez R.
Folia Morphologica
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2009
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tom 68
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nr 4
277-286
The South American fur seal reproductive histophysiology is scarcely described. This study provides a histological description of prepuberal South American fur seal (Arctocephalus australis) ovaries as well as three-dimensional reconstructions of subcapsular crypts and primordial follicles. Ovaries from fresh dead animals were processed for histology and sliced into serial sections. A portion of the superficial cortex was photographed, and the images were processed using BioVis3d software in order to generate 3-dimensional reconstructions. A. australis prepuberal ovaries conform to the basic structure of pinnipedian species, with a subcapsular crypts system made up of interconnecting cisternae and tubules with multiple openings to the surface. Generally, the primordial follicles were arranged in a monolayer beneath the tunica albuginea and were closely associated with subcapsular crypts. The large number of interstitial cells distributed throughout the cortex was the main histological feature in comparison with previous reports in other seals. Three-dimensional reconstructions modelled the subcapsular crypts microarchitecture and showed the close spatial relationship between the crypts and the primordial follicles. Despite the fact that the general ovarian histological structure was similar to that of other pinnipeds, the large number of interstitial cells is a distinctive feature that raises the question about the origin and function in A. australis with regard to the steroidogenic activity reported in other seal species. (Folia Morphol 2009; 68, 4: 277–286)
3
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Loss of interstitial cells of Cajal after pulsating electromagnetic field (PEMF) in gastrointestinal tract of the rats

100%
Kaszuba-Zwoinska J., Gil K., Ziomber A., Zaraska W., Pawlicki R., Krolczyk G., Matyja A., Thor P. J.
Journal of Physiology and Pharmacology
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2005
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tom 56
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nr 3
Exposure to the magnetic field has remarkably increased lately due to fast urbanization and widely available magnetic field in diagnosis and treatment. However, biological effects of the magnetic field are not well recognized. The myoelectric activity recorded from the gastrointestinal and urinary systems is generated by specialized electrically active cells called interstitial cells of Cajal (ICCs). Thus it seems rational that ICC have significant vulnerability to physical factors like an electromagnetic field. The aim of this study was to evaluate the influence of pulsating electromagnetic field (PEMF) (frequency 10 kHz, 30ms, 300 µT burst, with frequency 1Hz) on ICCs density in the rat gastrointestinal tract. Rats were divided into two groups (n=32). The first group was exposed to PEMF continuously for 1, 2, 3, and 4 weeks (n = 16), and the second group (n=16) served as a control. Tissue samples of the rat stomach, duodenum and proximal colon were fixed and paraffin embedded. The tangential sections of 5µm thickness were stained immunohistochemically with anti-c-Kit (sc-168) antibody and visualized finally by DAB as chromogen (brown end product). C-Kit positive branched ICC-like cells were detected under the light microscope, distinguished from the c-kit-negative non-branched smooth muscle cells and from the c-kit positive but non-branched mast cells and quantitatively analyzed by MultiScan computer program. Apoptosis detection was performed with rabbit anti-Bax polyclonal antibody (Calbiochem, Germany) and LSABTM 2 visualization system. The surface of c-Kit immunopositive cells decreased after exposure to PEMF in each part of the gastrointestinal tract. Reduced density of ICCs was related to exposure time. The most sensitive to PEMF were ICCs in the fundus of the stomach and in the duodenum, less sensitive were ICCs in the colon and pacemaker areas of the stomach. No marked changes in ICC density in the pyloric part of the stomach were observed. We demonstrate that the PEMF induced apoptosis dependent decrease in ICC expression.
4
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Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease

100%
Banach T., Zurowski D., Gil K., Krygowska-Wajs A., Marszalek A., Thor P. J.
Journal of Physiology and Pharmacology
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2006
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tom 57
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nr 2
Gastrointestinal dysmotility in Parkinson's disease (PD) has been attributed in part to peripheral neurotoxine action. Our purpose was the evaluation of the salsolinol effect on intramuscular interstitial cells of Cajal (ICC), duodenal myoelectrical activity (DMA) and vagal afferent activity (VAA) in rats with experimental PD. Twenty rats were divided into 2 equal groups. Experimental PD was produced in one group by 3 weeks of the intraperitoneal salsolinol injections (50 mg/kg/day), whereas the 2-nd group served as control. DMA and VAA were recorded in both groups during fasting and stepwise - gastric distension (GD) of 10 ml. Subsequently fragments of duodenum were removed and intramuscular ICC were assessed as c-Kit antigen percentage in the duodenal muscular zone. Analyses of the fasting DMA and VAA recordings didn't reveal differences between the compared groups. During GD increase of DMA dominant frequency (p=0.04) and VAA frequency (p<0.01) was observed in the controls whereas in the salsolinol group both parameters remained unchanged. Image analysis of duodenum revealed decreased c-Kit expression in the salsolinol-injected animals (p=0.05). The results of our study may suggest the direct effect of salsolinol on both ICC and neuronal pathways of gastro-duodenal reflexes.
5

Interstitial cells of Cajal: is their role in gastrointestinal function in view of therapeutic perspectives underestimated or exaggerated?

100%
Timmermans J. P.
Folia Morphologica
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2001
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tom 60
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nr 1
This manuscript reviews the current views on morphology and function of the distinct subpopulations of interstitial cells of Cajal (ICC) in the digestive tract and their interrelationships with surrounding cells. Three different functions have been postulated so far, i.e. a pacemaker role, a mediator in enteric excitatory and inhibitory neurotransmission and a mechanosensor. Attention will also be paid to the interstitial cells of Cajal and their possible involvement in pathophysiological conditions. Finally, perspectives for interstitial cells of Cajal as targets for therapeutic intervention will be discussed.
6
Content available remote

The vagal afferents discharge and myoelectrical activity in the gastric hyperalgesia model in rats

80%
Krolczyk G., Gil K., Zurowski D., Jung A., Thor P. J.
Journal of Physiology and Pharmacology
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2008
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tom 59
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nr 4
707-716
A long term exposure of the gastric mucosa to inflammatory factors is suspected to alter the normal stomach motility. The consequence of it is an abnormal sensomotor response to food causing dyspeptic symptoms. Our study aimed to investigate the vagal afferents activity and the gastro-duodenal slow wave response to the mild gastric mucosa inflammation in rats. The gastric mucosal inflammation was induced by addition iodoacetamide to drinking water for 5 days. The gastro-duodenal slow wave, vagal nerve recordings and the gastric mucosa examination were performed on 6th day. The iodoacetamide irritated gastric mucosa presented the minimal inflammatory infiltration with mast cells. The vagal afferent activity was significantly increased after iodoacetamide treatment from 0.3 ± 0.1 to 1.9 ± 0.58 Hz, (p<0.05). The gastric slow wave accurate frequencies extracted from the fast Fourier transform spectra accelerated from 0.08 ± 0.01 to 0.1 ± 0.02 Hz (p<0.05). The duodenal frequencies remained unchanged (from 0.64 ± 0.02 to 0.59 ± 0.1 Hz). These results suggest that mild gastric mucosa irritation sensitizes vagal afferents and alters gastric but not duodenal pacemaker activity which may contribute to dyspeptic sensations.
7

Ultrastructure of the vitellarium in the digeneans Phyllodistomum angulatum (Plagiorchiida, Gorgoderidae) and Azygia lucii (Strigeida, Azygiidae)

80%
Poddubnaya L. G., Brunanska M., Swiderski Z., Gibson D. I.
Acta Parasitologica
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2012
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tom 57
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nr 3
Fine structural features of the vitellarium of two digeneans, Phyllodistomum angulatum and Azygia lucii, are documented and compared with those of other digenean species. The cytodifferentiation of immature vitelline cells (vitellocytes) assumes the production and subsequent accumulation in their cytoplasm of several inclusions. Mature vitelline cells of P. angulatum are characterized by the presence of vitelline clusters (∼2.7 μm in diameter, with ∼100 vitelline globules of ∼0.35 μm in diameter) and osmiophobic, saturated lipid droplets (∼2-3 μm in diameter), and in A. lucii vitelline clusters of the same diameter include much fewer vitelline globules (∼50 globules of ∼0.5 μm in diameter), osmiophilic lipid droplets and α-glycogen. In both P. angulatum and A. lucii, interstitial cells are also present within the vitellarium. Two types of contact sites (septate and tight junctions) between adjoining interstitial cells also occur in both digenean species. Judging from the present and previous ultrastructural studies, it is suggested that there are three potential discriminatory characters of the digenean vitellarium (the number of different types of cell components within the vitellarium, the presence and type of junctional complexes between these cells, and the isolation of the vitellarium from the surrounding tissue) which may prove useful for a better understanding of the biology and evolutionary history of the different digenean groups.
8

Different distribution of c-kit positive interstitial cells of Cajal-like in children’s urinary bladders

80%
Piaseczna-Piotrowska A. M., Dzieniecka M., Kulig A., Danilewicz M., Chilarski A.
Folia Histochemica et Cytobiologica
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2011
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tom 49
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nr 3
9

Parallel manifestation of various types of tumours in canine testes

80%
Nowaczyk R., Nowak M., Madej J. P.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
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2007
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tom 10
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nr 3
10
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Cycle dependent LH-hCG receptor gene expression in porcine nongonadal reproductive tissues

80%
Derecka K., Pietila E. M., Rajaniemi H. J., Ziecik A. J.
Journal of Physiology and Pharmacology
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1995
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tom 46
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nr 1
11
Content available remote

Physiological and morphological effects of long-term vagal stimulation in diet induced obesity in rats

71%
Gil K., Bugajski A., Kurnik M., Zaraska W., Thor P.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 3
61-66
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