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1
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Sleep quality mediates the relationship between risk of obstructive sleep apnea and acute stress in young adults

100%
Aggarwal K., Akhtar N., Mallick H.
Journal of Physiology and Pharmacology
|
2021
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tom 72
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nr 1
2
Content available remote

Intermittent hypoxia: mechanisms of action and some applications to bronchial asthma treatment

100%
Serebrovskaya T. V., Swanson R. J., Kolesnikova E. E.
Journal of Physiology and Pharmacology. Supplement
|
2003
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tom 54
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nr 1
35-41
Being essentially cut off from the global scientific community, Ukrainian and Russian scientists have developed a new concept for the beneficial use of adaptation to artificial intermittent hypoxia in treating of many diseases. The basic mechanisms underlying intermittent hypoxic training were elaborated mainly in three areas: regulation of respiration, free radical production and mitochondrial respiration. Twenty-year experience of the application of intermittent hypoxic therapy for the treatment of chronic obstructive bronchitis and bronchial asthma allows affirming that the adaptation to this kind of hypoxia causes a significant improvement of the clinical picture or even a complete recovery. The absence of negative side effects, typically observed during drug therapy, and the stimulation of organism’s general, nonspecific resistance, makes the hypoxic therapy a treatment with a future. A special note is devoted to the use of intermittent hypoxic training in industrial health care for the purpose of prophylaxis and treatment of professional diseases.
3
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Statistical evaluation of ventilatory patterns in response to intermittent hypoxia in the rabbit

86%
Sokolowska B., Jozwik A.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 4
203-207
In the present study we investigated whether classical or non-classical statistical methods might be useful in the diagnosis of early changes evoked by intermittent hypoxia (IH) in an experimental model. The experiments were carried out in anesthetized, spontaneously breathing rabbits. IH consisted of 5 cycles of breathing 14% O2 in N2 for 1 min interspersed with 3 min normoxic intervals. The following ventilatory variables were evaluated: frequency breathing, tidal volume, and minute ventilation. The results indicate that IH had a progressively stimulatory effect on the baseline ventilation and on the hypoxic ventilatory responses. Further, the algorithms of the pattern recognition theory might be a suitable tool for the recognition of early ventilatory effects of recurrent hypoxic events in the IH model. The recognition of IH states may be useful in clinical and sports medicine.
4
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Distinguishing the strength of hypoxic stimulus in intermittent hypoxia

72%
Sokolowska B., Jozwik A.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
5
Content available remote

Disturbed angiogenic activity in sera from obstructive sleep apnea patients

72%
Chorostowska-Wynimko J., Radomska D., Plywaczewski R., Jonczak L., Stepniewska A., Gorecka D., Skopinska-Rozewska E.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 4
71-77
It is increasingly recognized that obstructive sleep apnea (OSA) syndrome is a systematic rather than local disorder. There is also growing evidence that apart from the syndrome's major features: intermittent hypoxia and sleep fragmentation, functional activity of the immune system is altered in OSA patients, with several cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) taking active part in sleep regulation. Little is known about the effects exerted by chronic intermittent hypoxia combined with persistent pro-inflammatory activity of the immune system on the vascular micro milieu in OSA. In this study we attempted to confirm the hypothesized imbalance between pro- and anti-angiogenic factors by evaluating direct and indirect angiogenic activity of OSA patients' sera in the in vivo serum-induced angiogenesis (SIA) and leukocyte-induced (LIA) assays, respectively, in mice. Both tests revealed significantly inhibited angiogenic activity of OSA patients' sera compared with healthy controls (P<0.001). Moreover, differences related to the subject’s weight regarding in the mean number of newly-formed vessels were observed with a significantly greater inhibition in the normal-weighing apneic subjects than in the overweight or obese ones (P<0.01). The angiogenesis inhibition index was positively related to the serum IL-6 level (r=0.35; P<0.05) in the OSA group, but not to TNF-alpha, fasting serum leptin, or OSA syndrome severity as assessed by the AHI index. Our results demonstrate that OSA is accompanied by disturbed serum angiogenic activity, apparently resulting from an imbalance between pro- and anti-angiogenic factors, some of them being produced by the adipose tissue. The disordered angiogenic activity might be related to the pathophysiology of OSA and should be considered an important causative factor for the increased prevalence of cardiovascular diseases in OSA patients.
6
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Aging and expression of heme oxygenase-1 and endothelin-1 in the rat carotid body after chronic hypoxia

58%
Di Giulio C., Verratti V., Artese L., Petruccelli G., Walski M., Pokorski M.
Journal of Physiology and Pharmacology. Supplement
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2009
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tom 60
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nr 5
7
Content available remote

Electroencephalographic and respiratory activities during acute intermittent hypoxia in anesthetized rats

58%
Budzinska K., Ilasz R.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
|
nr 5
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