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  1. 12 Archivum Immunologiae et Therapiae Experimentalis

  2. 9 Journal of Physiology and Pharmacology

  3. 8 Journal of Physiology and Pharmacology. Supplement

  4. 4 Cellular and Molecular Biology Letters

  5. 2 Folia Histochemica et Cytobiologica

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  1. 3 Dzierzewicz Z.

  2. 3 Konturek P. C.

  3. 3 Orchel A.

  4. 3 Weglarz L.

  5. 2 Brzozowski T.

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  1. 1 2021

  2. 1 2020

  3. 1 2018

  4. 2 2017

  5. 1 2016

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1

Elastase, alpha1-proteinase inhibitor, and interleukin-8 in children and young adults with end-stage kidney disease undergoing continuous ambulatory peritoneal dialysis

100%
Polanska B., Augustyniak D., Makulska I., Niemczuk M., Jankowski A., Zwolinska D.
Archivum Immunologiae et Therapiae Experimentalis
|
2014
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tom 62
|
nr 3
2
Content available remote

Influence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cells

100%
Radomska-Lesniewska D. M., Sadowska A. M., Van Overveld F. J., Demkow U., Zielinski J., De Backer W. A.
Journal of Physiology and Pharmacology. Supplement
|
2006
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tom 57
|
nr 4
325-334
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation. The initial step in the inflammatory process is overexpression of adhesion molecules, which leads to excessive transmigration of neutrophils. One of these adhesion molecules is ICAM-1 which is elevated in COPD patients. In this study we evaluated the influence of N-acetylcysteine (NAC) (0.01 mM-30 mM) on the cytokine-induced (TNF-alphalpha/IL-1ß) expression of the ICAM-1 adhesion molecule and on IL-8 release in endothelial (ECV-304) and bronchial epithelial (H292) cell lines. The methodology used consisted of immunochemistry for the assessment of surface ICAM-1 and ELISA method for that of soluble ICAM-1 and IL-8. NAC inhibited the TNF-alphalpha/IL-1ß-stimulated ICAM-1 expression and IL-8 release from both cell lines in a concentration dependent manner. The most effective concentrations were 30 mM and 20 mM (99 and 90% inhibition respectively, P<0.01). We conclude that NAC is an effective inhibitor of TNF-alphalpha/IL-1ß- stimulated ICAM-1 and IL-8 release in endothelial and epithelial cells. This fact highlights the anti-inflammatory potential of NAC in COPD.
3

IP6 modulates interleukin-8 secretion in colon epithelial cells by influencing various signalling pathways

100%
Weglarz L., Wawszczyk J., Orchel A., Dzierzewicz Z.
Cellular and Molecular Biology Letters
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2005
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tom 10
|
nr Suppl.2
4

Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-alpha in human dermal microvascular endothelial cells

84%
Del Socorro Pina-Canseco M., Paez-Arenas A., Masso F., Perez-Campos E., Martinez-Cruz R., Hernandez-Cruz P., Majluf-Cruz A., Martinez-Cruz M., Perez-Campos Mayoral L., Perez-Santiago A. D., Zenteno E.
Folia Histochemica et Cytobiologica
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2012
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tom 50
|
nr 3
5

Prolonged treatment with inhaled corticosteroids does not normalize high activity of matrix metalloproteinase-9 in exhaled breath condensates of children with asthma

84%
Grzela K., Zagorska W., Krejner A., Litwiniuk M., Zawadzka-Krajewska A., Banaszkiewicz A., Kulus M., Grzela T.
Archivum Immunologiae et Therapiae Experimentalis
|
2015
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tom 63
|
nr 3
6
Content available remote

The role of local and systemic cytokines in patients infected with Clostridium difficile

84%
Czepiel J., Biesiada G., Brzozowski T., Ptak-Belowska A., Perucki W., Birczynska M., Jurczyszyn A., Strzalka M., Targosz A., Garlicki A.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 5
7

Exhaled IL-8 in systemic lupus erythematosus with and without pulmonary fibrosis

84%
Nielepkowicz-Gozdzinska A., Fendler W., Robak E., Kulczycka-Siennicka L., Gorski P., Pietras T., Brzezianska E., Antczak A.
Archivum Immunologiae et Therapiae Experimentalis
|
2014
|
tom 62
|
nr 3
8
Content available remote

Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury

84%
Kim E. K., Cho J. H., Jeong A. R., Kim E. J., Park D. K., Kwon K. A., Chung J. W., Kim K. O., Kim J. H., Kim J. H., Kim Y. J.
Journal of Physiology and Pharmacology
|
2017
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tom 68
|
nr 1
9

Host response to the presence of Helicobacter spp. DNA in the liver of patients with chronic liver diseases

84%
Rybicka M., Nakonieczna J., Stalke P., Bielawski K. P.
Polish Journal of Microbiology
|
2011
|
tom 60
|
nr 2
Literature data indicate an association between the presence of Helicobacter spp. in the liver and the development of hepatocellular carcinoma (HCC). However, the role of H. pylori infections in chronic liver diseases (CLD) remains controversial. The aim of this study was to detect Helicobacter spp. DNA in patients with CLD, and to investigate the host response to the presence of the bacterium in the liver. Helicobacter spp. DNA was detected in 59% samples. H.pylori was the most prevalent species (94%). We estimated the expression level of IL-1 and IL-8 genes. The presence of Helicobacter spp. did not have a significant effect on the gene expression of IL-8 and IL-1.
10
Content available remote

Inhibitory effect of alpha-lipoic acid on mitochondrial dysfunction and interleukin-8 expression in interleukin-1beta-stimulated ataxia telangiectasia fibroblasts

84%
Yoon J., Lee H., Lim J. W., Kim H.
Journal of Physiology and Pharmacology
|
2020
|
tom 71
|
nr 1
11

Selected clinical features fail to predict inflammatory gene expressions for TNF‑alpha, TNFR1, NSMAF, Casp3 and IL‑8 in tendons of patients with rotator cuff tendinopathy

84%
Struzik S., Czarkowska‑Paczek B., Wyczalkowska‑Tomasik A., Maldyk P., Paczek L.
Archivum Immunologiae et Therapiae Experimentalis
|
2021
|
tom 69
|
nr 1
12

Desulfovibrio desulfuricans lipopolysaccharides induce endothelial cell IL-6 and IL-8 secretion and E-selectin and VCAM-1 expression

84%
Weglarz L., Dzierzewicz Z., Skop B., Orchel A., Parfiniewicz B., Wisniowska B., Swiatkowska L., Wilczok T.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 4
The aim of this study was to determine whether Desulfovibrio desulfuricans-derived LPS stimulate the release of IL-6 and IL-8 from ECs and the expression of their adhesion molecules at the transcriptional level. Confluent monolayers of HUVEC were incubated in the absence or presence of 20 μg/ml and 60 μg/ml LPSs derived from the DdT and DdA bacterial strains. Also, the simultaneous stimulation of cells with LPSs and IL-1β was evaluated. The levels of cytokines released were measured using ELISA. LPS-activated HUVEC increased the secretion of both IL-6 and IL-8, which was not LPS dose dependent. The expression of E-selectin and VCAM-1 was assessed by TR-PCR. The transcripts were detectable at all the concentrations (20, 40, 60 μg/ml) of LPSs used. These results suggest that D. desulfuricans LPS may activate immune functions in endothelial cells and influence the inflammatory response during bacteremia caused by these bacteria.
13

High level expression of STAG1-PMEPA1 in an androgen-independent prostate cancer PC3 subclone

84%
Hirokawa Y. S., Takagi A., Uchida K., Kozuka Y., Yoneda M., Watanabe M., Shiraishi T.
Cellular and Molecular Biology Letters
|
2007
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tom 12
|
nr 3
In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.
14
Content available remote

Glycoconjugates with NeuAc-NeuAc-Gal-Glc are more effective at preventing adhesion of Helicobacter pylori to gastric epithelial cells than glycoconjugates with NeuAc-Gal-Glc

84%
Hata Y., Murakami M., Okabe S.
Journal of Physiology and Pharmacology
|
2004
|
tom 55
|
nr 3
Helicobacter pylori (H. pylori) adheres to human gastric epithelial cells, eliciting various gastroduodenal diseases. Gangliosides play a critical role in bacterial adhesion to cell surfaces. The present study examined how residues of gangliosides are important for inhibition of adhesion of H. pylori to MKN-45 cells. We measured adhesion or detachment effects of gangliosides on the interaction between MKN-45 cells and H. pylori, as well as interleukin-8 production. Among the gangliosides, O-Ac-GD3, GT1b, GD1a, GD1b, GT1a, and GD3 had potent dose dependent inhibitory effects on adhesion of H. pylori to MKN-45 cells, interleukin-8 production, and vacuole formation induced by H. pylori toxin binding to Vero cells. GD3 also accelerated bacterial detachment of MKN-45 cells with adherent H. pylori in a dose dependent manner. Such results strongly suggest that the mechanism involved in the inhibition of H. pylori adhesion is mediated by the variations of the residues of the NeuAc-NeuAc-Gal-Glc chain of gangliosides. NeuAc-NeuAc-Gal-Glc exhibits a more inhibitory effect on adhesion than the NeuAc-Gal-Glc chain. Such gangioside and oligosaccrharide sequences appear to have therapeutic importance for prevention of H. pylori adhesion, as well as reduction of both inflammation and gastric mucosal injuries.
15

The neutrophil-activating peptide 1-interleukin 8, a novel neutrophil chemotactic cytokine

84%
Schroder J. M.
Archivum Immunologiae et Therapiae Experimentalis
|
1992
|
tom 40
|
nr 1
16
Content available remote

Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and STNFR55-TNFR75 in plasma of patients with acute pancreatitis

84%
Naskalski J. W., Kusnierz-Cabala B., Panek J., Kedra B.
Journal of Physiology and Pharmacology
|
2003
|
tom 54
|
nr 3
Plasma pancreatic-type Poly-C specific ribonuclease (P-RNase) - enzyme activity increases in patients with acute pancreatitis (AP) who develop pancreatic necrosis and severe disease course. It is considered as a marker of pancreatic tissue destruction. The aim of this study was to estimate interrelations between major inflammatory cytokines such as: interleukin 6 (IL-6), interleukin 8 (IL-8) and tumor necrosis factor soluble receptors: sTNFR55 and sTNFR75 output, and plasma P-RNase activity. The study was carried out in a group of 56 patients with AP, where 20 developed pancreatic necrosis. It was found that serum P-RNase concentration and levels of all studied inflammatory cytokines significantly increase already in the first day from diagnose of the disease (2,5 folds for P-RNase, 20 for IL-8, about 200 for IL-6 and 1,5 for receptors, respectively). In the first day from admission to hospital, P-RNase activity significantly correlated with plasma concentration of studied inflammatory cytokines. The most pronounced correlation was found for P-RNase and IL-6 in days 1-4 from diagnose, manifested by Pearson correlation r coefficients amounting to 0,86; 0,79; 0,60 and 0,57 respectively (p<0,001). Dividing the studied AP patients into two groups, varying in severity of disease a significant differences in P-RNase and IL-6, IL-8 and sTNFR55/sTNFR75 were found. In patients with acute necrotizing pancreatitis P-RNase significantly correlate with levels of major inflammatory cytokines. Carried out studies suggest that activity of P-RNase reflects severity of inflammatory reaction, which is dependent on development of pancreatic injury and tissue necrosis in AP.
17

Toll-like receptors’ pathway disturbances are associated with increased susceptibility to infections in humans

67%
Frazao J. B., Errante P. R., Condino-Neto A.
Archivum Immunologiae et Therapiae Experimentalis
|
2013
|
tom 61
|
nr 6
18
Content available remote

IL-6 and IL-8 responses of colorectal cancer in vivo and in vitro cancer cells subjected to simvastatin

67%
Malicki S., Winiarski M., Matlok M., Kostarczyk W., Guzdek A., Konturek P. C.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 4
141-146
Recent investigations suggest that proinflammatory cytokines such as IL-6 and IL-8 are involved in the development of colorectal cancer (CRC), whereas statins, primarily used to decrease high levels of blood cholesterol, exhibit pleiotropic effects on carcinogenesis. In the present study we compared the expression of IL-8 and IL-6 in tissue samples of tumor and adjacent normal colon mucosa obtained from patients with advanced colorectal cancer (CRC). The analysis of mRNAs expression for these proinflammatory cytokines determined by RT-PCR showed a higher level of IL-8-mRNA in tumor tissue than in normal mucosa, while IL-6 was similarly expressed in tumor and normal tissue. The mean values of serum levels of both IL-6 and IL-8 were significantly higher in CRC patients than in healthy volunteers. Surgical removal of the tumor resulted in a prompt decrease of serum level of IL-8 already on the third day, whereas IL-6 level was transiently increased to become lower only after 7-10 days. Treatment of CRC with simvastatin (80 mg/day for 14 days) led to a significant decrease of serum IL-6, while the IL-8 level was less affected. The in vitro experiments on colorectal cancer-derived cell lines (HT-29 and Caco-2) demonstrated that application of simvastatin decreased generation of both IL-6 and IL-8. The differences in response of serum levels of IL-6 and IL-8 after tumor removal and treatment with simvastatin are novel observations suggesting distinct pathological roles of the two cytokines in CRC development. We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines.
19

Potential roles of the NFkappaB and glutathione pathways in mature human erythrocytes

67%
Ghashghaeinia M., Toulany M., Saki M., Rodemann H. P., Mrowietz U., Lang F., Wieder T.
Cellular and Molecular Biology Letters
|
2012
|
tom 17
|
nr 1
Anucleated erythrocytes were long considered as oxygen-transporting cells with limited regulatory functions. Components of different nuclear signaling pathways have not been investigated in those cells, yet. Surprisingly, we repeatedly found significant amounts of transcription factors in purified erythrocyte preparations, i.e. nuclear factor κB (NFκB), and major components of the canonical NFκB signaling pathway. To investigate the functional role of NFκB signaling, the effects of the preclinical compounds Bay 11-7082 and parthenolide on the survival of highly purified erythrocytes were investigated. Interestingly, both inhibitors of the NFκB pathway triggered erythrocyte programmed cell death as demonstrated by enhanced phospholipid scrambling (phosphatidylserine exposure) and cell shrinkage. Anucleated erythrocytes are an ideal cellular model allowing the study of nongenomic mechanisms contributing to suicidal cell death. As NFκB inhibitors might also interfere with the anti-oxidative defense systems of the cell, we measured the levels of reduced glutathione (GSH) after challenge with the inhibitors. Indeed, incubation of erythrocytes with Bay 11-7082 clearly decreased erythrocyte GSH levels. In conclusion, the pharmacological inhibitors of the NFκB pathway Bay 11-7082 and parthenolide interfere with the survival of erythrocytes involving mechanisms other than disruption of NFκB-dependent gene expression. Besides affecting erythrocyte survival, NFκB inhibition and induction of erythrocyte phosphatidylserine exposure may influence blood clotting. Future studies will be aimed at discriminating between NFκB-dependent and NFκB-independent GSH-mediated effects of Bay 11-7082 and parthenolide on erythrocyte death.
20
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Content available

Associations between interleukin-8 receptor (CXCR1) and interleukin-6 (IL6) polymorphism and immunity to mastitis in the Black-and-White variety of Polish Holstein-Friesian cows

67%
Stanislawczyk A., Wojdak-Maksymiec K.
Acta Scientiarum Polonorum. Zootechnica
|
2018
|
tom 17
|
nr 3
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