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1
Content available remote

Increased levels of interleukin-12 and interleukin-18 in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis

100%
Mroz R. M., Korniluk M., Stasiak-Barmuta A., Chyczewska E.
Journal of Physiology and Pharmacology. Supplement
|
2008
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tom 59
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nr 6
507-513
2

Cytokine-based immunotherapy of allergic disease

100%
Lewkowich I. P., HayGlass K. T.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
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tom 49
|
nr 4
3

Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils

100%
Jablonska E., Marcinczyk M., Jablonski J.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
|
tom 54
|
nr 2
4
Content available remote

Upregulation of Th1 cytokine profile in bronchoalveolar lavage fluid of patients with hypersensitivity pneumonitis

84%
Mroz R. M., Korniluk M., Stasiak-Barmuta A., Chyczewska E.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 6
499-505
5

Caspases as the key effectors of inflammatory responses against bacterial infection

84%
Uchiyama R., Tsutsui H.
Archivum Immunologiae et Therapiae Experimentalis
|
2015
|
tom 63
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nr 1
6
Content available remote

Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, uromodulin, and cystatin C concentrations in an experimental rat model of ascending acute kidney injury induced by pyelonephritis

84%
Skowron B., Baranowska A., Dobrek L., Ciesielczyk K., Kaszuba-Zwoinska J., Wiecek G., Malska-Wozniak A., Strus M., Gil K.
Journal of Physiology and Pharmacology
|
2018
|
tom 69
|
nr 4
7

Microvascular abnormalities in capillaroscopy correlate with higher serum IL-18 and sE-selectin levels in patients with type 1 diabetes complicated by microangiopathy

67%
Kuryliszyn-Moskal A., Dubicki A., Zarzycki W., Zonnenberg A., Gorska M.
Folia Histochemica et Cytobiologica
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2011
|
tom 49
|
nr 1
8
Content available remote

In vitro angiomodulatory activity of sera from type 2 diabetic patients with background retinopathy

67%
Chorostowska-Wynimko J., Skopinski P., Szaflik J., Partyka I., Duda-Krol B., Anuszewska E., Skopinska-Rozewska E.
Journal of Physiology and Pharmacology. Supplement
|
2005
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tom 56
|
nr 4
65-70
Diabetic retinopathy is the leading cause of adult vision loss and blindness. The most important contributors to the development of diabetic retinopathy are hyperglycemia and hypoxemia that lead to increased vasopermeability, endothelial cell proliferation, and pathological neovascularization. In our previous studies, close relationship between proangiogenic activity of sera from type 2 diabetes mellitus patients (DM2) with background retinopathy, assessed in the in vivo serum-induced mouse cutaneous test (SIA), and VEGF and IL-18 serum concentration were observed. Moreover, it was clearly shown that IGF-1 might play an important role in the negative regulation of neoangiogenesis induced by DM2 patients' sera by diminishing the VEGF stimulatory effect. To confirm the observed phenomenon we evaluated the effect of DM2 patients' sera on the in vitro proliferative activity of human endothelial cells, which is critical for the sprouting and generation of new blood capillaries. Endothelial proliferative activity was significantly higher in the presence of sera from DM2 patients than from healthy controls (P<0.001), as estimated by the MTT test. Moreover, the examined sera from DM2 patients were characterized by increased IL-18 (P<0.05), diminished IGF-1 (P<0.02), and unchanged VEGF levels compared with those in controls. In conclusion, the present study showed a strong stimulatory effect of DM2 patients' sera on the proliferation of endothelial cells, which, along with the findings of our previous studies, proves that the described phenomenon is universal and valid for both animal and human endothelium.
9

Viral modulation of cell death by inhibition of caspases

67%
Cassens U., Lewinski G., Samraj A. K., Von Bernuth H., Baust H., Khazaie K., Los M.
Archivum Immunologiae et Therapiae Experimentalis
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2003
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tom 51
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nr 1
10
Content available remote

Brain-gut and appetite regulating hormones in the control of gastric secretion and mucosal protection

59%
Konturek S. J., Brzozowski T., Konturek P. C., Schubert M. L., Pawlik W. W., Padol S., Bayner J.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
|
nr 2
The progress in basic and clinical gastrology indicates that gastric mucosal integrity represents a balance between offensive and defensive factors. The main offensive factors appear to be gastric acid and pepsin under health conditions, while the non-steroidal anti-inflammatory drugs (NSAID) and Helicobacter pylori (H. pylori), infecting this mucosa, are currently considered the most important “aggressive” factors under pathological conditions. To the list of the aggressive factors, also stress, certain cytokines (TNF-, IL-8, IL-11 and IL-18) and oxygen or nitrogen free radicals should be added. The aims of this review is the presentation of the involvement of aggressive and protective factors in the control of gastric acid secretion and appetite regulating hormones in maintaining gastric mucosal integrity and its protection against damaging factors.
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