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Involvement of Fas-FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

100%

Stassi G., Di Felice V., Todaro M., Cappello F., Zummo G., Farina F., Trucco M., De Maria R.

Archivum Immunologiae et Therapiae Experimentalis

1999

tom 47

nr 3

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Association of chosen microsatellite markers on chromosomes 10, 11p and 14q with IDDM susceptibility in the population of midwestern Poland

80%

Jungerman M., Fichna P.

Journal of Applied Genetics

1996

tom 37

nr 2

In search for new markers of insulin-dependent diabetes (IDDM) susceptibility we studied the CATT tetranucleotide repeat in intron 1 of tyrosine hydroxylase (TH) gene on chromosome lip, the CA repeat at T-cell receptor a chain (TCRA) locus on chromosome 14q and two CA repeats at D10S211 and D10S213 loci in the chromosome 10 region containing glutamic acid decarboxylase (GAD2) gene. Alleles at these microsatellite loci were identified in a population of diabetic children and unrelated healthy controls originating from Wielkopolska, a midwestern region of Poland. We found significant association of certain alleles at TH, TCRA and D10S211 loci with diabetes in the population under study. On the contrary, none of the alleles at D10S213 locus was associated with the disease. Our findings indicate that typing of microsatellite markers may represent useful additional tool for identifying individuals at high risk of developing IDDM. Regarding loci on chromosome 10 our data and data published by other authors may suggest the extistence of two separate regions of association with IDDM susceptibility on this chromosome.

Ograniczanie wyników

1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Applied Genetics

1 Cappello F.

1 De Maria R.

1 Di Felice V.

1 Farina F.

1 Fichna P.

1 Jungerman M.

1 Stassi G.

1 Todaro M.

1 Trucco M.

1 Zummo G.

1 1999

1 1996

Wyniki wyszukiwania

Involvement of Fas-FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

Association of chosen microsatellite markers on chromosomes 10, 11p and 14q with IDDM susceptibility in the population of midwestern Poland