Wyniki wyszukiwania

1

Human ventilatory efficiency and respiratory sinus arrhythmia during head-up tilt

100%

Brown S. J., Bryant M., Mundel T., Stannard S. R.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 4

771-780

Cardiac vagal withdrawal when moving from supine to an upright posture may be independent of respiratory sinus arrhythmia. Further, ventilatory efficiency of an upright lung may improve with clustering of heart beats during inhalation. We studied healthy human subjects (n=8, 6 male) during supine rest (SUP) and 80° head-up tilt (HUT). ECG and expired breath were sampled continuously to determine heart rate, mean and end-tidal (ET) fractional content (F) of O2 and CO2, tidal volume (VT) and breathing frequency (Bf). HUT increased heart rate (47±3 vs. 59±9 beats min-1, p<0.01), decreased the high frequency component of heart rate variability (8.76± vs. 7.07±1.12, p<0.05), and increased the ratio of low to high frequency components in the heart rate (0.62±0.6 vs. 1.79±2.07, p<0.05). HUT did not change VT, Bf, or minute ventilation (V'E), but decreased FCO2 (4.90±0.48 vs. 4.56±0.42 %, p<0.05) and FETCO2 (6.64±0.24 vs. 6.30±0.27 %, p<0.01). HUT increased the CO2 ventilatory equivalent (24.88±2.50 vs. 26.74±2.61, p<0.01). Mean heart rate during inhalation increased with HUT (26±3 vs. 34±6 beats min-1), with no change during exhalation. Increased clustering of heart beats during inhalation independent of a decrease in HF cardiac variability may partly offset decreases in ventilatory efficiency of an upright lung.

2

Inhaled insulin - does it become reality?

86%

Siekmeier R., Scheuch G.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

81-113

3

Systemic treatment by inhalation of macromolecules - principles, problems, and examples

86%

Siekmeier R., Scheuch G.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

53-79

4

Efficacy and safety of once or twice daily inhalation of extrafine HFA beclomethasone dipropionate in patients with mild to moderate asthma

72%

Gillissen A., Richter A., Oster H., Criee C.-P.

Journal of Physiology and Pharmacology. Supplement

|

2007

|

tom 58

|

nr 5

5

Treatment of systemic diseases by inhalation of biomolecule aerosols

72%

Siekmeier R., Scheuch G.

Journal of Physiology and Pharmacology. Supplement

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2009

|

tom 60

|

nr 5

6

Inhalation of tobramycin in patients with cystic fibrosis: comparison of two methods

72%

Dopfer R., Brand P., Mullinger B., Hunger T., Haussermann S., Meyer T., Scheuch G., Siekmeier R.

Journal of Physiology and Pharmacology. Supplement

|

2007

|

tom 58

|

nr 5

7

Tussigenic agents in the measurement of cough reflex sensitivity

72%

Pecova R., Javorkova N., Kudlicka J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

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2007

|

tom 58

|

nr 5

8

Late consequences of respiratory system burns

72%

Krzywiecki A., Ziora D., Niepsuj G., Jastrzebski D., Dworniczak S., Kozielski J.

Journal of Physiology and Pharmacology. Supplement

|

2007

|

tom 58

|

nr 5

9

The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy

72%

Brozmanova M., Plevkova J., Bartos V., Plank L., Javorka M., Tatar M.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 4

45-54

Inhalation of high concentration of oxygen produces oxidative stress in men and experimental animals. Our previous experiments showed that the cough reflex is suppressed in guinea pigs after exposure to 100% O2 for 60 hours. The aim of this study was to determine the effects of dietary antioxidant supplementation with vitamins C and E on hyperoxia-induced oxidative stress in airway and lung tissues directed on cough reflex. The experimental group (T-H, n=8) was pretreated with vitamins C (500 mg/kg) and E (300 mg/kg) for 4 weeks and subsequently exposed to 100% O2 for 60 hours. Hyperoxic group (H, n=8) received saline instead of antioxidants and then inhaled 100% O2 for 60 hours. Cough was induced by inhalation of citric acid aerosol in gradually increased concentration (0.05-1.6 M) at the end of antioxidant therapy and then at the end of exposure to 100% O2. Cough was also induced by mechanical stimulation of laryngopharyngeal (LPh) and tracheobronchial (TBr) region in anaesthetized animals just 1 hour after the end of oxygen exposure. Our results showed a tendency to a decrease in citric acid-induced cough in hyperoxic animals and an increase in animals with antioxidant therapy after hyperoxia. Antioxidant therapy significantly unblocked hyperoxia-induced down-regulation of cough (P=0.004). Significant changes also were obtained from mechanically-induced TBr cough [2.5(1-4) vs. 1.0(1-2); P<0.01] between the experimental and hyperoxic (control) animals. In conclusion, our results indicate a protective effect of antioxidant supplementation on oxidant-mediated cough depression.

10

The impact of hypertonic saline inhalation on mucociliary clearance and nasal nitric oxide

72%

Bencova A., Vidan J., Rozborilova E., Kocan I.

Journal of Physiology and Pharmacology

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2012

|

tom 63

|

nr 3

11

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Organic dust induced pulmonary disease - the role of mould derived beta-glucan

72%

Rylander R.

Annals of Agricultural and Environmental Medicine

|

2010

|

tom 17

|

nr 1

9-13

12

Mesitylene [1,3,5-trimethylbenzene] in the liver, lung, kidney, and blood and 3,5-dimethylbenzoic acid in the liver, lung, kidney and urine od rats after single and repeated inhalation exposure to mesitylene

72%

Swiercz R., Wasowicz W., Majcherek W.

Polish Journal of Environmental Studies

|

2006

|

tom 15

|

nr 3

The aim of our study was to explore the tissue distribution of 3,5-dimethylbenzene acid (3,5-DMBA) and its excretion with urine of rats and to evaluate toxicokinetics of mesitylene in blood of rats after single and repeated inhalation exposure to mesitylene vapours. Experiments were performed on male outbred IMP:WIST rats. The animals were exposed to mesitylene vapours at the target concentration of 25, 100, and 250 ppm in dynamic inhalation chambers for 6 h at single exposure and for 4 weeks (6 h/day for 5day/week) at repeated exposure. The study revealed in rats, after inhalation exposure to mesitylene, exposure-dependent increases in 3,5-DMBA tissue concentration and urinary excretion as well as enhanced mesitylene concentration in tissues and blood. After termination of exposure, mesitylene was rapidly eliminated from blood of rats. Mesitylene retention reduced in rat lungs after repeated exposure, as compared to a single exposure, was most likely the reason for its lower concentration in lungs and blood. Compared with single exposure, 3,5-DMBA concentration increased in rat lungs after repeated inhalation exposure to mesitylene at 100 and 250 ppm, and in the liver at 250 ppm, which may be associated with the induction of mesitylene-metabolizing enzymes. Mesitylene metabolism in the lungs of the rats after repeated exposure to its low concentrations probably had a significant impact on the increased urinary excretion of 3,5-DMBA.

13

Adaptable changes in rat liver microsomal enzyme activities in response to inhalation with C6-C9 hydrocarbon petroleum fraction

72%

Szutowski M. M., Ziecik W., Wiaderkiewicz R., Kaminski M.

Acta Poloniae Toxicologica

|

2001

|

tom 09

|

nr 1

14

Functional diagnosis of respiratory efficiency of cokery mill employees working in a polluted atmosphere

72%

Kolarzyk E., Stepniewski M.

Polish Journal of Environmental Studies

|

1999

|

tom 08

|

nr 4

Reaction of the airways to inhaled Berodual was evaluated in two groups of metallurgists surveilled by systematic, complex medical examinations for appx. 25 years: 31 coke oven and 31 cold-rolling mill workers. All subjects under examination were active smokers, smoking more than 20 cigarettes a day. The frequency of ventilatory disorders: central bronchi obturation, small bronchi obturation and emphysemal changes, as well as microclimatic conditions of their living places, even mean anthropometric indices were similar. The main differentiating factor was presence of air pollutants in their workshops. Employees of coke owen division were exposed to variety of noxious substances: CO, NOx, SO2, benzene, its derivatives, HCN and policyclic aromatic hydrocarbons. In cold rolling division concentration of air pollutions was much smaller and virtually devoided of BaP. As revealed by Berodual provocation test in coke owen workers irreversible obturation and fixed emphysemal changes were far more frequent than in workers of cold rolling mill performing their job in favorable microclimatic conditions.

15

Influence of xanthine derivatives on cough and airway reactivity in guinea pigs

58%

Mokry J., Nosalova G., Mokra D.

Journal of Physiology and Pharmacology. Supplement

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2009

|

tom 60

|

nr 5

16

Anticoagulative effects of the inhaled low molecular weight heparin certoparin in healthy subjects

58%

Scheuch G., Brand P., Meyer T., Herpich C., Mullinger B., Brom J., Weidinger G., Kohlhaufl M., Haussinger K., Spannagl M., Schramm W., Siekmeier R.

Journal of Physiology and Pharmacology. Supplement

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2007

|

tom 58

|

nr 5

17

Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs

58%

Brozmanova M., Plevkova J., Bartos V., Plank L., Javorka M., Masar J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

|

2007

|

tom 58

|

nr 5

18

Hydrogen gas reduces brain injury in a global cerebral ischemia model

58%

Ostrowski R. P., Mansell C., Zhang J. H.

Acta Neurobiologiae Experimentalis

|

2013

|

tom 73

|

nr 1

Transient global cerebral ischemia-reperfusion injury can occur during acute severe hypotensive states and in cardiac arrest that is followed by resuscitation. This transient reduction in perfusion causes an insult to selective hippocampal neuronal populations via an apoptotic mechanism. Hydrogen gas has a neuroprotective effect and could be used as a pharmacologic agent of beneficial effect. As such we set out in this study to describe the effect of the inhalation of 2.9% hydrogen enriched air following an ischemia-reperfusion injury. A 2-vessel occlusion model was used to induce global cerebral ischemia for 6 minutes while maintaining a hypotensive state with a mean arterial pressure of 30 mm Hg through reversible exsanguinations in male Sprague-Dawley rats (280–330 g). The study included three groups: global ischemia without treatment (GI, n=6), global ischemia with hydrogen (GI + H2, n=6 ) and sham surgery (Sham, n=6). Rats in the treatment group received 2.9% inhalational hydrogen for 1 hour starting 15 minutes following reperfusion. Neurobehavioral testing was performed on day one and T-maze testing prior to being euthanized on days 3 or 7. Treated rats demonstrated an improved outcomes in spontaneous alternations, seizure incidence and survivability. Quantitative Nissl histology and TUNEL of the CA-1 region of the hippocampus showed increased cell survival in the treatment group. We conclude that treatment with inhalational hydrogen following ischemia-reperfusion injury could be low cost method of decreasing the effects of neuronal cell death.

19

The influence of autonomic neuropathy on cough reflex sensitivity in children with diabetes mellitus type 1

58%

Varechova S., Durdik P., Cervenkova V., Ciljakova M., Banovcin P., Hanacek J.

Journal of Physiology and Pharmacology. Supplement

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2007

|

tom 58

|

nr 5

20

Levels of ochratoxin A in IgG against conidia of Penicillium verrucosum in blood samples from healthy farm workers

58%

Skaug M. A.

Annals of Agricultural and Environmental Medicine

|

2003

|

tom 10

|

nr 1

Ochratoxin A (OTA) is a mycotoxin frequently found in human blood and milk samples in the colder climatic zones. In addition to dietary intake, exposure may occur by inhalation of toxin containing fungal conidia. The purpose of this work was to investigate the level of OTA in blood samples from farm workers and non-farm working controls, and to examine if serum levels of OTA were related to inhalatory exposure to conidia of Penicillium verrucosum, the main OTA producer in temperate climates. Blood samples from 210 participants were analysed for the presence of OTA and IgG antibodies against P. verrucosum conidia. The concentration of OTA was determined by HPLC (DL 10 ng/l), and the IgG level was determined by ELISA. All serum samples contained OTA (mean 397 ng/l, range 21-5534 ng/l). The OTA level in serum was unrelated to farm working, gender, age, and IgG level. The mean IgG level was significantly higher among farm workers than controls. Farm working, or increased inhalatory exposure to P. verrucosum, was not related to higher OTA serum levels. Inhalatory exposure to OTA from farm working seems to be of minor importance compared to dietary intake.

Ograniczanie wyników

Human ventilatory efficiency and respiratory sinus arrhythmia during head-up tilt

Inhaled insulin - does it become reality?

Systemic treatment by inhalation of macromolecules - principles, problems, and examples

Efficacy and safety of once or twice daily inhalation of extrafine HFA beclomethasone dipropionate in patients with mild to moderate asthma

Treatment of systemic diseases by inhalation of biomolecule aerosols

Inhalation of tobramycin in patients with cystic fibrosis: comparison of two methods

Tussigenic agents in the measurement of cough reflex sensitivity

Late consequences of respiratory system burns

The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy

The impact of hypertonic saline inhalation on mucociliary clearance and nasal nitric oxide

Organic dust induced pulmonary disease - the role of mould derived beta-glucan

Mesitylene [1,3,5-trimethylbenzene] in the liver, lung, kidney, and blood and 3,5-dimethylbenzoic acid in the liver, lung, kidney and urine od rats after single and repeated inhalation exposure to mesitylene

Adaptable changes in rat liver microsomal enzyme activities in response to inhalation with C6-C9 hydrocarbon petroleum fraction

Functional diagnosis of respiratory efficiency of cokery mill employees working in a polluted atmosphere

Influence of xanthine derivatives on cough and airway reactivity in guinea pigs

Anticoagulative effects of the inhaled low molecular weight heparin certoparin in healthy subjects

Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs

Hydrogen gas reduces brain injury in a global cerebral ischemia model

The influence of autonomic neuropathy on cough reflex sensitivity in children with diabetes mellitus type 1

Levels of ochratoxin A in IgG against conidia of Penicillium verrucosum in blood samples from healthy farm workers