Wyniki wyszukiwania

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Ghrelin attenuates the development of acute pancreatitis in rats

100%

Dembinski A., Warzecha Z., Ceranowicz P., Tomaszewska R., Stachura J., Konturek S. J., Konturek P. C.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 4

Ghrelin, a circulating growth hormone-releasing peptide isolated from human and rat stomach, stimulates growth hormone secretion, food intake and exhibits gastroprotective properties. Ghrelin is predominantly produced by a population of endocrine cells in the gastric mucosa, but its presence in bowel, pancreas, pituitary and hypothalamus has been reported. In human fetal pancreas, ghrelin is expressed in a prominent endocrine cell population. In adult pancreatic islets the population of these cell is reduced. The aim of present study was to investigate the influence of ghrelin administration on the development of acute pancreatitis. Methods: Acute pancreatitis was induced in rat by caerulein injection. Ghrelin was administrated twice (30 min prior to the first caerulein or saline injection and 3 h later) at the doses: 2, 10 or 20 nmol/kg. Immediately after cessation of caerulein or saline injections the following parameters were measured: pancreatic blood flow, plasma lipase activity, plasma interleukin-1ß (IL-1ß) and interleukin 10 (IL-10) concentration, pancreatic DNA synthesis, and morphological signs of pancreatitis. Results: Administration of ghrelin without induction of pancreatitis did not affect significantly any parameter tested. Caerulein led to the development of acute edematous pancreatitis. Treatment with ghrelin at the dose 2 nmol/kg, during induction of pancreatitis, was without effect on pancreatic histology or biochemical and functional parameters. Treatment with ghrelin at the dose 10 and 20 nmol/kg attenuated the development of pancreatitis and the effects of both doses were similar. Administration of ghrelin (10 or 20 nmol/kg) reduced inflammatory infiltration of pancreatic tissue and vacuolization of acinar cells. Also, plasma lipase activity and plasma IL-1ß concentration were reduced, and caerulein-induced fall in pancreatic DNA synthesis was reversed. Administration of ghrelin at the dose 10 and 20 nmol/kg was without effect on caerulein-induced pancreatic edema and pancreatitis-related fall in pancreatic blood flow. Conclusions: (1) Administration of ghrelin attenuates pancreatic damage in caerulein-induced pancreatitis; (2) Protective effect of ghrelin administration seems to be related the inhibition in inflammatory process and the reduction in liberation of pro-inflammatory IL-1ß.

2

Assessment of inflammatory infiltration and angiogenesis in the thrombus and the wall of abdominal aortic aneurysms on the basis of histological parameters and computed tomography angiography study

84%

Lukasiewicz A., Reszec J., Kowalewski R., Chyczewski L., Lebkowska U.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 4

3

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Attempts of modification of apoptosis in the course of experimental trichinellosis in mice

84%

Karmanska K., Piekarska J., Widyma A.

Wiadomości Parazytologiczne

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2001

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tom 47

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nr 2

The influence of the some immunomodulators (PHA-P, TFX and dexamethasone) on the process of apoptosis, occurring in the course of trichinellosis in mice, has been studied. It has been found that PHA-P activates this process in the jejunum mucosa and prolongs it in the muscular inflammatory infiltration, whereas TFX has no influence and dexamethasone distinctly decreases the level of the apoptotic cells. The number of the intestinal trichinae on the successive days of infection was similar in all groups of animals, however, the number of the muscular larvae in the groups receiving immunostimulators was much lower and in the group treated with dexamethasone - a little higher than that in control. As in mice receiving PHA-P and TFX, the cellular inflammatory infiltration in the muscles was larger than that in control, and in the group to which dexamethasone was administrated - smaller, the authors think that it was extensiveness of the infiltration and not the level of the apoptotic cells that influenced the number of the outliving larvae.

4

Procentowy udzial wybranych komorek nacieku zapalnego w miesniach myszy eksperymentalnie zakazonych Trichinella pseudospiralis

51%

Widyma A.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2002

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tom 01

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nr 2

45-51

5

Dynamika zmian wybranych komorek nacieku zapalnego w jelitach myszy eksperymentalnie zarazonych Trichinella pseudospiralis

51%

Wincewicz E., Widyma A.

Acta Scientiarum Polonorum. Medicina Veterinaria

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2006

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tom 05

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nr 2

19-26

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The effect of immunomodulating drugs on the percentage of apoptotic and necrotic lymphocytes in inflammatory infiltrations in the muscle tissue of mice infected with Trichinella spiralis

51%

Piekarska J., Szczypka M., Michalski A., Obminska-Mrukowicz B., Gorczykowski M.

Polish Journal of Veterinary Sciences

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2010

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tom 13

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nr 2

7

Reakcja pni drzew kasztanowca bialego na zastosowane infuzje 'Zelem do rownoczesnego zwalczania...'

43%

Baranowski T., Potocka E.

Progress in Plant Protection

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2007

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tom 47

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nr 1

179-183

Ograniczanie wyników

Ghrelin attenuates the development of acute pancreatitis in rats

Assessment of inflammatory infiltration and angiogenesis in the thrombus and the wall of abdominal aortic aneurysms on the basis of histological parameters and computed tomography angiography study

Attempts of modification of apoptosis in the course of experimental trichinellosis in mice

Procentowy udzial wybranych komorek nacieku zapalnego w miesniach myszy eksperymentalnie zakazonych Trichinella pseudospiralis

Dynamika zmian wybranych komorek nacieku zapalnego w jelitach myszy eksperymentalnie zarazonych Trichinella pseudospiralis

The effect of immunomodulating drugs on the percentage of apoptotic and necrotic lymphocytes in inflammatory infiltrations in the muscle tissue of mice infected with Trichinella spiralis

Reakcja pni drzew kasztanowca bialego na zastosowane infuzje 'Zelem do rownoczesnego zwalczania...'