Wyniki wyszukiwania

1

Role of the p38 MAPK pathway in induction of iNOS expression in human leukocytes

100%

Jablonska E., Ratajczak W., Jablonski J.

Folia Biologica

|

2008

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tom 56

|

nr 1-2

83-89

2

The effect of Naja naja oxiana snake venom against Leishmania tropica confirmed by advanced assays

84%

Sharifi I., Tabatabaie F., Nikpour S., Mostafavi M., Oliaee R. T., Sharifi F., Babaei Z., Jafari E., Salarkia E., Shahbazzadeh D.

Acta Parasitologica

|

2021

|

tom 66

|

nr 2

3

Blockade of nitric oxide formation in the rat brain does not disturb development of endotoxin tolerance

84%

Soszynski D., Daniluk M., Galazka M., Dmitruk K.

Journal of Physiology and Pharmacology

|

2013

|

tom 64

|

nr 6

4

ST36 electroacupuncture activates nNOS, iNOS and ATP-sensitive potassium channels to promote orofacial antinociception in rats

84%

Almeida R. T., Galdino G., Perez A. C., Silva G., Romero T. R., Duarte I. D.

Journal of Physiology and Pharmacology

|

2017

|

tom 68

|

nr 1

5

Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats

84%

Kato S., Ohkawa F., Ito Y., Amagase K., Takeuchi K.

Journal of Physiology and Pharmacology

|

2009

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tom 60

|

nr 4

147-155

The role of nitric oxide synthase (NOS) isozymes in the aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats was investigated. Two weeks after injection of Freund’s complete adjuvant, the animals were given indomethacin, and the stomach was examined for damage 4 h later. Indomethacin caused hemorrhagic lesions in the normal rat stomach, and these lesions were markedly aggravated in arthritic rats. Pretreatment with L-NAME (a nonselective inhibitor of NOS) and aminoguanidine (a relative selective inhibitor of iNOS) did not affect the ulcerogenic response in normal rats but dose-dependently prevented the aggravation of lesions in arthritic rats, but the effect of aminoguanidine was apparently less than that of L-NAME. The increased ulcerogenic response in arthritic rats was significantly suppressed by 1400 W (a selective inhibitor of iNOS) and L-NIO (a selective inhibitor of eNOS) but not by L-NPA (a selective inhibitor of nNOS). The concurrent administration of 1400 W and L-NIO almost totally abolished the aggravation of damage in arthritic rats. The expressions of eNOS and iNOS but not nNOS in the gastric mucosa were clearly enhanced in arthritic rats. Mucosal levels of non-protein sulfhydryls were significantly lower in arthritic rats than those in normal rats. The aggravation of damage in arthritic rats was significantly prevented by glutathione. These results suggest that the increased ulcerogenic response to indomethacin in arthritic rat stomachs is mediated by NO derived from eNOS in addition to iNOS. It is assumed that eNOS/NO may act harmfully on the gastric mucosa of arthritic rats with mucosal SH deficiency.

6

Neuroprotective effect of resveratrol against late cerebral ischemia reperfusion induced oxidative stress damage involves upregulation of osteopontin and inhibition of interleukin-1beta

84%

Al Dera H.

Journal of Physiology and Pharmacology

|

2017

|

tom 68

|

nr 1

7

Japanese quince (Chaenomeles japonica) leaf phenol extract as modulator of the inflammatory response in lipopolysaccharide-triggered murine macrophage RAW 264.7 cells

84%

Chojnacka K., Owczarek K., Caban M., Sosnowska D., Polka D., Koziolkiewicz M., Fichna J., Lewandowska U.

Journal of Physiology and Pharmacology

|

2020

|

tom 71

|

nr 6

8

Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats

84%

Hayashi S., Kurata N., Kitahirachi E., Nishimura Y., Amagase K., Yano T., Takeuchi K.

Journal of Physiology and Pharmacology

|

2013

|

tom 64

|

nr 4

9

Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase

84%

Konturek P. C., Kania J., Hahn E. G., Konturek J. W.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 5

125-136

Aspirin (ASA) represents an important risk factor for gastric mucosal injury. Recently, vitamin C releasing aspirin (ASA-VitC) has been shown to reduce gastric toxicity of ASA in animal model of gastric injury. The aim of the present study was to compare the effect of ASA and ASA-VitC on the gastric mucosal damage before and after Helicobacter pylori (Hp) eradication in 10 young healthy Hp-positive volunteers. All subjects underwent endoscopy at day 0 (before ASA or ASA-VitC treatment) and at day 3 following treatment (1.6 g ASA/day or 1.6 g ASA + 0.96 g Vit C/day). In addition, in vitro experiments were performed in which gastric mucosal cell line (MKN-45 cells) was incubated with ASA or ASA-VitC alone or in combination with H.pylori. Expression of constitutive and inducible NO synthase (cNOS, iNOS) was analyzed by Western blot. Moreover, COX-2 expression was analyzed in gastric biopsies at mRNA and protein level by RT-PCR and Western blot, repectively. In humans, treatment with ASA-VitC induced significantly less gastric mucosal lesions than plain ASA. Furthermore, in comparision to plain ASA, ASA-VitC caused stronger inhibition of cNOS and increase in iNOS expression in the gastric mucosa. in vitro studies demonstrated a significant increase in iNOS expression in MKN-45 cells incubated with Hp. This effect was aggravated by the addition of ASA, but not ASA-VitC, to MKN-45 cells incubated with H.pylori. Both ASA and ASA-VitC stimulated the COX-2 expression in the gastric mucosa. We conclude that ASA-VitC in comparison with ASA induces less gastric mucosal damage and this protective effect may be due to its inhibitory effect on iNOS expression.

10

Effects of IFN-beta1a and IFN-beta1b treatment on the expression of cytokines, inducible NOS (NOS type II), and myelin proteins in animal model of multiple sclerosis

84%

Lubina-Dabrowska N., Stepien A., Sulkowski G., Dabrowska-Bouta B., Langfort J., Chalimoniuk M.

Archivum Immunologiae et Therapiae Experimentalis

|

2017

|

tom 65

|

nr 4

11

Immunohistochemical visualization of pro-inflammatory cytokines and enzymes in ovarian tumors

84%

Plewka D., Kowalczyk A. E., Jakubiec-Bartnik B., Morek M., Bogunia E., Kmiec A., Wierzbicki P. M., Plewka A.

Folia Histochemica et Cytobiologica

|

2014

|

tom 52

|

nr 2

12

Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors does not influence febrile response in rats during turpentine abscess

84%

Soszynski D., Chelminiak M.

Journal of Physiology and Pharmacology

|

2007

|

tom 58

|

nr 4

The purpose of this study was to investigate the role of neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS) in the brain during development of fever in response to localized tissue inflammation caused by injection of turpentine in freely moving biotelemetered rats. To determine the role of both NOSs in turpentine-induced fever, we injected vinyl-L-NIO (N5 – (1-Imino-3-butenyl) – ornithine (vL-NIO), a selective nNOS inhibitor, and aminoguanidine hydrochloride, a selective iNOS inhibitor, intracerebroventricularly (i.c.v.) 5 h after turpentine injection. Rats responded with fever to intramuscular injection of 20 µl of turpentine that commenced about 5 - 6 h after injection and reached peak value between 9 - 11 h post-turpentine. The inhibition of nNOS as well as iNOS in the brain did not affect fever induced by turpentine. Fevers in control rats (treated i.c.v. with pyrogen-free water) and iNOS or nNOS inhibitor-i.c.v. treated rats injected with turpentine were essentially the same. Furthermore, on the basis of these data, we concluded that iNOS and nNOS inside the brain do not participate in generation of fever to turpentine in rats.

13

Lipopolysaccharide changes sialylation pattern in the mouse central nervous system

67%

Wielgat P., Holownia A., Braszko J. J.

Journal of Physiology and Pharmacology

|

2012

|

tom 63

|

nr 5

14

Inducible nitric oxide synthase in duodenum of children with Giardia lamblia infection

67%

Mokrzycka M., Kolasa A., Kosierkiewicz A., Wiszniewska B.

Folia Histochemica et Cytobiologica

|

2010

|

tom 48

|

nr 2

191-196

15

Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin, Oxytocin, ANP, eNOS and iNOS

67%

Mauro A., Buscemi M., Provenzano S., Gerbino A.

Folia Histochemica et Cytobiologica

|

2011

|

tom 49

|

nr 2

16

Chronic stress adaptation of the nitric oxide synthases and IL-1beta levels in brain structures and hypothalamic-pituitary-adrenal axis activity induced by homotypic stress

67%

Gadek-Michalska A., Tadeusz J., Rachwalska P., Bugajski J.

Journal of Physiology and Pharmacology

|

2015

|

tom 66

|

nr 3

17

Spent hops (Humulus lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated raw 264.7 macrophage

67%

Caban M., Chojnacka K., Owczarek K., Laskowska J., Fichna J., Podsedek A., Sosnowska D., Lewandowska U.

Journal of Physiology and Pharmacology

|

2020

|

tom 71

|

nr 1

18

Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions

67%

Shimada A., Kohara Y., Naota M., Kobayashi Y., Morita T., Inoue K., Takano H.

Folia Histochemica et Cytobiologica

|

2015

|

tom 53

|

nr 4

19

Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells

67%

Jang S. H., Lim J. W., Kim H.

Journal of Physiology and Pharmacology. Supplement

|

2009

|

tom 60

|

nr 7

20

Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers

67%

Konturek S. J., Konturek P. C., Brzozowski T.

Journal of Physiology and Pharmacology. Supplement

|

2006

|

tom 57

|

nr 5

51-66

The degree of gastric damage following to exposition of the mucosa to noxious agents depends upon a balance between the factors promoting this damage and those activating the natural defense mechanisms. Recent findings, presented in this review, provide evidence that melatonin prevents the formation of acute gastric lesions induced by stress and accelerates healing of chronic gastric ulcers due to increase in the activity of nitric oxide (NO) synthase (NOS)-NO and cyclooxygenase (COX)-prostaglandin E2 (PGE2) systems resulting in the increase of mucosal blood flow and mucosal integrity. Melatonin is produced and released into the circulation by the pineal gland and, in many times larger amounts, by the gastrointestinal tract. Due to its anti-inflammatory and anti-oxidant properties, melatonin may be one of the most efficient protective factors preventing the development of acute gastric damage and accelerating healing of chronic gastric ulcers probably due to reduction in proinflammatory cytokine production, scavenging of the radical oxygen species and activation of COX-PG and NOS-NO systems as well as stimulating the afferent sensory nerves in the brain-gut axis.

Ograniczanie wyników

Role of the p38 MAPK pathway in induction of iNOS expression in human leukocytes

The effect of Naja naja oxiana snake venom against Leishmania tropica confirmed by advanced assays

Blockade of nitric oxide formation in the rat brain does not disturb development of endotoxin tolerance

ST36 electroacupuncture activates nNOS, iNOS and ATP-sensitive potassium channels to promote orofacial antinociception in rats

Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats

Neuroprotective effect of resveratrol against late cerebral ischemia reperfusion induced oxidative stress damage involves upregulation of osteopontin and inhibition of interleukin-1beta

Japanese quince (Chaenomeles japonica) leaf phenol extract as modulator of the inflammatory response in lipopolysaccharide-triggered murine macrophage RAW 264.7 cells

Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats

Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase

Effects of IFN-beta1a and IFN-beta1b treatment on the expression of cytokines, inducible NOS (NOS type II), and myelin proteins in animal model of multiple sclerosis

Immunohistochemical visualization of pro-inflammatory cytokines and enzymes in ovarian tumors

Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors does not influence febrile response in rats during turpentine abscess

Lipopolysaccharide changes sialylation pattern in the mouse central nervous system

Inducible nitric oxide synthase in duodenum of children with Giardia lamblia infection

Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin, Oxytocin, ANP, eNOS and iNOS

Chronic stress adaptation of the nitric oxide synthases and IL-1beta levels in brain structures and hypothalamic-pituitary-adrenal axis activity induced by homotypic stress

Spent hops (Humulus lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated raw 264.7 macrophage

Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions

Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells

Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers