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In-silico prediction and observations of nuclear matrix attachment

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Platts A. E., Quayle A. K., Krawetz S. A.

Cellular and Molecular Biology Letters

2006

tom 11

nr 2

The nuclear matrix is a functionally adaptive structural framework interior to the nuclear envelope. The nature and function of this nuclear organizer remains the subject of widespread discussion in the epigenetic literature. To draw this discussion together with a view to suggest a way forward we summarize the biochemical evidence for the modalities of DNA-matrix binding alongside the in-silico predictions. Concordance is exhibited at various, but not all levels. On the one hand, both the reiteration and sequence similarity of some elements of Matrix Attachment Regions suggest conservation. On the other hand, in-silico predictions suggest additional unique components. In bringing together biological and sequence evidence we conclude that binding may be hierarchical in nature, reflective of a biological role in replicating, transcribing and potentiating chromatin. Nuclear matrix binding may well be more complex than the widely accepted simple loop model.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Krawetz S. A.

1 Platts A. E.

1 Quayle A. K.

1 2006

Wyniki wyszukiwania

In-silico prediction and observations of nuclear matrix attachment