Wyniki wyszukiwania

1

Nitrogranulogen: a strong inhibitor of human lymphocyte proliferation

100%

Wasik M., Gorski A.

Archivum Immunologiae et Therapiae Experimentalis

|

1989

|

tom 37

|

nr 1-2

2

Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A

100%

Wieczorek Z., Pedyczak A., Bodalski T., Lisowski M., Trojnar J., Zimecki M., Siemion I. Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1992

|

tom 40

|

nr 3-4

3

Immunosuppressive activity of C-terminal fragments of tachykinins

100%

Siemion I. Z., Kubik A., Zimecki M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1994

|

tom 42

|

nr 3

4

Syntheses and properties of selected derivatives of pyrimido[5,4-e]-l,3-thiazine and pyrimido[4,5-d]pyrimidine

86%

Malinka W., Zawisza T., Zajac H. E.

Archivum Immunologiae et Therapiae Experimentalis

|

1989

|

tom 37

|

nr 3-4

5

Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A

86%

Siemion I. Z., Cebrat M., Lisowski M., Zimecki M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1992

|

tom 40

|

nr 5-6

6

Immunosuppressive activity of analogs of tripeptide Lys-Arg-Pro with D-amino acid residues

86%

Siemion I. Z., Kluczyk A., Slon J. J., Zimecki M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1994

|

tom 42

|

nr 3

7

The immunosuppressive activities of newly synthesized azaphenothiazines in human and mouse models

72%

Zimecki M., Artym J., Kocieba M., Pluta K., Morak-Mlodawska B., Jelen M.

Cellular and Molecular Biology Letters

|

2009

|

tom 14

|

nr 4

622-635

In this study, we evaluated the activities of new types of azaphenothiazines in the following immunological assays: the proliferative response of human peripheral blood mononuclear cells induced by phytohemagglutin A or anti-CD3 antibodies; lipopolysaccharide-induced cytokine production by human PBMC; the secondary, humoral immune response in mice to sheep erythrocytes (in vitro); and delayed-type hypersensitivity in mice to ovalbumin (in vivo). In some tests, chlorpromazine served as a reference drug. The compounds exhibited differential inhibitory activities in the proliferation tests, with 10H-2,7-diazaphenothiazine (compound 1) and 6-(3-dimethylaminopropyl)diquinothiazine (compound 8) being most suppressive. Compound 1 was selected for further studies, and was found to be strongly suppressive in the humoral immune response even at low concentrations (1 μg/ml). Compound 1 also inhibited the delayed-type hypersensitivity lipopolysaccharide-induced production of tumor necrosis factor and interleukin-6 in cultures of human blood cells. As there were only two subjects in this study, the effects of these compounds on human blood cells need to be confirmed. In this paper, we also discuss the structure-activity relationships of selected compounds.

8

Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A

72%

Siemion I. Z., Cebrat M., Pedyczak A., Zimecki M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1993

|

tom 41

|

nr 5-6

9

Influence of lys-residue deletion on the immunomodulatory activity of peptides related to immunosuppressive region of lactoferrin

58%

Slon J. I., Siemion I. Z., Zimecki M., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1995

|

tom 43

|

nr 3-4

10

Immunosuppressive activity of some peptides related to cycloamanide A [CyA A] and to the active fragment of a peptide immunomodulator from ovine colostrum

58%

Bolewska-Pedyczak E., Wieczorek Z., Zimecki M., Siemion I. Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1993

|

tom 41

|

nr 5-6

11

Immunomodulatory activity of G-actin fragments containing a thymopentin-like sequence

58%

Siemion I. Z., Strug I., Wyslouch-Cieszynska A., Nowak E., Wieczorek Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1997

|

tom 45

|

nr 5-6

12

Immunosuppressive activity of alanine analogs of cyclolinopeptide A

58%

Wieczorek Z., Zimecki M., Pedyczak A., Lisowski M., Siemion I. Z.

Archivum Immunologiae et Therapiae Experimentalis

|

1993

|

tom 41

|

nr 5-6

Ograniczanie wyników

Nitrogranulogen: a strong inhibitor of human lymphocyte proliferation

Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A

Immunosuppressive activity of C-terminal fragments of tachykinins

Syntheses and properties of selected derivatives of pyrimido[5,4-e]-l,3-thiazine and pyrimido[4,5-d]pyrimidine

Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A

Immunosuppressive activity of analogs of tripeptide Lys-Arg-Pro with D-amino acid residues

The immunosuppressive activities of newly synthesized azaphenothiazines in human and mouse models

Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A

Influence of lys-residue deletion on the immunomodulatory activity of peptides related to immunosuppressive region of lactoferrin

Immunosuppressive activity of some peptides related to cycloamanide A [CyA A] and to the active fragment of a peptide immunomodulator from ovine colostrum

Immunomodulatory activity of G-actin fragments containing a thymopentin-like sequence

Immunosuppressive activity of alanine analogs of cyclolinopeptide A