Wyniki wyszukiwania

1

Differential role of polyamines in hyperplasia and hypertrophy

100%

Manteuffel-Cymborowska M.

Acta Biochimica Polonica

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1993

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tom 40

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nr 3

2

Airborne and substrate-borne communications of Microtus [Terricola] gerbei and M. [T.] duodecimcostatus

75%

Giannoni S. M., Marquez R., Borghi C. E.

Acta Theriologica

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1997

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tom 42

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nr 2

The repertoire of airborne and substrate-borne communications is described for two species of mote-voles: Microtus (Terrícola) gerbei {de Séiys-Longchamps, 1847) and M. (T.) duodecimcostatus (de Sélys-Longchamps, 1839). The behavioural significance of the different types of sounds emitted was analysed from observations of intraspecific interactions in captive environments. Substrate-borne signals were used more often by dominant individuals, and were predominantly recorded in the more aggressive species, M. duodecimcostatus. The use of substrate-borne signals is much more prevalent in the more aggressive M. duodecimcostatus, while the less aggressive M. gerbei has a larger acoustical repertoire.

3

Abnormal incisor growth in Eurasian beaver

75%

Rosell F., Kile N. B.

Acta Theriologica

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1998

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tom 43

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nr 3

An abnormally long incisor of an adult Eurasian beaver Castor fiber Linnaeus, 1758 is reported. The animal weighed about 20 kg and was in good condition when shot at 3 years of age. The tooth had grown at an angle in towards the beaver's left eye. Assuming the animal to be 35 months old and total tooth length to be 13.5 cm, then growth rate would have been 0.39 cm per month. This report indicates that beaver can survive despite abnormal growth of one incisor.

4

Reactivity of astrocytes in hippocampal CA1 area in rats after administration of habanero peppers

63%

Jaworska-Adamu J., Krawczyk A., Rycerz K., Golynski M.

Folia Histochemica et Cytobiologica

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2021

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tom 59

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nr 1

5

Simple obesity and renal function

63%

Sikorska D., Grzymislawska M., Roszak M., Gulbicka P., Korybalska K., Witkowski J.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 2

6

Changes in the lymphatic vessels network of the larynx caused by atrophy and hypertrophy of mucosa

63%

Skarzynski H., Skarzynska B., Kukwa A., Nowak M.

Folia Morphologica

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1988

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tom 47

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nr 1-4

7

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Discoloured seeds of amaranth plant infected by Alternaria alternata: physiological, histopathological alterations and fungal secondary metabolites associated or registered

63%

Noelting M. C., Sisterna M., Lovisolo M., Molla-Kralj A., Lori G., Sandoval M. C., Sulyok M., Molina M. C.

Journal of Plant Protection Research

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2016

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tom 56

|

nr 3

In the present study the aspects of discolouration that could influence both the production and consumption of amaranth were analyzed with the objectives to identify the presence of Alternaria alternata on seeds, to analyze possible changes in the anatomy of seed tissues and to detect the presence of fungal secondary metabolites. Component plating, histopathological and mycological analyses on discoloured seeds allowed i) location of propagules of A. alternata in all seminal components; ii) observation of hypertrophies in perisperm and embryo and iii) determination of several fungal secondary metabolites, mainly high concentrations of tenuazonic acid. To our knowledge, the information presented in this paper, related to physiological, histopathological changes and fungal secondary metabolites on discoloured seeds of (Amaranthus mantegazzianus syn. A. caudatus subsp. mantegazzianus (Pass) Hanelt affected by A. alternata, is the first worldwide record.

8

Changes of summer phytoplankton communities in Lake Swarzedzkie in the 2000-2003 period

63%

Stefaniak K., Goldyn R., Kowalczewska-Madura K.

Oceanological and Hydrobiological Studies

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2007

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tom 36

|

nr Suppl.1

9

Properties of ventricular myocytes isolated from the hypertrophied and failing hearts of spontaneously hypertensive rats

63%

Emanuel K., Mackiewicz U., Pytkowski B., Lewartowski B.

Journal of Physiology and Pharmacology

|

1999

|

tom 50

|

nr 2

10

Morphological analysis of the myocardial fiber architecture of ventriculus cordis in normal and malformed human hearts

63%

Calguner E., Gozil R., Erdogan D., Kadioglu D.

Folia Morphologica

|

1995

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tom 54

|

nr 1

11

Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo-hippocampal pathways

63%

Skup M., Bacia A., Koczyk D., Jeglinski W., Zaremba M., Oderfeld-Nowak B.

Acta Neurobiologiae Experimentalis

|

1996

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tom 56

|

nr 2

12

Tomato expansin isoform LeExp5 promotes cell hypertrophy during syncytium development in tomato roots infected with potato cyst nematode

63%

Fudali S., Sobczak M., Janakowski S., Golinowski W.

Biological Letters

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2005

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tom 42

|

nr 2 Spec.Vol.

13

Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes

63%

Kovacic-Milivojevic B., Damsky C. C., Gardner D. G., Ilic D.

Cellular and Molecular Biology Letters

|

2002

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tom 07

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nr 2

The vertebrate heart responds to hemodynamic load with the enlargement of postmitotic, terminally differentiated cardiac myocytes. Such hypertrophic changes are characterized by alterations in sarcomeric organization and gene expression. Previously, we established a role for a nonreceptor tyrosine kinase, focal adhesion kinase, in signaling the changes in cytoskeletal organization associated with hypertrophy [1], Here, we report on data supporting a key role for p130Cas in this process. In neonatal cardiac myocytes FAK, Cas and paxillin are located in sarcomeric Z-lines, suggesting that the Z-line is an important signaling locus in these cells. The expression of different Cas mutants results in a nearly complete loss of sarcomeric organization in these myocytes. Moreover, expression of the C-terminal focal adhesion-targeting domain of FAK both disrupted sarcomeric organization and interfered with the localization of endogenous Cas to Z-lines. These findings suggest that the association of FAK and Cas and the preservation of multiple protein-interaction motifs of Cas are required for the correct assembly of sarcomeres in cardiac myocytes.

14

Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart

63%

Karbowska J., Kochan Z., Smolenski R. T.

Cellular and Molecular Biology Letters

|

2003

|

tom 08

|

nr 1

Cardiac hypertrophy in humans is associated with a decrease in myocardial fatty acid β-oxidation (FAO) and accompanying alterations in metabolic gene expression. Flux through the cardiac FAO pathway, which is the principal source of energy production in the adult mammalian heart, is tightly controlled in accordance with energy demands. In rodents, the FAO pathway is under control of a nuclear peroxisome proliferator-activated receptor α (PPARα). We sought to delineate the molecular regulatory events involved in the energy substrate preference switch from fatty acids to glucose during cardiac hypertrophic growth in humans. We analysed the amount of PPARα protein in human cardiac tissue. PPARα protein level was measured in homogenates prepared from left ventricular biopsies taken from five control donor hearts and compared to the amount of this transcription factor in biopsies from five patients with compensated end-stage heart failure (HF) at the time of transplantation. Using Western blot analysis with a monoclonal antibody against human PPARα, we observed a significant decrease (54%) in the mean amount of PPARα in the group of HF patients compared to that in the donor tissue. This study indicates that the decrease in cardiac PPARα transcription factor gene expression observed in the failing human heart could play an important role in a reduction in fatty acid utilisation by the adult heart during cardiac hypertrophy.

15

The role of IL-1 in the pathogenesis of heart disease

51%

Bujak M., Frangogiannis N. G.

Archivum Immunologiae et Therapiae Experimentalis

|

2009

|

tom 57

|

nr 3

165-176

16

Isoproterenol induces in vivo functional and metabolic abnormalities; similar to those found in the infarcted rat heart

51%

Heather L. C., Catchpole A. F., Stuckey D. J., Cole M. A., Carr C. A., Clarke K.

Journal of Physiology and Pharmacology

|

2009

|

tom 60

|

nr 3

31-39

Chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. Yet, despite widespread use of this model, the effects of isoproterenol on in vivo cardiac function and substrate metabolism are unknown. Isoproterenol (5 mg.kg-1.day-1) was infused for 7 days in male Wistar rats (n = 22). In vivo magnetic resonance imaging (MRI) showed that left ventricular mass increased by 37% and end-diastolic and systolic volumes increased by 33% and 73%, respectively, following isoproterenol infusion. Cardiac function at the base of the left ventricle was normal, but apical ejection fraction decreased from 90% to 31% and apical free wall thickening decreased by 94%, accompanied by increased fibrosis and inflammation. Myocardial palmitate oxidation rates were 25% lower, and citrate synthase and medium chain acyl-coenzyme A dehydrogenase activities were reduced by 25% and 29%, respectively, following isoproterenol infusion. Fatty acid transporter protein levels were 11-52% lower and triglyceride concentrations were 55% lower in isoproterenol-infused rat hearts. Basal glycolysis and glycogen concentration were not changed, yet insulin stimulated glycolysis was decreased by 32%, accompanied by 33% lower insulin stimulated glucose transporter, GLUT4, protein levels in rat hearts following isoproterenol infusion, compared with controls. In conclusion, isoproterenol infusion impaired in vivo cardiac function, induced hypertrophy, and decreased both fatty acid and glucose metabolism, changes similar in direction and magnitude to those found in the rat heart following moderate severity myocardial infarction.

17

Cardiovascular effects of the combination of levosimendan and valsartan in hypertensive Dahl/Rapp rats

51%

Biala A., Finckenberg P., Korpi A., Loytainen M., Martonen E., Levijoki J., Mervaala E.

Journal of Physiology and Pharmacology

|

2011

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tom 62

|

nr 3

Hypertension is the main risk factor for left ventricular hypertrophy and development of diastolic heart failure. There is no yet treatment, which can effectively reduce mortality in patients suffering from heart failure with preserved systolic function. We tested whether the calcium sensitizer levosimendan and the AT1-receptor antagonist valsartan could protect from salt-induced hypertension, cardiovascular mortality and heart failure in Dahl/Rapp salt-sensitive rats fed for 7 weeks with a high salt diet (8% NaCl). Levosimendan (1 mg/kg/day via drinking water) and valsartan (30 mg/kg in the food) monotherapies and their combination prevented mortality in Dahl/Rapp rats. The drug combination evoked an additive effect on blood pressure, cardiac hypertrophy, cardiomyocyte cross-sectional area, target organ damage and myocardial ANP mRNA expression. There was a close correlation between systolic blood pressure and cardiac hypertrophy, cardiac and renal damage. As compared to Dahl/Rapp controls kept on low-salt diet (NaCl 0.3%). The high salt rats exhibited impaired diastolic relaxation as assessed by isovolumic relaxation time. Levosimendan alone and in combination with valsartan, improved diastolic relaxation without significantly improving systolic function. Our findings are evidence for an additive effect between levosimendan and valsartan on blood pressure and a blood pressure- dependent protection against the development of salt-induced target organ damage. The present study also demonstrates that levosimendan, alone or in combination with valsartan, can correct diastolic dysfunction induced by salt-dependent hypertension.

18

Pathological changes in the microstructure of longissimus lumborum muscle from five breeds of pigs

51%

Wojtysiak D.

Folia Biologica

|

2012

|

tom 60

|

nr 1-2

19

Relationship between airway wall thickness assessed by high-resolution computed tomography and lung function in patients with asthma and chronic obstructive pulmonary disease

51%

Kosciuch J., Krenke R., Gorska K., Zukowska M., Maskey-Warzechowska M., Chazan R.

Journal of Physiology and Pharmacology. Supplement

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2009

|

tom 60

|

nr 5

20

Myogenesis – possibilities of its stimulation in chickens

51%

Sobolewska A., Elminowska-Wenda G., Bogucka J., Szpinda M., Walasik K., Bednarczyk M., Paruszewska-Achtel M.

Folia Biologica

|

2011

|

tom 59

|

nr 3-4

Ograniczanie wyników

Differential role of polyamines in hyperplasia and hypertrophy

Airborne and substrate-borne communications of Microtus [Terricola] gerbei and M. [T.] duodecimcostatus

Abnormal incisor growth in Eurasian beaver

Reactivity of astrocytes in hippocampal CA1 area in rats after administration of habanero peppers

Simple obesity and renal function

Changes in the lymphatic vessels network of the larynx caused by atrophy and hypertrophy of mucosa

Discoloured seeds of amaranth plant infected by Alternaria alternata: physiological, histopathological alterations and fungal secondary metabolites associated or registered

Changes of summer phytoplankton communities in Lake Swarzedzkie in the 2000-2003 period

Properties of ventricular myocytes isolated from the hypertrophied and failing hearts of spontaneously hypertensive rats

Morphological analysis of the myocardial fiber architecture of ventriculus cordis in normal and malformed human hearts

Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo-hippocampal pathways

Tomato expansin isoform LeExp5 promotes cell hypertrophy during syncytium development in tomato roots infected with potato cyst nematode

Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes

Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart

The role of IL-1 in the pathogenesis of heart disease

Isoproterenol induces in vivo functional and metabolic abnormalities; similar to those found in the infarcted rat heart

Cardiovascular effects of the combination of levosimendan and valsartan in hypertensive Dahl/Rapp rats

Pathological changes in the microstructure of longissimus lumborum muscle from five breeds of pigs