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  1. 3 Acta Biochimica Polonica

  2. 3 Folia Histochemica et Cytobiologica

  3. 2 Archivum Immunologiae et Therapiae Experimentalis

  4. 2 Cellular and Molecular Biology Letters

  5. 1 Acta Physiologica Polonica

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  1. 2 Koter M.

  2. 2 Rogozinska M.

  3. 1 Amaning E. P.

  4. 1 Blasiak J.

  5. 1 Bonior J.

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  1. 1 2015

  2. 2 2011

  3. 1 2007

  4. 1 2005

  5. 3 2003

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1
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Content available

Life-threatening conditions in psychiatry - neuroleptic malignant syndrome (NMS)

100%
Kucmin T., Kucmin A., Plowas-Goral M., Jojczuk M.
Journal of Pre-Clinical and Clinical Research
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2015
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tom 09
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nr 1
The introduction of neuroleptics in the 1950’s was a turning point in psychiatric treatment. The new drugs brought hope to millions of patients and their doctors. However, there were also some side-effects, one of which is Neuroleptic malignant syndrome (NMS), a rare complication of antipsychotic treatment and untreated it may lead to mortality as high as 20%. The incidence of NMS, estimated to be 0.01–0.02%, has decreased significantly probably due to higher awareness of the diseases and shift to atypical antipsychotics. The aim of this study was to present the signs and symptoms of this rare condition and describe management possibilities since this condition is observed not only in psychiatric departments but also in emergency rooms. NMS is thought to be related to change caused by neuroleptics within the central nervous system due to dopamine D2 receptor antagonism, especially nigrostriatal pathways and the hypothalamus. There are three symptoms which are considered as major and indicate a high probability of NMS: muscle rigidity, hyperthermia (core body temperature above 38.5 °C), and elevated creatine phosphokinase concentration (above 1000 U/l). NMS is a diagnosis of exclusion and clinicians must be vigilant in detecting early signs of NMS. The basic management in NMS is antipsychotic discontinuation and proper supportive care of the patient (vital signs monitoring, hydration, correction of electrolyte and acid-base disturbances). In more severe cases, the introduction of bromocriptine or dantrolene, as well as benzodiazepines, may indicated. Further usage of neuroleptic in patients with a history of NMS should be with care, and low doses of low-potency neuroleptics or atypical neuroleptics seem to be the best treatment choice.
2

Changes in the ultrastructure and functions of immunocompetent cells under the influence of external heating, interleukin 1beta and leukocytic pyrogen

100%
Murzenok P. P., Netukova N. I.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
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tom 42
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nr 4
3

Hyperthermia induced modification of erythrocyte membrane susceptibility to interaction with unsaturated fatty acids

100%
Rybczynska M.
Applied Biology Communications. Lublin Scientific Center
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1993
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tom 03
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nr 3-4
4

Insecticides and thermoregulation in insects

100%
Tegowska E.
Pestycydy
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2003
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nr 1-4
5

Effect of hyperthermia on morphology and histochemistry of spinal cord in the rat

84%
Godlewski A., Wygladalska-Jernas H., Szczech J.
Folia Histochemica et Cytobiologica
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1986
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tom 24
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nr 1
6

Activity of oxidative enzymes in neurolgia in vitro after hyperthermia

84%
Renkawek K., Majkowska J.
Folia Histochemica et Cytobiologica
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1984
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tom 22
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nr 3-4
7
Content available remote

Effects of hypovolemia on hypercapnic ventilatory response in experimental hyperthermia

84%
Zila I., Brozmanova A., Javorka M., Calkovska A., Javorka K.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
8

Neuropeptides and body temperature control during normothermia and fever

84%
Jansky L., Vybiral S.
Acta Physiologica Polonica
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1990
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tom 41
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nr 1-3
9

Hyperthermia can differentially modulate the repair of doxorubicin-damaged DNA in normal and cancer cells

84%
Blasiak J., Widera K., Pertynski T.
Acta Biochimica Polonica
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2003
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tom 50
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nr 1
Hyperthermia can modulate the action of many anticancer drugs, and DNA repair processes are temperature-dependent, but the character of this dependence in cancer and normal cells is largely unknown. This subject seems to be worth studying, because hyperthermia can assist cancer therapy. A 1-h incubation at 37°C of normal human pe­ripheral blood lymphocytes and human myelogenous leukemia cell line K562 with 0.5 juM doxorubicin gave significant level of DNA damage as assessed by the alkaline comet assay. The cells were then incubated in doxorubicin-free repair medium at 37°C or 41°C. The lymphocytes incubated at 37°C needed about 60 min to remove com­pletely the damage to their DNA, whereas at 41°C the time required for complete re­pair was shortened to 30 min. There was also a difference between the repair kinetics at 37°C and 41°C in cancer cells. Moreover, the kinetics were different in doxorubicin-sensitive and resistant cells. Therefore, hyperthermia may significantly affect the kinetics of DNA repair in drug-treated cells, but the magnitude of the effect may be different in normal and cancer cells. These features may be exploited in cancer chemotherapy to increase the effectiveness of the treatment and reduce unwanted ef­fects of anticancer drugs in normal cells and fight DNA repair-based drug resistance of cancer cells.
10
Content available remote

Increase of heat shock protein gene expression by melatonin in AR42J cells

84%
Bonior J., Jaworek J., Konturek S. J., Pawlik W. W.
Journal of Physiology and Pharmacology
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2005
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tom 56
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nr 3
Heat shock proteins (HSPs) have been reported to protect the pancreatic cells from the acute damage produced by caerulein overstimulation. However the effects of caerulein, melatonin or hyperthermia preconditioning on mRNA signal for HSP60 in the pancreatic acinar cells has not been examined yet. The aims of this study were: 1. To investigate the gene expression for HSP60 in the pancreatic AR42J cells stimulated by melatonin, caerulein or combination of both these substances. 2. To compare above changes with mRNA signal for HSP60 in pancreatic AR42J cells subjected to hyperthermia preconditioning. AR42J cells were incubated in standard medium at 37°C for: 0, 1, 3, 5, 12 or 24 h, under basal conditions. Above cells were then subjected to heat shock (42°C) for 0, 1 or 3 h. In the next part of the study AR42J cells were incubated in presence of caerulein (10-11, 10-9 or 10-7M), melatonin (10-8 or 10-6M), or combination of above under basal conditions or following heat shock pretreatment. Gene expression for HSP60 was determined by RT-PCR. The mRNA signal for HSP60 has been observed in AR42J cells under basal conditions, and this signal was markedly and time-dependently increased in these cells subjected to hyperthermia preconditioning. Incubation of AR42J cells in presence of melatonin (10-8 or 10-6M) resulted in the significant and dose-dependent increase of gene expression for HSP60 in both groups of AR42J cells: preconditioned and in those, which were not subjected to hyperthermia. Caerulein stimulation reduced mRNA signal for HSP60. The strongest signal has been observed after the exposition of AR42J cells to hyperthermia preconditioning, combined with melatonin and caerulein. We conclude that: 1. Gene expression for HSP60 has been detected in pancreatic AR42J cells under basal conditions. 2. Hyperthermia preconditioning resulted in a significant and time-dependent increase of HSP60 signal in pancreatic AR42J cells. 3. HSP60 gene expression was significantly increased in pancreatic AR42J cells stimulated by melatonin whereas caerulein reduced this signal. 4. The strongest gene expression for HSP60 has been found in the cells subjected to the combination of hyperthermia preconditioning, caerulein and melatonin.
11

Analysis of the relationship between hemoglobin-oxygen affinity and lipid peroxidation during fever

84%
Borisiuk M. V., Zinchuk V. V.
Acta Biochimica Polonica
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1995
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tom 42
|
nr 1
Endogenous hyperthermia was induced in rabbits by i.v. pyrogenal administration. Hemoglobin-oxygen affinity and parameters of free radical lipid oxidation in plasma and red blood cells were measured. The content of diene conjugates, malonic dialdehyde and Schiff bases were determined at a pyrogenal dose of 4 minimal pyrogenic doses/kg, and iron-initiated chemiluminescence, catalase activity and a-tocopherol concentration were determined at 6 minimal pyrogenic doses/kg. A rightward shift of the real oxyhemoglobin dissociation curve and activation of lipid peroxidation were observed. Relationships between the parameters measured were analyzed. Decreased hemoglobin-oxygen affinity is considered to be a possible mechanism of activation of free radicals during fever.
12

Kinetics of distribution of recirculating lymphocytes during whole body hyperthermia

84%
Amaning E. P., Olszewski W. L.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
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tom 42
|
nr 2
13

Thermotolerance in erythrocytes - damage to proteins

84%
Rogozinska M., Koter M.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
14
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Content available

The application of in vitro cattle embryo production system to study the influence of elevated temperature on oocyte maturation, fertilization and early embryonic development

67%
Rynkowska A., Rapala L., Trzeciak P., Duszewska A. M.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2011
|
tom 92
|
nr 1
15

Effect of in ovo injection of acetylsalicylic acid on morphotic parameters and heart work in chicken embryos exposed to hyperthermia

67%
Pawlak K., Lis M., Sechman A., Tombarkiewicz B., Niedziolka J.
Bulletin of the Veterinary Institute in Puławy
|
2011
|
tom 55
|
nr 1
The objective of the experiment was to define if in ovo injection of acetylsalicylic acid (ASA) during the final stage of embryogenesis has an effect on morphotic parameters and heart work of chicken embryos subjected to hyperthermia. Eggs (n=420) from a broiler breeder flock were incubated under standard conditions. On the 18th d of incubation, they were injected with 5 mg of ASA/50 µl of 0.9% NaCI and subsequently incubated during the hatching period under control (T=37.2°C) and hyperthermic (T=38.5°C) conditions. The cardiac function in the embryos was measured every day at the same time using contactless ballistocardiography. After hatching, the hearts were collected from randomly selected embryos or one-day old chicks to determine heart weight, relative heart weight, and ventricle wall thickness. It was shown that hyperthermia during the final stage of embryogenesis accelerated heart rate, inhibited its development, and reduced chicken hatchability. The injection of ASA on the 18th d of incubation in the group of embryos exposed to hyperthermia caused the heart rate to decrease to near optimum values. The administration of ASA also limited a decrease in heart weight and ventricle wall thickness, and improved chicken hatchability.
16

The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells

67%
Jakubowicz-Gil J., Paduch R., Gawron A., Kandefer-Szerszen M.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 1
17

Induction and decay of thermotolerance in human erythrocytes determined by hemolysis

67%
Rogozinska M., Koter M.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 1
Hemolysis was used as an endpoint for the measurement of damage to the plasma membrane in human erythrocytes after a single or a double heat shock. The thermotolerance of erythrocytes is a transitional phenomenon, reaching its maximum at a 3-hour incubation at 37°C between the heat shocks.
18

Construction of cDNA library from liver RNA of heat shocked rats and DNA sequence analysis of the clone containing the 3'-end untranslated region [3'UTR] of the heat inducible gene hsp70.2

67%
Lisowska K., Scieglinska D., Krawczyk Z.
Acta Biochimica Polonica
|
1996
|
tom 43
|
nr 2
cDNA library constructed from liver RNA of rats subjected to hyperthermia was used to isolate divergent 3' end untranslated regions (3'UTR) of heat inducible hsp70.1 and hsp70.2 genes. As a result of a double selection procedure with the use of DNA-DNA hybridization and PCR analysis 9 clones containing cDNA sequences derived from the 3'UTR of the hsp70.1 gene and 16 clones containing cDN A sequences derived from the 3'UTR of the hsp70.2 gene were selected. Nucleotide sequence of the cloned inserts was established and the Northern blot analysis was performed to identify the heat inducible transcript encoded by the hsp70.2 gene.
19
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Is the recently discovered EDA gene associated with anhidrotic ectodermal dysplasia?

67%
Kobielak K., Kobielak A., Trzeciak W. H.
Journal of Applied Genetics
|
1997
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tom 38
|
nr 3
The evidence from literature strongly suggests that Christ-Siemens-Touraine (CST) syndrome is associated with mutations of the newly discovered EDA gene. The gene is situated on the long arm of the X chromosome (Xq12.2-q13.1) and contains two exons separated by a 200 kbp intron. The 5’-untranslated region and most of the coding sequence are localized in exon 1, while three C-terminal amino acids are encoded by exon 2. The coding sequence was interrupted by translocations in three affected females: t(X;l), t(X;12), t(X;9), and submicroscopic deletions of the EDA gene were found in five males with CST syndrome, and point mutations were discovered in exon 1 in nine other patients. Northern blot analysis and in situ hybridization studies revealed that the EDA gene was expressed in the foetus, and postnatally in a specific type of skin cell and that the expression was limited to cells of ectodermal origin. A predicted protein product of the EDA gene contains 135 to 140 amino acids, organized in three distinct domains and may belong to class II transmembrane receptors.
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