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Seborrheic dermatitis (SD) is an inflammatory skin disorder affecting the scalp, face, and trunk, however, there are controversies surrounding its treatment. The aim of the study is to compare the efficacy of sertaconazole 2% cream with hydrocortisone 1% cream in the treatment of seborrheic dermatitis. In total, 138 patients suffering from seborrheic dermatitis were studied. Sixty-nine patients received local sertoconazole 2% cream and they were recommended to use the cream twice a day and for 4 weeks. To create a control group, 69 patients received hydrocortisone 1% cream twice a day for four weeks. At the time of referral, and at 2 and 4 weeks after their first visit, the patients were examined by a dermatologist to check the improvement of clinical symptoms. The mean age of patients was 36.45±13.23. The highest level of satisfaction (85.1%) was observed 28 days after sertaconazole consumption: 76.9% was recorded for the hydrocortisone group. No relapse of the disease one month after stopping treatment was observed in either the sertaconazole 2% group or the hydrocortisone 1% group. Sertaconazole 2% cream may be an excellent alternative therapeutic modality for treating seborrheic dermatitis.
This paper presents the study concerning the influence of hydrocortisone and progesterone on the growth and the content of protein and sugar in the green alga Chlorella vulgaris Beijerinck (Chlorophyceae). Progesterone, at the concentration of 10-4 M, showed a lethal effect on C. vulgaris and hydrocortisone - at the concentration of 10-3 M. Hydrocortisone, in range of concentrations 5×10-5-10-4 M, showed the greatest stimulating activity in C. vulgaris on the content of sugar, in comparison to progesterone, which has a most stimulating effect in the range of concentrations 5×10-5-5×10-6 M. It was found that in C. vulgaris progesterone is more active than hydrocortisone on the content of cellular sugar. However, progesterone acted inhibitory on the content of protein. The lowest inhibition of sugar and protein was observed under influence of hydrocortisone at the concentration of 5×10-6 M. The biological activity of hydrocortisone in the C. vulgaris studied was greater than that of progesterone with regard to the protein content.
Zbadano poziom miedzi w zębach szczurów w osteoporozie polekowej wywołanej stosowaniem hydrokortyzonu przez 4 i 8 tyg. Zawartość miedzi oznaczono także w zębach zwierząt, którym wraz Z hydrokortyzonem podawano Calcium gluconolactobionicum lub Miacalcic. Po sterydoterapii zaobserwowano obniżony poziom badanego mikroelementu,którego zawartość zależała od czasu trwania doświadczenia i rodzaju stosowanych leków
Zbadano zawartość cynku w zębach siecznych szczurów poddanych uprzednio kortykoidoterapii doświadczalnej. Zwierzętom podawano hydrokortyzon oraz hydrokortyzon łącznie z preparatem wapniowym i witaminami A + D3 lub z kalcytoniną przez okres 4 i 8 tygodni. Stwierdzono obniżenie się poziomu cynku w tkance zębowej już po 4 tygodniach terapii hydrokortyzonem. Oznaczenie zawartości cynku wykonano metodą absorpcyjnej spektrometrii atomowej.
The studies in vitro were carried out on isolated thymic cells of Balb/c mice. The thymocyte cultures were incubated with calf thymus extract (TFX) and diethyldithiocarbamate (DTC) at a concentrations of 0.1-100 μg/ml or zinc ions (as sulphate salt) at a concentration of 1 μg/ml, and next the latter culture was supplemented with hydrocortisone at a concentration of 50 μg/ml/culture. The results of the study show that hydrocortisone supplementation decreases the survival rate of cells by approximately 50% in relation to the control. Preincubation of thymocytes with TFX or DTC perse and in zinc interactions increases the percentage of viable thymocytes, as it results in the induction of differentiation and maturation of the cells under investigation. The preventive action of the two drugs against the thymolythic effect of hydrocortisone depends on TFX and DTC concentrations, the presence of zinc ions and length of incubation. A stronger preventive effect against the cytotoxic impact of hydrocortisone has been observed with TFX than with DTC. The effect of steroid resistance of thymocytes induced by the two thymomimetic drugs is enhanced by zinc ions.
Studies carried out on the alga Chlorella vulgaris (Chlorophyceae) showed that hydrocortisone applied in a concentration range of 10-4 - 10-5 M has a stimulating effect on its growth, i.e. the content of fresh and dry mass, and on the chlorophyll and carotenoid contents. Hydrocortisone was found to have its greatest stimulative effect on the biochemical parameters analysed in a concentration of 5x10-5 M between the 15th and 20th day of the alga culture (with the exception of monoxy-xanthophylls). The strongest stimulation was noted in the content of: chlorophylls (a+b), from 184 % - 200 %, the total carotenoid pool, 170% - 190%, including carotenes stimulated from 193 % to 208 %, xanthophylls with 2 oxygen atoms in he molecule 171 % - 191 %, and richly oxidated xanthophylls 146 % -187 %. Maximum stimulation of the dry mass content was within the range of 138 % -151 % whereas the weakest stimulation was noted in the monoxy-xanthophylls 121 % - 125 % as compared with the control (100 %).The studies showed that hydrocortisone, as a typical representative of animal glucocorticoids, also occurring in some species of vascular plants and probably in thallophytes, when applied in the optimum concentration range 10-4 - 10-6 has a fairly intensive stimulative effect on the growth of C. vulgaris cells and their content of photosynthetic pigments, i.e. chlorophylls (a+b) and carotenoids especially carotenes and xanthophylls moderately rich in oxygen.
W doświadczalnej osteoporozie, po zastosowaniu hydrokortyzonu, w zębach siecznych szczurów oznaczono zawartość sodu po 4 i 8 tyg. trwania eksperymentu. Poziom sodu określono również w grupach zwierząt, którym wraz Z hydrokortyzonem podawano preparat wapniowy z witaminą A i D3 lub kalcytoninę. Wyniki porównano z grupą kontrolną.
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