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  1. 6 Journal of Physiology and Pharmacology

  2. 3 Bromatologia i Chemia Toksykologiczna

  3. 3 Folia Histochemica et Cytobiologica

  4. 2 Acta Biochimica Polonica

  5. 2 Acta Neurobiologiae Experimentalis

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  1. 3 Lehotsky J.

  2. 2 Jakubowski H.

  3. 2 Kovalska M.

  4. 1 Adamczak-Ratajczak A.

  5. 1 Adamkov M.

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  1. 1 2018

  2. 2 2017

  3. 1 2015

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  5. 1 2013

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1

Homocysteine thiolactone affects protein ubiquitination in yeast

100%
Bretes E., Zimny J.
Acta Biochimica Polonica
|
2013
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tom 60
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nr 3
The formation of homocysteine thiolactone (HcyTl) from homocysteine occurs in all examined so far organisms including bacteria, yeast, and humans. Protein N-homocysteinylation at the ε-amino group of lysine is an adverse result of HcyTl accumulation. Since tagging of proteins by ubiquitination before their proteasomal degradation takes place at the same residue, we wondered how N-homocysteinylation may affect the ubiquitination of proteins. We used different yeast strains carrying mutations in genes involved in the homocysteine metabolism. We found positive correlation between the concentration of endogenous HcyTl and the concentration of ubiquitinated proteins. This suggests that N-homocysteinylation of proteins apparently does not preclude but rather promotes their decomposition.
2

Plasma homocysteine level and the course of ischemic stroke

88%
Pniewski J., Chodakowska-Zebrowska M., Wozniak R., Stepien K., Stafiej A.
Acta Neurobiologiae Experimentalis
|
2003
|
tom 63
|
nr 2
3

Homocysteine in atherogenesis

75%
Szostak W. B., Olszewski A. J.
Żywienie Człowieka i Metabolizm
|
1990
|
tom 17
|
nr 4
Omówiono rolę homocysteiny w powstawaniu miażdżycy. Inni autorzy opisali zaawansowaną miażdżycę u pacjentów z homocystynurią. Wykazano także, że eksperymentalną miażdżycę można wywołać poprzez karmienie zwierząt homocysteiną i jej pochodnymi. Pirydoksyna jest istotnym składnikiem odżywczym odpowiedzialnym za przemianę homocysteiny do kwasu taurocholowego. Wykazano, że zbyt niskie spożycie pirydoksyny powoduje homocystynurię u ludzi i miażdżycę u zwierząt. Autorzy wykazali zwiększone stężenie homocysteiny w surowicy osób, które przebyły zawał mięśnia sercowego. Hipercholesterolemii towarzyszy szczególnie wysoki poziom homocysteiny we frakcji LDL. In vitro LDL modyfikowane tiolaktonem homocysteiny wykazują szczególne powinowactwo do makrofagów mysich. Pirydoksyna podana razem z niektórymi innymi witaminami powoduje u osób po zawale mięśnia sercowego znaczny spadek poziomu homocysteiny w surowicy. Autorzy wnioskują, że genetycznie uwarunkowane łagodne zaburzenia w metabolizmie homocysteiny mogą w pewnej części populacji przyczyniać się do rozwoju przedwczesnej miażdżycy w przypadku, kiedy dieta jest bogata w metioninę i niedoborowa w pirydoksynę.
4

From accuracy in protein synthesis to cardiovascular disease: The role of homocysteine

75%
Jakubowski H.
Biotechnologia
|
2002
|
nr 3
5
Content available remote

Homocysteine induces endothelial dysfunction via inhibition of arginine transport

75%
Jin L., Caldwell R. B., Li-Masters T., Caldwell R. W.
Journal of Physiology and Pharmacology
|
2007
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tom 58
|
nr 2
Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. High levels of plasma homocysteine (HCY) increase oxidative stress and reduce endothelial-dependent relaxation. We determined whether hyperhomocysteinemia-induced endothelial dysfunction is mediated through inhibition of cellular transport of L-arginine. In endothelial cells, HCY had a biphasic effect on arginine transport. HCY treatment for 6 hr increased L-arginine uptake by 34%; however, uptake was decreased by 25% after 24 h. HCY caused membrane hyperpolarization during both 6 and 24 h incubation periods, indicating that the negative charge facilitating arginine uptake was maintained. HCY significantly reduced expression of cellular arginine transporter protein (CAT-1) after 24 h treatment; whereas endothelial nitric oxide synthase (eNOS) protein levels and basal eNOS activity were not altered. Nevertheless, nitric oxide (NO) formation was significantly decreased. The antioxidant ascorbic acid prevented the effect of HCY on arginine transport. HCY induced formation of the peroxynitrite biomarker nitrotyrosine, which was blocked by supplemental L-arginine. HCY treatment of aortic rings caused decreased vasorelaxation to acetylcholine, which was prevented by supplemental arginine. In conclusion, HCY decreased NO formation and induced endothelial dysfunction without altering protein level or basal activity of eNOS, but through decreases in function and protein expression of the CAT-1 transporter. Reduced arginine supply may lead to eNOS uncoupling and generation of superoxide, contributing to HCY-induced oxidative stress.
6
Content available remote

Gender-related effect of cold water swimming on the seasonal changes in lipid profile, ApoB/ApoA-I ratio, and homocysteine concentration in cold water swimmers

63%
Checinska-Maciejewska Z., Miller-Kasprzak E., Checinska A., Korek E., Gibas-Dorna M., Adamczak-Ratajczak A., Bogdanski P., Krauss H.
Journal of Physiology and Pharmacology
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2017
|
tom 68
|
nr 6
7
Content available remote

Melatonin decreases homocysteine level in blood of rats

63%
Murawska-Cialowicz E., Januszewska L., Zuwala-Jagiello J., Milczarska J., Zawadzki M., Paprocka-Borowicz M., Wierzbicka-Damska I.
Journal of Physiology and Pharmacology
|
2008
|
tom 59
|
nr 4
717-729
Elevated plasma homocysteine level promotes atherosclerosis in blood vessels due to, among others, generation of reactive oxygen species and reduction of nitric oxide bioavailability. The aim of this study was to investigate whether melatonin administration reduces plasma homocysteine level in rats consuming increased doses of methionine in the diet. The trial lasted for two months. The rats were divided into a few groups - 2 groups consisted of animals fed a standard diet, 2 groups consisted of animals fed a diet rich in methionine for one and two months, a group which had methionine removed from the diet in the second month, a group which had methionine removed from the diet and melatonin administered in the second month, a group still fed a diet rich in methonine in the second month and also given melatonin, and a group of animals on a diet rich in methionine for two months and given melatonin at the same time. Hcy, lipid peroxidation markers (MDA+4HNE) and nitric oxide metabolite (NO2-/NO3-) concentrations were determined in the plasma of all the rats. As a result of the tests it was found that plasma Hcy concentration increases in the first month of a methionine-rich diet but then decreases in the second month. MDA+4HNE changes are similar. Melatonin significantly intensifies the effects. The changes of NO2-/NO3- concentrations were noticed especially in the groups receiving melatonin. Elimination of methionine from the feed does not change the value of NO2-/NO3-. NO production increases only after administration of melatonin. On the basis of received results it might be stated that melatonin administration together with a methionine-rich diet significantly decreases Hcy concentration, the level of oxidative stress and increases NO production. It might have some practical implications, especially when the level of endogenous melatonin decreases e.g. in elderly people or people with hyperhomocysteinemia.
8

TGF-beta1 immunohistochemistry and promoter methylation in chronic renal failure rats treated with uremic clearance granules

63%
Miao X.-H., Wang C.-G., Hu B.-Q., Li A., Chen C.-B., Song W.-Q.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 2
284-291
9
Content available remote

Hyperhomocysteinemia as a risk factor for the neuronal system disorders

63%
Petras M., Tatarkova Z., Kovalska M., Mokra D., Dobrota D., Lehotsky J., Drgova A.
Journal of Physiology and Pharmacology
|
2014
|
tom 65
|
nr 1
10

The role of homocysteine in seminal vesicles remodeling in rat

63%
Ghoul A., Moudilou E., El Hadi Cherifi M., Zerrouk F., Chaouad B., Moulahoum A., Aouichat-Bouguerra S., Othmani K., Exbrayat J.-M., Benazzoug Y.
Folia Histochemica et Cytobiologica
|
2017
|
tom 55
|
nr 2
11

C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects

63%
Goracy I., Cyrylowski L., Kaczmarczyk M., Fabian A., Koziarska D., Goracy J., Ciechanowicz A.
Journal of Applied Genetics
|
2009
|
tom 50
|
nr 1
63-67
Hyperhomocysteinemia is reported to be an independent risk factor for the development of ischemic stroke. Several studies on genetic variants of methylenetetrahydrofolate reductase (MTHFR, which plays a crucial role in regulation of plasma homocysteine concentration) reported an association between C677T gene polymorphism and stroke in some Asian populations. No study but one detected this association in Caucasians. The purpose of the present case-control study was to find a relationship between MTHFR genotypes and stroke in a Polish population. MTHFR genotypes were determined by PCR in 152 patients with ischemic stroke from northwestern Poland and in 135 consecutive newborns from the same population. The TT genotype and the T allele were significantly more frequent in patients than in the control group (11.8% vs. 4.4%, and 34.5% vs. 21.5%, P < 0.01). When males and females were analyzed separately, the differences were statistically significant in both genders. It is concluded that presence of the T allele is a risk factor for ischemic stroke in Polish subjects.
12
Content available remote

Metabolomic study of altered energy metabolism during global forebrain ischemia and ischemic preconditioning in blood plasma in homocysteine treated rats

63%
Baranovicova E., Kalenska D., Tomascova A., Lehotsky J.
Journal of Physiology and Pharmacology
|
2018
|
tom 69
|
nr 6
13

Therapeutic strategies for Alzheimer's disease based on new molecular mechanisms

63%
Religa D., Winblad B.
Acta Neurobiologiae Experimentalis
|
2003
|
tom 63
|
nr 4
14
Content available remote

Age and hypertension related changes in genotypes of MTHFR 677C is more than T, 1298A is more than C and PON1-108C is more than T SNPs in men with coronary artery disease (CAD)

51%
Strauss E., Gluszek J., Pawlak A. L.
Journal of Physiology and Pharmacology. Supplement
|
2005
|
tom 56
|
nr 2
65-75
The phenotypes of CAD related to arterial hypertension co-occurrence were analysed in 174 male patients and 117 control men for the associations with the polymorphisms of the MTHFR gene (677C>T and 1298A>C) and the PON1 gene (-108C>T) in relation to age at diagnosis (less or equal and more than 50 years). We noted the increased frequency of the three MTHFR genotypes: CC/AC, CT/AA and CC/CC in the CAD group (65.5%) in comparison to the control group (45.3%), corresponding to the 2.3-fold increased risk of CAD for men with these genotypes (95%CI (1.4-3.7); p=0.0005). The higher increase in risk of CAD was noted for the younger men (OR=3.6; 95%CI(1.6-8.3); p=0.002) and lower for the older (OR=1.8; 95%CI(1.0-3.4); p=0.03). In the normotensive men the greater impact on CAD risk had the homozygous genotypes; the 2.3-fold higher risk was associated with MTHFR CC/AC, CC/CC and TT/AA genotypes (95%CI(1.2-4.4); p=0.01). After adjustment for age, the association between CAD and MTHFR was significant only for the younger normotensive men (OR=2.8; 95%CI (1.0-8.0); p=0.04). Additionally, we found that the younger part of the control group was characterized by higher frequency of the low expression PON1 -108T allele and PON1 -108TT genotype (0.54 and 31.9% respectively) in comparison to the older men (0.41 and 17.1% respectively; p=0.03).
15

Serum homocysteine and oxidative stress evaluation during exercise in horse

51%
Fazio F., Casella S., Giannetto C., Caola G., Piccione G.
Polish Journal of Veterinary Sciences
|
2009
|
tom 12
|
nr 2
169-174
The aim of the present work was to evaluate the influence of exercise on serum homocysteine and oxidative stress in Thoroughbreds during official races. For our study, ten Thoroughbred mares, 5 years old and clinically healthy, were used. The horses were trained to take part in an official 2100 meter race. Reactive oxygen species (dROMs), antioxidant barrier (Oxy-adsorbent), thiol antioxidant barrier (SHp) and homocysteine (sHcy) were investigated. Blood samples, collected from each horse at rest, immediately after the race, and 30 and 180 min after the end of the race, were collected by jugular venipuncture using vacutainer tubes with no additive for the assessment of dROMs, Oxy-adsorbent and SHp by means of a UV spectrophotometer, while serum total Hey values were determined by high performance liquid chromatography with fluorimetric detection and isocratic elution. Statistical analysis, one way repeated measures analysis of variance (ANOVA), followed by Bonferroni's test, showed statistical differences (P<0.05 was considered statistically significant) for all parameters studied. Moreover, a coefficient of linear correlation (r) was computed for values of dROMs and sHcy for all sampling times but a significant linear regression (r = 0.94) was found only after the race. The variations of sHcy, dROMs, Oxy-adsorbent and SHp during the experimental period considered suggest the important role of oxidative status in the athletic horse. The systematic analysis of oxidative stress and its influence on homocysteine levels contribute to the clinical evaluation and assessment of the athletic performance of the horse.
16
Content available remote

The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease

51%
Jakubowski H.
Journal of Physiology and Pharmacology. Supplement
|
2008
|
tom 59
|
nr 9
155-167
17
Content available remote

Combination of hyperhomocysteinemia and ischemic tolerance in experimental model of global ischemia in rats

51%
Kovalska M., Kovalska L., Tothova B., Mahmood S., Adamkov M., Lehotsky J.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 6
18

JAK2 mutation status, hemostatic risk factors and thrombophilic factors in essential thrombocythemia (ET) patients

51%
Sokolowska B., Nowaczynska A., Bykowska K., Chocholska S., Wejksza K., Walter-Croneck A., Gromek T., Kowalska A. M., Kandefer-Szerszen M., Dmoszynska A.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 2
19

Influence of combined botanical extract preparation on blood lipids, glucose metabolism, leptin and homocysteine. Results from double-blind randomized clinical trial

51%
Pilaczynska-Szczesniak L., Rzymski P., Pischel I.
Herba Polonica
|
2007
|
tom 53
|
nr 4
Obesity is associated with possible complications like hyperlipidemia, hypertension, coronary heart disease and diabetes. The aim of this study was to evaluate the effect of composite herbal extracts on blood lipids, glucose metabolism, leptin and homocystein. randomised, double-blind, placebo-controlled clinical trial on 51 overweight, healthy subjects. Preparation of nutrifin® support in a form of tablets, which is a botanical water extract composed of green tea extract, bean peels and asparagus was used. changes in lipoprotein, glucose, insulin, leptin and homocysteine failed to produce statistically significant difference. Alteration of lipid profile including: changes of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were: –9.4%, –18.7%, +11.8%, –13.4% for nutrifin® support group and –8.0%, –12.2%, +1.4% and 14.8% for placebo group, respectively. Differences between groups were not significant. The change in total cholesterol and LDL cholesterol strongly correlated with start values of total cholesterol and LDL cholesterol. The correlation coefficients were –0.92 and –0.91 (p<0.001) in active extract group, respectively. Most of researched changes in blood parameters in both groups were not significant, but the reduction in total cholesterol and LDL cholesterol was strongly correlated with lipids levels at the start of the study.
20

The comparison of pro- and antioxidant processes and activities of lipid metabolism in the rabbits on casein and soybean protein enriched diets

51%
Kopieczna-Grzebieniak E., Drozdz M., Piskorska D., Grabowska-Bochenek R., Wesolowski W., Toborek M.
Current Topics in Biophysics
|
1994
|
tom 18
|
nr 2
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