Wyniki wyszukiwania

1

Central histamine-induced reversal of critical haemorrhagic hypotension in rats - haemodynamic studies

100%

Jochem J.

Journal of Physiology and Pharmacology

|

2002

|

tom 53

|

nr 1

Volume-controlled irreversible haemorrhagic shock in rats produced by blood withdrawal until stabilisation of critical mean arterial pressure (MAP)20-25 mmHg is associated with an extreme decrease in cardiac index (CI)and an increase in total peripheral resistance index (TPRI),with reductions in renal (RBF),hindquarters (HBF)and mesenteric blood flow (MBF),and leads to the death of all control animals within 30 min.Histamine (100 nmol)injected intracerebroventricularly (i.c.v.)in the early phase of critical hypotension produces a prompt and long-lasting increase in MAP and heart rate,with a 100%survival for 2 h after treatment.The effects are associated with the rise in the circulating blood volume and CI,and the decrease in TPRI,with the increase in RBF and HBF,and persistently lowered MBF.Both splenectomy and ligation of the suprahepatic veins inhibit histamine-induced increase in circulating blood volume as well as cardiac and regional haemodynamic effects.It can be concluded that histamine administered icv activates central endogenous compensatory mechanisms,which leads to the reversal of haemorrhagic shock conditions due to the mobilisation of blood from venous reservoirs,the increase in circulating blood volume and its redistribution.Moreover,histamine evokes the rises in CI and perfusion of the renal and skeletal muscle vascular regions.

2

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats

100%

Jochem J.

Journal of Physiology and Pharmacology

|

2000

|

tom 51

|

nr 2

3

Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats

84%

Jochem J., Savci V., Filiz N., Rybus-Kalinowska B., Fogel W. A., Yalcin M.

Journal of Physiology and Pharmacology

|

2010

|

tom 61

|

nr 1

37-43

Cytidine 5’-diphosphocholine (CDP-choline) is an endogenously synthesized mononucleotide which exerts a variety of physiological effects by altering central cholinergic transmission. Administered intracerebroventricularly (i.c.v.) or intravenously, it reverses haemorrhagic hypotension in rats, apparently by the activation of central cholinergic receptors. The study was undertaken to investigate the involvement of the central histaminergic system in CDP-choline-mediated reversal of haemorrhagic hypotension. Experiments were carried out in male ketamine/xylazine-anaesthetised Wistar rats subjected to haemorrhagic hypotension of 20-26 mmHg. CDP-choline (2 µmol; i.c.v.) administered at 5 min of critical hypotension produced a long-lasting pressor effect with increases in mean arterial pressure (MAP), heart rate (HR), and renal, hindquarters and mesenteric blood flows, resulting in a 100% survival at 2 h. The action was accompanied by approximately a 26% increase in extracellular histamine concentration at the posterior hypothalamus, as measured by microdialysis. Cardiovascular effects mediated by CDP-choline were almost completely blocked by pretreatment with H1 receptor antagonist chlorpheniramine (50 nmol; i.c.v.), but not with H2 receptor blocker ranitidine (25 nmol; icv) or H3/H4 receptor antagonist thioperamide (50 nmol; i.c.v.). In conclusion, the present results show that the central histaminergic system, through the activation of H1 histaminergic receptors, is involved in CDP-choline-induced resuscitating effect in haemorrhage-shocked rats.

4

Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats

84%

Jochem J., Altinbas B., Yalcin M., Ottani A., Giuliani D., Savci V., Kasperska-Zajac A., Guarini S.

Journal of Physiology and Pharmacology

|

2016

|

tom 67

|

nr 1

5

Regulation of feeding behaviour, with special reference to histamine

84%

Tuomisto L.

Journal of Physiology and Pharmacology

|

1994

|

tom 45

|

nr 4

6

The central histamine level in rat model of vascular dementia

67%

Stasiak A., Mussur M., Unzeta M., Lazewska D., Kiec-Kononowicz K., Fogel W. A.

Journal of Physiology and Pharmacology

|

2011

|

tom 62

|

nr 5

7

Satiety signalling histaminergic system and brain-gut peptides in regulation of food intake in rats with portocaval anastomosis

67%

Fogel W. A., Stasiak A., Lewinski A., Maksymowicz M., Jochem J.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 2

Brain histamine plays a regulatory role in feeding behaviour, acting as an inhibitory modulator. Portocaval anastomosis (PCA) is associated with cerebral aminergic systems alterations, including high histamine accumulation and release from neurons. Despite that, the rats with PCA eat significantly more, their body mass being lower than sham-operated animals. To disclose underlying regulatory mechanisms, food intake was measured before and after treatment with antagonists of histamine H1 and H2, orexin type 1 (OX1) and cannabinoid type 1 (CB1) receptors in adult male Lewis rats 6 months following the end-to-side PCA or sham operation. Hypothalamic concentrations of orexin A and histamine as well as serum concentrations of leptin, insulin and cholecystokinin (CCK) were analysed. PCA rats with body mass lower by 30%, have consumed more feed and water 150% and 200%, respectively. The modifying effects of pyrilamine, ranitidine, SB 334867 and rimonabant were less pronounced in PCA compared with sham-operated rats. Hypothalamic orexin A and histamine concentrations were higher in PCA rats than in the control group with intact portocaval system. In PCA rats, serum concentrations of CCK were higher, leptin concentrations lower, while there were no differences between the groups in insulin levels. In conclusion, the adaptive mechanisms efficiently render PCA rats less sensitive to peripheral and central anorexigenic signals. Orexin A appears to be involved in the counteracting mechanisms preventing further body mass loss in PCA rats.

8

Nitric oxide and prostaglandin systems in the stimulation of hypothalamic-pituitary-adrenal axis by neurotransmitters and neurohormones

67%

Bugajski J., Gadek-Michalska A., Bugajski A. J.

Journal of Physiology and Pharmacology

|

2004

|

tom 55

|

nr 4

The review presents our results on the regulatory role of prostaglandins (PG) and nitric oxide (NO) in the activation of hypothalamic-pituitary-adrenal (HPA) axis by cholinergic, adrenergic and histaminergic systems and by neurohormones: corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) under basal conditions. The synthesis of endogenous PG or NO was inhibited by non-selective and selective cyclooxygenase (COX) antagonists and nitric oxide synthase (NOS) blockers given 15 min before the respective receptor agonist and HPA axis activity was assessed 1 h later by measuring plasma ACTH and serum corticosterone levels. The muscarinic agent - carbachol-induced HPA response was considerably supressed by piroxicam, a predominantly constitutive cyclooxygenase (COX-1) inhibitor and significantly diminished by indomethacin, a non-selective COX blocker, but was unaffected by compound NS-398, an inducible cyclooxygenase (COX-2) antagonist. A non-selective NOS antagonist L-NAME and neuronal NOS blocker L-NNA significantly intensified the carbachol-induced corticosterone secretion. The nicotine-induced increase in ACTH and corticosterone response was significantly supressed by piroxicam, and diminished by indomethacin, but was significantly augmented by L-NAME and L-NNA. The inhibition of PG synthesis by indomethacin totally abolished or reversed the increase of nicotine-induced hormone responses to both NOS blockers. The i.c.v. phenylephrine, an alpha1-adrenergic receptor agonist - evoked HPA response was significantly impaired by piroxicam and compound NS-398 and more potently reduced by L-NAME. The i.c.v. clonidine, an alpha2-adrenergic agonist - elicited HPA response was also considerably decreased by piroxicam, compound NS-398 and L-NAME. By contrast, the stimulatory effect of i.c.v. isoprenaline, a non-selective ß-adrenergic agonist, was not altered by either COX or NOS inhibitors. The i.c.v. histamine- and HTMT, a histamine H1-agonist-induced ACTH and corticosterone response were significantly diminished by piroxicam and indomethacin, respectively. Compound NS-398, did not markedly alter the HPA response to HTMT or amthamine, a histamine H2 receptor agonist. Inhibition of endogenous NO synthesis by a neuronal NOS inhibitor 7-nitroindazole markedly enhanced the histamine-induced hormone secretion, abolished the HTMT-induced response and did not substantially alter the amthamine-evoked ACTH and corticosterone secretion. COX blockers did not significantly affect the CRH-induced HPA response and the inhibition of NO synthesis by L-NNA markedly intensified ACTH response. The vasopressin-stimulated increase in HPA response, was considerably reduced by the inhibition of PG synthesis by both COX antagonists while inhibition of NO synthesis by NOS blockers greatly enhanced this response. The involvement of PG and NO in the neurohormonal regulation of HPA activity depends mainly on greatly complex and tightly regulated mechanisms at the level of second messengers IP3 and adenylyl cyclase systems.

Ograniczanie wyników

Central histamine-induced reversal of critical haemorrhagic hypotension in rats - haemodynamic studies

Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats

Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats

Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats

Regulation of feeding behaviour, with special reference to histamine

The central histamine level in rat model of vascular dementia

Satiety signalling histaminergic system and brain-gut peptides in regulation of food intake in rats with portocaval anastomosis

Nitric oxide and prostaglandin systems in the stimulation of hypothalamic-pituitary-adrenal axis by neurotransmitters and neurohormones